A Study of the Times and Labors of William
Harvey[9]
History in general is but a record of the
succession of great events or epochs which
have moulded the world's affairs. That
which is of the greatest import in the
life of the individual may count for little in the lives
of his contemporaries, and yet it must be said that in
the events of to-day there has occurred a great epoch
in the life of each of you, presumably the most important
as yet in your personal records. This day is
then in your personal histories one of the greatest
importance. It is desirable, therefore, that your lives
be so moulded and influenced by it that you may long
hence look back to it and recall its significance.
I do not know what advice I can give you which
will be more fruitful of results, than that among
your studies you include that of the lives of the great
men who have moulded destiny and made the world's
history. Their lives were modified by little things,
as have been and will be yours, and yet out of small
matters grew for them and for us some of the most
far reaching effects. Select the really great men
of whom you best happen to know and analyze their
characters that you may appreciate how they have
become great; while if they have, as all great men
have, traits of smallness, study even wherein they are
small, and how such faults may be avoided.
History runs as does a fairly steady stream, save
that every now and then some event abruptly diverts
its course or influences its current. It has been so,
for instance, with the history of medicine. For the
first sixteen hundred years of the Christian era men
engaged in the crude practices of our profession, utterly
ignorant of the course of the blood, as well as
of its purposes. Then appeared upon the scene a
man who did his own thinking, who was willing to
free himself from the shackles of the past, to observe
nature and to reason therefrom. In this way came
suddenly upon the world, as it were, an appreciation
of the Circulation of the Blood, than which perhaps
no event in medical history has been of greater importance
or reflected more credit upon its demonstrator.
It is my purpose, then, to-day to try to tell you,
in a semipopular way, how William Harvey came to
make this great discovery, as well as to give you
some idea of the difficulties under which he worked,
and of the men and influences that surrounded him,
believing that rather than spend a half hour in humorous
platitudes which may provoke a smile, but
which are quickly forgotten, it is much better to try
to implant something which may linger a while in
your memories, and sufficiently impress you with the
value of observation and inductive reasoning, since
if you become thus fully impressed you will be spared
in the future many sad errors of speech and even of
thought.
Before telling the story of Harvey's life and work
let us study for a few moments the general condition
of affairs in Europe, in order that we may better
understand the men whose influence surrounded him,
as well as the spirit of the times and men's habits
of thought.
Among the monarchs reigning in various parts of
Europe during Harvey's time there were, for instance,
in that part of the Empire of the West which
was called Germany, Rudolph II, Matthias and Ferdinand.
In Sweden reigned King Sigismund, Charles
IX, the great monarch Gustavus Adolphus, and
Queen Christine. In Prussia the throne had been occupied
by Joachim, George William and Frederick
William, as electors, this being before the days of the
Prussian kings. In Russia the Czars Boris Godunow,
Michael Theodore and Alexis had occupied the
throne.
France had but recently passed through the inhuman
butchery of the massacre of St. Bartholomew
and its accompanying persecution of the Huguenots,
under Charles IX, who expressed the hope that not a
single Huguenot would be left alive to reproach him
with the deed, but who died himself soon after the
massacre, which is said to have caused him bitter remorse.
Charles had been succeeded by his brother
Henry III, a weak, fickle and vicious monarch, whose
weakness caused him to be embroiled in civil strife,
which was only concluded by his own assassination
at the hands of a Dominican friar. Then came Henry
IV, he of Navarre, afterwards surnamed The
Great, who fought the famous battle of Ivry in 1590,
and who reigned for twenty-one years, the greatest
and most popular sovereign who ever occupied the
throne of France. Notwithstanding his noble qualities
he did not succeed in preserving his court from
many of the contaminations of the age, and in his
reign it is said that no less than 4,000 French gentlemen
were killed in duels, chiefly arising out of quarrels
about women. He was succeeded by Louis XIII,
who was still on the throne when Harvey died.
In Harvey's own country James I was occupying
the throne when Harvey appeared upon the scene.
He was that royal pedant whom the Duke of Sully
pronounced "the wisest fool in Europe." After his
death, and when Charles I ascended the throne during
his twenty-fifth year, in 1625, Harvey was preparing
to publish his great work. It was this Charles
I who retained as a favorite the worthless scoundrel
Buckingham, whose misconduct in Spain prevented
the proposed marriage of the king with the Spanish
Infanta and brought about the Civil War. It was
because of the cost of this war, and of the king's
disputes with Parliament regarding the matter, that
England was rent between the conflicts of the Cavaliers
and the Roundheads, two of the consequences
of this intestine strife being the execution of the Earl
of Strafford and of Archbishop Laud. The troubles
thus engendered finally cost the life of the king himself,
who was beheaded in 1649. Harvey even lived
to see the first half of the short tenure of office of
Cromwell as the Great Protector, and was perhaps
fortunate in dying before began the reign of that
odious profligate Charles II.
It is worth while to enquire for a moment what
was doing on this side of the ocean at this period
which we have now under consideration. In 1607
Virginia was settled by the English, in 1614 New
York, by the Dutch, in 1620 Massachusetts and,
three years later, New Hampshire, by the English
Puritans; in 1624 New Jersey, by the Dutch, in 1627
Delaware by Swedes and Finns, in 1630 Maine, by
the English, in 1634 Maryland, by Irish Catholics,
in 1635 Connecticut, by English Puritans. Thus it
will be seen that the active period of Harvey's life
was synchronous with the beginnings of our colonial
activities. Very little knowledge of what was going
on in the then world of science was brought to this
country at this period of its existence, however, and
it was many years before in these colonies there were
any exhibitions of scientific interest save in extremely
scattered and sporadic cases.
Among Harvey's literary associates were a number
of celebrated English poets, for example,—Marlowe
(1593), Spenser (1598), Beaumont (1615), Shakespeare
(1615), Herbert (1635), Ben Jonson
(1637), Massinger (1639). Lord Bacon died a
year or two after the appearance of Harvey's book,
while Baron Napier, the inventor of logarithms, had
passed away. His contemporaries in Italy, where he
had studied, included Tasso (1595) and Galileo
(1645). Rubens had died in 1640, Michael Angelo
in 1564 and Titian in 1576. In France, Calvin, the
practical murderer of Servetus, had passed away in
1564, Beza died in 1605, Descartes in 1650, Pascal
in 1662 and Gassendi in 1655. Portugal had produced
but one great figure in the 16th century, namely
Camoens, who died in 1579. In Spain, Loyola, the
ascetic and fanatic founder of the Jesuits, had joined
the great majority in 1556; but Cervantes did not
die until 1616, Lope de Vega in 1635, Velasquez in
1660 and Calderon in 1667.
In Germany some great figures had but recently
disappeared. Paracelsus died in 1541, Copernicus
in 1543, Luther in 1546, Hans Holbein in 1554, and
Melancthon in 1560. Mercator, who introduced a
new method of cartography, died in 1594, Tycho
Brahe in 1601, Keppler in 1631, Van Dyck in 1641,
Grotius, the great scholar, in 1645, Rembrandt in
1668 and Spinoza in 1677.
In philosophy, scepticism was the prevailing doctrine
in the time of Harvey. It had been founded a
hundred years previously by Montaigne, and continued
by Charron, the chaplain of Queen Margaret of
Navarre, who died in 1603, and who declared all
religion to be opposed to human reason;—a remarkable
attitude for a chaplain to assume. Opposed to
the scepticism of Harvey's day was the mystic, Cabalistic
or supernatural philosophy especially represented
by Böhme, a peasant shoemaker, uneducated
and yet wonderfully gifted. He had been the philosophical
colleague of that great Meistersinger, Hans
Sachs. Later philosophers and thinkers, yet belonging
to Harvey's time, were Pascal, the great Jansenist,
who discovered the variations of atmospheric pressure
at different levels, and Malebranche, who figures
prominently in the history of philosophy.
Descartes, who died in 1650, held the pineal gland
to be the seat of the soul. He was the discoverer of
the laws of refraction of light and furnished the explanation
for the rainbow. He attained greatest eminence
in mathematics, physics and philosophy, and
was one of the inventors of modern algebra. One
of his greatest opponents was that noble Jew, Spinoza,
whose colleagues had expelled him from the
Sanhedrim to the sound of the trombone.
The Italian Dominican Campanella, who died in
1639, considered the foundation of knowledge to be
supernatural revelation and its perception by the
senses. In spite of these views he came before The
Inquisition on a charge of heresy and of cooperation
with the Turks, was tortured by the rack, and imprisoned
for thirty years.
The mystic or Cabalistic notions of Harvey's day
have just been mentioned. Under them we may
recognize many degenerate products and amalgamations
of the real doctrines of Paracelsus. The doctrines
of the Rosicrucians, as well as of Zoroaster and
the Cabala, were revived and made to do strange
work. There was, for instance, that Sir Kenelm
Digby, who died in 1605, a King's chamberlain, who
posed among the English as a so-called Rosicrucian.
It was he who suggested the famous "sympathetic
powder," which was to be applied to the weapon by
which a wound had been inflicted, after which the
weapon was anointed and dressed two or three times
a day, while the wound itself was carefully bound up
with dressings and left alone for a week. This was
perhaps much the better course, but it will show what
strange notions prevailed in those days.
What it meant to run counter to ecclesiastical policy
and theological dogma appears not only in such tragedies
as terminated the lives of Bruno and many other
martyrs to science, but in such facts as these; for
instance, when in 1624, just when Harvey was preparing
to publish his work, some young chemists in
Paris, seeing the benefit of the experimental method,
broke away from Aristotle and the canons of theological
reasoning, the faculty of theology appealed to
the Parliament of Paris, which latter prohibited all
such researches, under the severest penalties.
This was the time too when such exhibitions as
the following were altogether too frequent;—One
Quaresimo, of Lodi, came out with a ponderous work
entitled "A Historical, Theological and Moral Explanation
of the Holy Land," in which he devoted
great space to the question of The Dead Sea and the
salt pillar supposed to represent Lot's wife, dividing
a long chapter upon the subject into three parts, dealing
with the method and the locality of this transformation
and the question of the existence at that time
of her saline remains. Thus, with his peculiar powers
of reasoning, he was able to decide the exact point
where the saline change took place, and finally showed
that the statue was still in existence.
Lord Bacon was also an older contemporary of
Harvey, having been born in 1561 and dying in 1626,
shortly after the appearance of Harvey's great work.
His services to analytic science need no description
here, but it is worth while to remember that Harvey,
like many others, must have come under his influence
and have profited by his teachings in logic and analysis.
At about the time when Harvey made known his
discovery Bacon was publishing his views of the laws
of transmission and reflection of sound. Great man
as he was, with a keen foresight into the value of the
recent inventions of the compass, gun-powder and
printing, he nevertheless was himself so narrow, in
some respects, that he placed but little value upon the
discovery of Copernicus. He, however, paved the
way for one in some respects still greater, namely
Isaac Newton, who, however, had scarcely attained
man's stature when Harvey died.
How much we owe to the two great Bacons of
history one cannot indicate in this short résumé. Roger
Bacon (1214-1292) seems to have been the first
great thinker along truly scientific lines. He was
more than a mere chemist while, as White says, more
than three centuries before Francis Bacon advocated
the experimental method Roger Bacon had practised
it, and in many directions. He did more than anyone
else in the middle ages to direct thought into
fruitful paths, and only now are we finding out how
nearly he reached some of the principal doctrines of
modern philosophy and chemistry. Most important
of all, his methods were even greater than his results,
and this at a time when "theological subtilizing" was
the only passport to reputation for scholarship.
It was Avicenna, the Arabian, who perhaps first
announced substantially the modern theory of geology,
accounting for changes in the earth's surface
by suggesting a stone-making force, but the presence
of fossils in the rocks had been always a thorn in the
sides of the theologians. It was Leonardo da Vinci,
that versatile genius in science and art, who, previous
to Harvey's generation, suggested true notions as to
the origin of fossils, while, in Harvey's time, Bernard
Palissy, another artist, vehemently contended
for their correctness. Still, even at Harvey's death,
neither geology nor paleontology had come anywhere
near scientific accuracy.
The Academia dei Lyncei, so-called from its seal,
which bore the image of a fox, was founded in Rome
in 1603. In France The Academy of Science was not
founded until 1665, in Germany The Society of Naturalists
and Physicians in 1652, and the British Royal
Society in 1665.
In matters of general interest it may be worth while
to say that in architecture the general style of The
Renaissance was changed for the more substantial
Barocco, while the more formal and limited style of
church music had given away to musical drama, i. e.,
opera, albeit in very crude form. The first newspaper
had appeared at Antwerp in 1605, the first
German paper being published in Frankfort in 1615,
and The London Weekly News making its first appearance
in 1620. Tobacco, which had been brought
over by Raleigh in 1560, had come into quite general
use, while coffee, tea and chocolate had gained in
public esteem. When coffee was first introduced in
England it sold for about $28 a pound. The first
coffee house appears to have been established in Constantinople,
in the middle of the 16th century, while
the first coffee house in London was not opened until
a century later.
The barbers still retained their ascendency, and
the bath keepers had scarcely lost their position next
to the barbers. It was not until Harvey had reached
a ripe age that the barbers were required in Germany
to pass an examination, in which they had to prove
not only their knowledge but the legitimacy of their
birth, and the fact that they had studied for three
years and had worked for three years more as apprentices.
Anatomy was studied quite generally, sometimes
upon human bodies. A dissecting room had been
established in Dresden in 1617, in which stuffed
bears, at that time a great rarity, were preserved with
other curiosities. In 1623 Rolfink, at Jena, arranged
for public dissection upon the bodies of all executed
malefactors, delegates being present thereat from
various other institutions. It is worth while to mention
that in Frankfort, for instance, during the expiration
of 65 years, but seven dissections were made,
and that these were always accompanied by a celebration
which lasted several days. Vienna did not possess
a skeleton in 1668, and Strassburg did not have
one until 1671. Yet it is of interest to remember
that the anatomical plates, like those often published
to-day, which are meant to be lifted off in layers, existed
even at this period. On the other hand, botanical
gardens and chemical laboratories existed in
several of the universities,—in Strassburg, for instance,
in 1619,—in Oxford in 1622.
Fabricius Hildanus, the father of German surgery,
or, as he has been sometimes called, the Ambroise
Paré, of Germany, was also a contemporary of Harvey's.
His real name was Fabry and he was born in
Hilden, but he latinized his name into that form usually
adopted to-day.
Scultetus was another famous surgeon of the same
period.
William Gilbert, 1540-1603, had been the talented
physician of Queen Elizabeth, and was among the
first to study the experimental method. With the
appearance of his book upon the magnet, in 1600,
began the science of electricity and magnetism. He
was the first to teach the fact that the earth itself was
a great magnet and he distinguished between magnetic
and electric reactions. Later the great
Dutch anatomist, Ruysch, afforded corroboration
of Harvey's views by another method, when
he invented and practised those beautiful minute injections
of the vascular system which made him so
famous, and built up that great collection of
specimens which Peter the Great bought for Russia
at an expense of about $75,000.
Contemporary with Harvey also was Swammerdam,
one of the most versatile men of his time, famous
as naturalist, savant, physiologist, linguist and
poet. It was during the fifteenth century that astronomy
began to assume an importance and degree
of accuracy never hitherto known. This was due
very largely to the independence of thought and the
researches of Copernicus, who was born in Cremona
in 1477, and who studied medicine in Krakau and astronomy
in Vienna. He lived to the age of 70 and
was the real father of the heliocentric theory, now
known as the Copernician system, which he substituted
for the previous Ptolemaic theory, thus reversing
the ancient idea that the sun circled about the
earth. Copernicus demonstrated the phases of the
moon, but his opponents claimed that if this doctrine
were true Venus would exhibit the same phenomena;
to which he replied that it was true, though he knew
not what to say to these objections, but that God was
good and would in time furnish answer to them. It
was Galileo's crude telescope which, in Harvey's
younger day, in 1611, furnished this answer and revealed
the phases of Venus. To illustrate how the
views of Copernicus were received we might add here
that Martin Luther paid his compliments to him by
declaring that Copernicus was a fool who wished to
stand astronomy upon its head.
Copernicus was succeeded by Galileo, who was
born in 1554 in Pisa, and died 1642. He may be
called the creator of dynamic astronomy and mechanics,
as well as one of the most brilliant exponents of
experimental and inductive reasoning. He was of noble
birth and was, in fact, the torch bearer of physics
at the period of The Renaissance. He gave up speculation
and substituted for it the habit of observation,
reaping a large harvest of surprising facts, any one
of which might have immortalized him. He not only
established the movements of the earth on its own
axis as well as around the sun, which Copernicus had
shown, but he discovered the weight of the atmosphere
and first calculated the law of gravity. He and
his successors were governed always by that aphorism
which is to-day as true as ever: "Experience is
deceptive and judgment difficult."
In 1615 when he was before The Inquisition, at
Rome, and when its theologians had examined statements
extracted from his letters, they solemnly rendered
their decision in these words: "The first proposition
that the sun is the centre and does not revolve
about the earth is foolish, absurd, false in theology
and heretical, because expressly contrary to The Holy
Scripture. The second proposition that the earth is
not the centre, but revolves about the sun, is absurd,
false in philosophy and, from a theological point of
view, at least, opposed to the true faith." This for
a pronunciamento from the infallible Church!
Galileo and Bruno have by some writers both been
made to stand in an unpleasant light because of their
recantation or shifting position before The Inquisition.
Bruno was the greatest philosopher and sceptic
of the latter part of the 16th century, and had outlined,
withal somewhat vaguely, that which is now
known as the nebular hypothesis. He was murdered
by The Inquisition in 1600, and the views which he
enunciated seem to have been buried with him, not
to reappear until long after his sad fate had been consummated.
He had, for instance, contended for the
truths of the Copernican doctrine, but it was not until
ten years after his martyrdom that Galileo proved
it with his telescope. That both these great men
yielded in some respects to the influences of The Inquisition
and renounced some of their scientific "heresies"
is largely to be excused by the fact that they were
both old, broken in health from the sufferings which
they had endured, as well as from their disappointments,
and that they had been, under these circumstances,
handed over to that Inquisition which knew
no mercy. Galileo could well remember the auto
da fê in the Piazza dei Fiore, in Rome, the scene of
Bruno's martyrdom, as well as the tragic end of many
another who had dared to have the courage of his
convictions. Let us, then, not judge him harshly, but
be grateful even that the enormous power of The Inquisition
did not and could not suppress the truth.
Galileo's discovery of the satellites of Jupiter, the
rings of Saturn, his experiments with the pendulum,
his construction of the telescope, as well as of the
thermometer, and many other deeds, have stamped
him as one of the great figures in the history of progress
and science. It is most interesting to note that
this contemporary of Harvey's, like himself, was given
to inductions obtained from experimental studies.
Another great astronomical light of Harvey's time
was Keppler, who was driven from one place to
another by religious fanaticism, until he ended his life
in 1630. It was he who formulated the great principle
which underlies the motions of the planets, and
who gave to the world his so-called "laws," which so
materially advanced the science of astronomy. It
was he who really discovered that comet which was
later given Hailey's name, whose periodic return he
first foretold.
Such was the spirit of the times in which Harvey
lived, and such the influences which surrounded his
teachers before him and himself in turn. It makes
a long preface to a consideration of what Harvey
himself accomplished, but it is not without its interest
because men and their deeds must be judged largely
by their environment. Now, to speak more particularly
of Harvey himself, and what was known of the
circulation when he undertook his investigations.
The liver had been considered, from time immemorial,
as the principal factor in the production and
movement of the blood. The ancients supposed that
here the veins took their origin and that through
them the blood flowed to all parts of the body, returning
to its source by an undulating movement or
series of alternate waves. The arteries had been supposed
to contain only vital spirits, whose great reservoir
was the heart, although Erasistratus had admitted
that in certain cases blood might escape into the
arterial channels. Later Galen showed that the arteries
always contained blood, and he knew that blood
was poured into the right side of the heart by the
great veins, but believed that only a little of it passed
from the right ventricle into the lungs, the greater
part of it passing through hypothetical pores in the
septum and thus into the left ventricle. This opinion,
like Galen's in other respects, remained unchanged
until the middle of the 16th century. It was also
known that valves existed within the veins, and that
if an artery were tied on a living animal blood would
cease to flow and pulsation be checked below the ligature,
while if a vein were tied it shrunk above the
ligature and became distended below.
Three men before Harvey's time came very near
to discovering the secret that made him famous; in
fact, they made such advances on what was already
known that history should accord them a distinguished
place. One was Columbus, who was born
at Cremona in 1490, and died in 1559. He was first
a pupil and prosector and then a friend of Vesalius,
the great anatomist. Later he succeeded him at The
University of Padua and unfortunately, after gaining
his position, ungratefully turned upon his old teacher.
He was, however, for his day a good anatomist
and especially a good osteologist. It was he who
first demonstrated experimentally that blood passes
through the lungs into the pulmonary veins and that
the latter connect with the left ventricle. He thus
practically established the fact of the lesser circulation.
He suffered, however, as did Servetus, from
the prevailing notion that spirits and blood were
mixed together. From Padua Columbus went to
Pisa, and then to Rome. He wrote with elegance
and correctness of style and even described the vessels
which penetrate the bone cells, the ossicles of the ear,
the minute anatomy of the teeth, the ventricles of the
larynx, as well as those valves which prevent the return
of blood from the lungs to the heart. In fact,
he narrowly missed the significance of the actual facts
of the case, simply failing in his final analysis and assembling
of those facts which he had already demonstrated.
Cesalpinus, who lived a little later, came still nearer
the mark, having accepted the teachings of Columbus
regarding the course of the blood through the
lungs. He added that the ultimate arterial branches
connect with those of the veins, and he taught that
blood and vital spirits, from which the ancients could
never separate themselves, passed from the arteries
into the veins during sleep, as was demonstrated by
the swelling of the veins and the diminution of the
pulse at that time.
A little later came Michael Servetus, who figures
principally in history as a theologian and a victim of
theologians, since he perished a martyr to Calvin's
jealousy. He was, in effect, a wisely and widely educated
man who did a great deal for science, one of
the offences attributed to him being an edition of
Ptolemy's geography, in which Judea was described
as a barren and inhospitable land instead of one
"flowing with milk and honey." This simple statement
of a geographical fact was made a tremendous
weapon of offence by Calvin, who replied that even if
Servetus had only quoted from Ptolemy and, although
there were ample geographical proofs, it nevertheless
"unnecessarily inculpated Moses and grievously outraged
The Holy Ghost." Servetus dared to deny the
passage of the blood through the septum of the heart,
and contended that that which comes into the right
side was distributed to the lung and returned to the
left ventricle. He published his views, however, in
a religious treatise on Errors concerning The Trinity,
a most unfortunate place in which to inject such an
important fact, since it gave his enemies a still greater
opportunity to vent and ventilate their spleen. Had
he been able to leave out that notion of vital spirits,
which prevailed with all his predecessors, he might
actually have made the great discovery left for Harvey
to enunciate. I have not been able to refer to
original documents in this matter, but it is claimed
by some that his description of the circulation was
contained in another religious work concerning the
Restitution of Christianity, which was printed in
Nuremberg in 1790.
Such was the actual state of knowledge concerning
the movements of the blood and the functions of
the heart when Harvey published his great work. It
behooves us now to proceed with a short account of
Harvey's own life and researches.
William Harvey was born at Folkestone on the first
of April, 1578. He was the eldest son of a prosperous
merchant who raised a large family and who occupied
the highest positions of honor in his own town.
The son William was born to his second wife, by
whom he had seven sons and two daughters. All of
these children were helped to remunerative or honorable
positions. They became merchants or politicians
or secured prominence in some way, but William was
the only one to study medicine. He was sent to the
King's school at Canterbury, in 1588, and he was
admitted at Caius, in Cambridge, in 1593, where he
graduated in arts in 1597. The following year he
went to Padua, which then had one of the greatest
medical schools of the time, and he obtained his
medical diploma in 1602, when twenty-four years of
age. Returning to England he received a doctor's degree
at Cambridge, and shortly afterward married a
daughter of a London physician and entered upon the
practice of medicine in London.
In the great city his practice as a physician seems
to have been from the outset successful, and his knowledge
and ability procured him various valuable appointments.
He was made a Fellow of The College
of Physicians in 1607. This Royal College of Physicians
was given a grant of incorporation by Henry
VIII in 1518, at the intercession of Chambers, Linacre
and Ferdinand Victoria, the King's Physicians,
it being under the patronage of Cardinal Wolsey.
The first meetings were held at Linacre's house which
he bequeathed to the corporation at his death. Until
this College was founded practitioners of medicine
were licensed to practise by the Bishop of London
or by the Dean of St. Paul's.
A few years later Harvey was appointed Physician-Extraordinary
to King James I, and later yet, after
the publication of his great treatise and its dedication
to the King, he was made Physician-in-Ordinary to
Charles I, whom he attended during the Civil Wars.
It must have been about 1615 when Harvey first
began expounding his views on the circulation of the
blood, during lectures which were delivered at The
College of Physicians, but it was not until thirteen
years later, i. e., in 1628, that his great work DE
MOTU CORDIS was published in Latin, as was customary
among scholars, and at Frankfort-on-the-Main,
since that was then the great center of the book
publishing trade.
The treatise was dedicated to King Charles I, in a
manner which to us would seem servile, and yet which
was according to a custom followed by nearly all of
the scholars of the day, who desired to attract not
only the attention of royalty, but, in most instances,
their benevolent assistance. It is worth while to quote
at this point the first sentence or two of his dedication:
"To the
Most Serene and Invincible
CHARLES,
of Great Britain, France and Ireland,
KING: DEFENDER of the FAITH,
Most Serene King,
"The heart of animals is the basis of their life,
the principle of the whole, the Sun of their Microcosm,
that upon which all movement depends, from
which all strength proceeds. The King in like manner
is the basis of his Kingdom, the Sun of his World,
the heart of the Commonwealth, whence all power
derives, all grace appears. What I have here written
of the movements of the heart I am the more
emboldened to present to your Majesty, according to
the Custom of the present age, because nearly all
things human are done after human examples and
many things in the King are after the pattern of the
heart."
The dedication was followed by a Proemium which
one may hardly read to-day without emotion. In it
he sets forth the mystery that has surrounded the subject
of the motion and function of the heart, as well
as the attendant difficulties of the subject, speaking
of his own early despair that he would ever be able to
clear up the subject. He even said that at one time
he found the matter so beset with difficulties that he
was inclined to agree with Fracastorius "that the
movements of the heart and their purpose could be
comprehended by God alone." Only later was this
despair dispelled by a suggestion when, as he says:
"I began to think whether there might not be a movement
in a circle" when thus the truth dawned fully
upon him.
We shall have to speak later of the opposition provoked
by the appearance of this work and its almost
general rejection. It is perhaps, however, but just to
those who disputed Harvey's discoveries to recall that
no complete and actual demonstration of the actual
circulation was possible at that time, nor for many
years after, and until the introduction of the microscope,
the common magnifying glass of that day being
the only lens in use. It remained for Malpighi to
demonstrate the blood actually in circulation in the
lung of a frog some three or four years after Harvey's
death, in 1657. But Harvey lived long enough to
see his views gain general acceptance, and though at
first, and as the result of the opposition provoked by
his publication, his practice fell off mightily, he later
regained his professional position and rose to the
highest eminence, being elected in 1654 to the Presidency
of the College of Physicians. To this institution
he proved a great benefactor, making considerable
additions to the building after its destruction in
The Great Fire of 1666 and its subsequent restoration.
He also left a certain sum of money as a foundation
for an annual oration, to be delivered in commemoration
of those who had been great benefactors
of the College. This oration is still regularly delivered
on St. Luke's Day, i. e., the 18th of October,
and is ordinarily known as the Harveian oration. In
these orations more or less reference to Harvey's work
and influence is always made.
This great man passed away on the 3d of June,
1657, within ten months of his eightieth birthday,
thus affording a brilliant exception to the list of men
who have rendered great service to the world and not
lived long enough to see it appreciated.
As one reads Harvey's own words, the wonder ever
grows that it should have remained for him, after the
lapse of so many centuries, to not only call attention
to what had been said by Galen but apparently forgotten
by his successors, namely, that "the arteries
contained blood and nothing but blood, and, consequently,
neither spirits nor air, as may be readily gathered
from experiments and reasonings," which he
elsewhere furnishes. He furthermore shows how
Galen demonstrated this by applying two ligatures
upon an exposed artery at some distance from each
other, and then opening the vessel itself in which nothing
but blood could be found. He calls attention also
to the result of ligation of one of the large vessels
of an extremity, the inevitable result being just
what we to-day know it must be, and the procedure
terminating with gangrene of the limb.
Not long before Harvey's own publication, Fabricius,
he of Aquapendente, had published a work on
respiration, stating that, as the pulsation of the heart
and arteries was insufficient for the ventilation and refrigeration
of the blood, therefore were the lungs
fashioned to surround the heart. Harvey showed how
the arterial pulse and respiration could not serve the
same ends, combating the view generally held, that
if the arteries were filled with air, a larger quantity
of air penetrating when the pulse is large and full,
it must come to pass that if one plunge into a bath
of water or of oil when the pulse is strong and full it
should forthwith become either smaller or much slower,
since the surrounding fluid would render it either
difficult or impossible for air to penetrate. He also
called attention to the inconsistencies between this
view and the arrangement of the prenatal circulation;
also to the fact that marine animals, living in the
depths of the sea, could under no circumstances take
in or emit air by the movements of their arteries and
beneath the infinite mass of waters, inasmuch as "to
say that they absorb the air that is present in the water
and emit their fumes into this medium, were to
utter something very like a figment;" furthermore
"when the windpipe is divided, air enters and returns
through the wound by two opposite movements,
but when an artery is divided blood escapes in one
continuous stream and no air passes."
Discussing further the views which he stigmatized
as so incongruous and mutually subversive that every
one of them is justly brought under suspicion, he reverts
again to the statements of Galen, calling attention
to the fact that from a single divided artery the
whole of the blood of the body may be withdrawn in
the course of half an hour or less, and to the inevitable
consequences of such an act; also that when an artery
is opened the blood is emptied with force and in
jets, and that the impulse corresponds with that of the
heart; again that in an aneurism the pulsation is the
same as in other arteries, appealing for corroboration
in this matter to the recent statements of Riolan, who
later became his avowed enemy. Harvey also called
attention to the fact that while ordinarily there was a
seemingly fixed relation between respiration and pulse-rate,
this might vary very much under certain circumstances,
showing that respiration and circulation were
two totally different processes. Harvey utilized also
the results of his researches in comparative anatomy
and physiology, for early in his work he called attention
to the fact that every animal which is unfurnished
with lungs lacks a right ventricle.
In his Proemium he then proceeds to ask certain
very pertinent questions which can only be briefly
summarized in this place. He asks: First, why, inasmuch
as the structure of both ventricles is practically
identical, it should be imagined that their uses are
different, and why, if tricuspid valves are placed at
the entrance into the right ventricle and prove obstacles
to the return of blood into vena cava, and if
similar valves are situated at the commencement of
the pulmonary artery, preventing return of blood into
the ventricle, then why, when similar valves are found
in connection with the other side of the heart, should
we deny that they are there for the same purpose of
prevention "here the egress" and "there the regurgitation
of the blood?"
Secondly, he asks why, in view of the similarity of
these structures, it should be said that things are arranged
in the left ventricle for the egress and regress
of spirits, and in the right ventricle for those of
blood?
Thirdly, he enquires why, when one notes the resemblance
between the passages and vessels connected
with the opposite sides of the heart, one should regard
one side as destined to a private purpose, namely,
that of nourishing the lungs, the other to a more
public function? Furthermore, he enquires, since
the lungs are so near, and in continual movement, and
the vessels supplying them of such dimensions, what
can be the use of the pulse of the right ventricle,
which he had often observed in the course of his experiments?
He sums up his inability to accept the
explanations previously offered with a phrase which
reads rather strangely, even in original Latin: "Deus
bone! Quomodo tricuspides impediunt aëris egressum,
non sanguinis." i. e., "Good God! how should
the mitral valves prevent the regurgitation of air
and not of blood?"
He then takes up the views of those who have
believed that the blood oozed through the septum of
the heart from the right to the left side by certain secret
pores, and to them he replied "By Hercules, no
such pores can be demonstrated, nor, in fact, do any
such exist." Again, "Besides, if the blood could
permeate the substance of the septum, or could be
emptied from the ventricles, what use were there for
the coronary artery and vein, branches of which proceed
to the septum itself, to supply it with nourishment?"
Further on in the treatise Harvey sets forth his motives
for writing, stating how greatly unsettled had
become his mind in that he did not know what he
himself should conclude nor what to believe from others.
He says: "I was not surprised that Laurentius
should have written that the movements of the heart
were as perplexing as the flux and reflux of Euripus
had appeared to Aristotle." He apologizes for the
crime, as some of his friends considered it, that he
should dare to depart from the precepts and opinions
of all anatomists. He acknowledged that he took the
step all the more willingly, seeing that Fabricius, who
had accurately and learnedly delineated almost every
one of the several parts of animals in a special work,
had left the heart entirely untouched.
Passing more directly to the actual work of the
heart, he shows that not only are the ventricles contracted
by virtue of the muscular structure of their
own walls, but further that those fibers or bands,
styled "Nerves" by Aristotle, that are so conspicuous
in the ventricles of larger animals when they contract
simultaneously, by an admirable adjustment, help to
draw together all the internal surfaces as if with
cords, thus expelling the charge of contained blood
with force. Later on he says that if the pulmonary
artery be opened, blood will be seen spurting forth
from it, just as when any other artery is punctured,
and that the same result follows division of the vessel
which in fishes leads from the heart. He furnishes
a very happy simile to prove that the pulses of the
arteries are due to the impulses of the left ventricle
by showing how, when one blows into a glove all
of its fingers will be found to have become distended
at one and the same time. He quotes Aristotle, who
made no distinction between veins and arteries, but
said that the blood of all animals palpitates within
their vessels and by the pulse is sent everywhere simultaneously,
all of this depending upon the heart.
It is in Chapter Five of the treatise that he gives,
probably for the first time, an accurate published account
of just what transpires with one complete cycle
of cardiac activity. The passage need not be quoted
here, but deserves to be read by everyone interested in
the subject, as who should not be? One sentence,
however, is worth quotation or, at least, a summary,
as follows: "But if the divine Galen will here allow,
as in other places he does, that all the arteries of
the body arise from the great artery, and that this
takes its origin from the heart; that all the vessels
naturally contain and carry blood; that the three
semilunar valves situated at the orifice of the aorta
prevent the return of the blood into the heart, and
that they were here for some important purpose,—I
do not see how he can deny that the great artery is the
very vessel to carry the blood, when it has attained
its highest triumph of perfection, from the heart for
distribution to all parts of the body."
His Chapter Six deals with the course by which
blood is carried from the right into the left ventricle,
and here one must admire the large number of experimental
demonstrations which Harvey had undertaken
upon all classes of animals, for he speaks even
of that which occurs in small insects, whose circulation
he had studied so far as he could with the simple
lens. Furthermore he described the prenatal circulation,
omitting practically nothing of that which is
taught to-day, showing that in embryos, while the
lungs are yet in a state of inaction, both ventricles of
the heart are employed, as if they were but one, for
the transmission of blood. In concluding this chapter
he again states briefly the course of the blood, and
promises to show, first, that this may be so and, then,
to prove that it really is so.
His Chapter Seven is devoted to showing how the
blood passes through the substance of the lungs from
the right ventricle and then on into the pulmonary
vein and left ventricle. He alludes to the multitude
of doubters as belonging, as the poet had said, to that
race of men who, when they will, assent full readily,
and when they will not, by no matter of means; who,
when their assent is wanted, fear, and when it is not,
fear not to give it. A little later on he says: "As
there are some who admit nothing unless upon authority,
let them learn that the truth I am contending
for can be confirmed from Galen's own words, namely,
that not only may the blood be transmitted from
the pulmonary artery into the pulmonary veins and
then into the left ventricle of the heart, but that this
is effected by the ceaseless pulsation of the heart and
the movements of the lungs in breathing." He then
shows how Galen explained the uses of the valves
and the necessity for their existence, as well as the universal
mutual anastomosis of the arteries with the
veins, and that the heart is incessantly receiving and
expelling blood by and from its ventricles, for which
purpose it is furnished with four sets of valves, two
for escape and two for inlet and their regulation.
Harvey then noted a well-known clinical fact, that
the more frequent or forcible the pulsations, the more
speedily might the body be deprived of its blood during
hemorrhage, and that it thus happens that in fainting
fits and the like, when the heart beats more
languidly, hemorrhages are diminished and arrested.
The balance of the book is practically devoted to
further demonstration and corroboration of statements
already made. A study of this work of Harvey's
illustrates how much respect even he and his
contemporaries still showed for the authority of Galen.
It shows still further how nearly Galen came to
the actual truth concerning the circulation. Had the
latter not adopted too many of the notions of his predecessors
concerning the nature of the soul (Anima)
and the spirits (Pneuma) of man, he might himself
have anticipated Harvey by a thousand years, and by
such announcement of a great truth have set forward
physiology by an equal period. Independent and
original as Harvey showed himself, he seems to have
failed to get away from the notion of the vapors and
spiritual nature of the blood which he had inherited
from the writings of Galen and many others. Nevertheless
he also alludes to this same blood as alimentive
and nutritive. We must not forget, however,
that this was years before Priestly's discovery of oxygen
and that Harvey had, like others, no notion of the
actual purpose of the lungs, believing that the purification
and revivification of the blood was the office
of the heart itself.
Along with its other intrinsic merits Harvey's book
possesses a clear and logical arrangement, the author
first disposing of the errors of antiquity, describing
next the behavior of the heart in the living animal,
showing its automatic pumplike structure, its alternate
contractions and the other phenomena already
alluded to, thus piling up facts one upon another in a
manner which proved quite irresistible. The only
thing that he missed was the ultimate connection between
the veins and the arteries, i. e., the capillaries,
which it remained for Malpighi to discover with the
then new and novel microscope, which he did about
1657, showing the movement of the blood cells in
the small vessels, and confirming the reality of that
ultimate communication which had been held to exist.
Malpighi discovered the blood corpuscles in 1665,
but it remained for Leeuwenhoek, of Delft, in 1690,
by using an improved instrument to demonstrate to
all observers the actual movements of the circulating
blood in the living animal. One historian has said
that with Harvey's overthrow of the old teachings regarding
the importance of the liver and of the spirits
in the heart "fell the four fundamental humors and
qualities" while Daremberg exclaims: "As in one of
the days of the creation, chaos disappeared and light
was separated from darkness."
It remains now only to briefly consider how Harvey's
great discovery was received. To quote the
words of one writer: "So much care and circumspection
in search for truth, so much modesty and
firmness in its demonstration, so much clearness and
method in the development of his ideas, should have
prepossessed everyone in favor of the theory of Harvey;
on the contrary, it caused a general stupefaction
in the medical world and gave rise to great opposition."
During the quarter of a century which elapsed after
Harvey's announcement there probably was not
an anatomist nor physiologist of any prominence who
did not take active part in the controversy engendered
by it; even the philosopher Descartes was one
of the first adherents of the doctrine of the circulation,
which he corroborated by experiments of his
own.
Two years after the appearance of Harvey's book
appeared an attack, composed in fourteen days by
one Primerose, a man of Scotch descent, born and educated
in France, but practising at Hull, in which he
pronounced the impossibilities of surpassing the ancients
or improving on the work of Riolan, who already
had written in opposition to Harvey, and who
was the only one to whom the latter vouchsafed an
answer. It was Riolan who procured a decree of the
Faculty of Paris prohibiting the teaching of Harvey's
doctrine. It was this same Riolan who combated
with equal violence and obstinacy the other great discovery
of the age, namely,—the circulation of the
lymph.
One of the earliest and fiercest adversaries of Harvey's
theory was Plempius, of Louvaine, who, however,
gave way to the force of argument and who
finally publicly and voluntarily passed over to the
ranks of its defenders in 1652, becoming one of Harvey's
most enthusiastic advocates.
Harvey's conduct through the controversy was always
of the most dignified character; in fact, he rarely
ventured to reply in any way to his adversaries, believing
in the ultimate triumph of the truths which
he had enunciated. His only noteworthy reply was
one addressed to Riolan, then Professor in the Paris
Faculty and one of the greatest anatomists of his age,
to whose opinion great value was always attached.
Even in debating or arguing against him, Harvey always
spoke of him with great deference, calling him
repeatedly The Prince of Science. Riolan was, however,
never converted, though whether he held to his
previous position from obstinacy, from excess of respect
for the ancients, or from envy and jealousy of
his contemporary, is not known.
Another peculiar spectacle was afforded by one
Parisunus, who died in 1643, a physician in Venice,
who, like Harvey, had been a pupil of Fabricius of
Aquapendente, who had been stigmatized by Riolan
as an ignoramus in anatomy, but who joined with others
in declaring that he had seen the heart beat when
perfectly bloodless, and that no beating of the heart
and no sounds were to be heard as Harvey had affirmed.
With the later and more minute studies into the
structure and function of the heart we are not here
concerned. The endeavor has been rather to place
before you the sentiments, the knowledge and the habits
of thought of the men of Harvey's time, with the
briefest possible epitome of what they knew, or rather
of how little they knew, to account for this later slavish
adherence to authority by unwillingness to reason
independently, or to observe natural phenomena
intelligently, still less to experiment with them. It is,
then, rather the brief history of an epochal discovery
than an effort to trace out its far-reaching consequences
that I have endeavored to give.
Here must close an account which perhaps has been
to you tedious, and yet which is really brief, of Harvey's
life and labors. He lived to see his views generally
accepted and to enjoy his own triumph, a pleasure
not attained by many great inventors or discoverers.
Lessons of great importance may be gathered
from a more careful study of this great historical
epoch, but they must be left to your own powers of
reasoning rather than to what I may add here. I
commend it to you as a fertile source of inspiration,
and a line of research worthy of both admiration and
imitation. Few men have rendered greater service
to the world by the shedding of blood than did Harvey,
in his innocent and wonderful studies of its
natural movement. Perhaps it might be said of him
that he was the first man to show that "blood will
tell." What he made it tell has been thus briefly told
to you.
I know not how I may better close this account than
by quoting the concluding words of his famous book,
and especially repeating the lines which he has quoted
from some Latin author whom I have not been able
to identify. His paragraph and his quotation are as
follows:
"Finally, if any use or benefit to this department of
the republic of letters should accrue from my labors,
it will, perhaps, be allowed that I have not lived idly,
and, as the old man in the comedy says:
'For never yet hath anyone attained
To such perfection, but that time, and place,
And use, have brought addition to his knowledge;
Or made correction, or admonished him,
That he was ignorant of much which he
Had thought he knew; or led him to reject
What he had once esteemed of highest price.'"