The Commonwealth of Cells

CONTENTS

INTRODUCTION

The unscientific public is extremely prone, and not altogether without reason, to take medicine as a starting-point, and arrange all biological science around it. As it is, moreover, apt to gauge the interest and utility of every branch of this science from a practical point of view, and bestows most attention upon that which it imagines is of the greatest service to the doctor, I think a series of popular essays on physiology could not commence with more advantage, at any rate to physiology, than by briefly discussing, not with what it deals, for that is pretty generally known, but what is its relation to medicine. Further, as the doctor is more easily discussed than medicine, the physiologist will be more manageable for our immediate purpose than physiology in the abstract, so we will devote the first few pages to the question of how his labours benefit the patient.

Everyone knows the doctor, and everyone knows that physiology deals with the ‘functions of different organs of the body’; but the public rarely meet the physiologist, except in the fanciful caricatures of his enemies, which though frequently personal are rarely accurate. These rancorous libels, if anyone heeded them, would tend to raise doubts as to whether the physiologist was a good companion for the doctor, and if it were not as well for them to see as little of each other as possible.

The doctor, however, cannot move a step without the physiologist. His business is to correct the revolt of any organ from its allotted task, and repair the damage done by its deviation from the normal path. This he cannot possibly do if he does not know what that organ’s normal conditions are, and what they are it is the physiologist’s duty to tell him. A doctor, therefore, should be an enlightened physiologist, knowing how the body ought to work, and referring diseases to their real cause, such as the poisons formed by an invasion of bacteria or otherwise, or wrong feeding—that is to say, deficiency or excess of fuel for one of the body’s many engines. Medicine is still to a large extent rule of thumb. We don’t know to what many diseases are due, or why certain things relieve them, if any remedy is known; and until these questions are satisfactorily settled, it is vain to hope that disease as a whole can be successfully combated. It is no use knowing what will stop certain unpleasant symptoms if we do not know how to remove their real cause, and for this end the whole body and every individual component organ is being studied, that the process of life may be accurately understood; and the man who is doing this for his friend the doctor is the physiologist.

The physiologist has many enemies, a motley array of cranks held together by such noble bonds as general hatred of science and prejudiced ignorance masquerading as scepticism; but he can afford to ignore them, for the very good reason that people cannot get on without him. It is only on account of this that they are mentioned. People say, ‘The doctor is the person who requires a knowledge of physiology; he is the man who is most likely to study it successfully’—presumably by his mistakes—‘and not waste more time on it than is necessary,’ a point about which they are most solicitous. The doctor, however, prefers to trust the physiologist. If he did not, he would have very little time to do anything else. You might as well expect a tailor to make his own cloth before he makes a coat. He will doubtless be able to make better coats if the quality of the cloth supplied him is improved; but if in order to improve the finished article he lays down his scissors and applies his fingers to weaving, his business will be sure to suffer.

That physiology is a thing which can take up a man’s whole energies will, I think, be admitted by anyone who realizes how wide is its scope. The physiologist himself must specialize, for the subject is too vast for one man to undertake the whole. The body is composed of the same elements as the rest of the world, and their arrangement is very important, so he must be a proficient chemist. It is composed of solids, liquids and gases, and diffusion, filtration, leverage, are frequent processes, and every motion is accompanied by an electric manifestation, so that mechanics and physics must have been part of his training. He can scarcely study organs if he does not know their shape, so he should know some anatomy. And, lastly, as his business is to study life and all its attendant phenomena—and the basis of life is the cell—he must be a histologist. To be all these things is a great deal to require of one man; but though he may specialize for the advancement of a particular branch of his science, he must be au fait with the rest, as no vital function is dependent upon one alone of the factors enumerated. Hard work is required of him, though some people say he has done but little. What he has discovered is briefly, very briefly, set forth in the ensuing essays, with a hint or two at the knots he would like and is trying now to unravel.

THE COMMONWEALTH OF CELLS. Some Popular Essays on Human Physiology.

ESSAY I. LIVING MATTER.

ESSAY II. THE CHEMISTRY OF THE BODY. — I. — II. — III. — IV. — V.

The cell is usually very minute—indeed, absolutely invisible without a microscope, though in some cases it is a fair size. The whole yolk of an egg is a single cell until its minute nucleus, a speck on one side, starts dividing and it becomes several. By the time the chick is ready to be hatched there are millions.

Usually, however, a cell is small—just as much protoplasm as its still more minute nucleus can keep going; though here, again, one must be guarded, for there may be several nuclei instead of only one. The protoplasm on the external surface and around the nucleus is specialized into a more or less definite membrane. To this outer envelope are attached fine fibrils, which join up to a small body within the cell, called the centrosome, and by the lengthening and shortening of these its shape can be altered. The contents are fluids; so if the containing membrane is loosened in any direction, they tend to bulge out and form an excrescence, and in this way the cell is enabled to throw out limbs and surround particles of food, and, by relaxing the fibrils in one direction and contracting them in others, to crawl whither its chemical, thermal, or physical affinities direct. (See Diagram 1.)

Not particularly inspiring is the sight of life in its simplest form, but when a few millions of these cells group together and form one body, dividing the labour between them, the result is something stupendous. There are animals composed in this way, some of whose cells have developed their digestive capabilities to such an extent that they have almost lost all their others. These are carefully guarded in the interior of the body. Other cells in this same beast, receiving their food in a fluid form from these digestive specialists, secrete lime around them till a skeleton is built up. To the levers of this skeleton are attached bundles and strands of cells, which, if they can do nothing else, can lengthen and shorten and make it move. Yet, again, there are cells which have especial facilities for receiving, weighing, and transmitting chemical and physical promptings. These cells, again, lie in a protected corner of the interior, but they send out fine threads to one another and every part of the body, and control the whole.

The animal in which this beautiful system of division of labour has been carried to its greatest perfection has many and varied powers. He can in some cases even apply to the individuals of the species the principles of his own cellular economy, and thereby achieve not only the making of poetry and jokes, but the building of a Westminster Abbey, the construction of Maxim guns, and the enforcing of his economic refinements upon his less highly specialized neighbours.

We have now traced out a general idea of life. We have seen that its basis rests upon a chemical structure which, to maintain its identity, must be always changing. We have seen that to do this it must keep breaking down its substance, and giving off the products, and taking hold of extraneous materials, and building them in, not only to repair the loss, but in order to grow; and that to do that it has to be more or less modified in parts, in order that the main bulk may be brought within reach of its food, and be then able to convert it into the most useful form. And, lastly, we have seen that just as several specialized forms of plasm together make up a cell, so several kinds of cells, each with some peculiarity exaggerated, aggregate, and, supplying one another’s needs, compose a body.

Having now roughly sketched out the scheme upon which such a body works, we can go on to a more detailed examination of the division of the labour, and the way in which each department supplies, and is dependent upon, the others. If we were to do this thoroughly, it would take a great deal of time and space, for the physiology of a potato plant, though essentially the same, presents many differences from that of a horse; but the physiology of the great human interest is also that of the most complicated animal, namely, man, so it is on him that we shall focus our attention.

Protoplasm is more easily studied the more specialized is the animal it composes. When all the events of life are taking place in a speck of matter, invisible without a microscope, it is impossible to analyze the changes which it is working in its surroundings, or to infer those which are going on in itself. But when large numbers of cells are examined collectively, we can deal with what they take in and what they give out in sufficient bulk to arrive at a fairly accurate determination. The study is rendered still easier in an animal with extremely specialized organs, like man, in which food is nearly all taken in by the mouth, and thus kept quite distinct from what is eliminated; the latter, again, being mostly given off by the kidneys is kept equally distinct. Moreover, the intermediate changes being performed in different organs still further simplifies investigation of the vital process; for the physical effects are also more easily studied when exaggerated in a particular part of the animal. The electrical changes in a single cell might long have remained unsuspected had we not been able to observe those in a muscle with the galvanometer.

Now, while the cells which make up the body of man differ very greatly owing to the different tasks which they have to perform in obtaining food and getting rid of refuse, they all require very much the same fuel to enable them to live, and having got it, they all treat it in very much the same way; therefore our first business is to consider what the body wants, and what it does with it. Afterwards we can try to find out how it gets it, and where.

The first and most indispensable requirement of protoplasm is water. The next is probably nitrogen, compounds of which seem to form the framework of the protoplasmic structure. The next is probably carbon, and the next free oxygen. The two last-mentioned combine with a release of energy. This happens in the grate when coal burns, and the result is heat. In the tissues of a body the result may be heat, growth, or movement, all three being present in the phenomenon of muscular activity. Finally there are mineral salts, the most important being sodium chloride, which is placed on the table at every civilized meal.

But though these elements are given here in order, their importance is really equal, for all are necessary. That is about as much as it is wise to say here. The chemistry of the living cells—their anabolism, or how fresh material is built into their structure; their katabolism, or how the same structure is broken down that work may be done; in fact, the general metabolism—is so complicated, and so little understood as yet, and requires so extensive a knowledge of chemistry to follow, that it is best left alone by people who do not want to go into it deeply. At best, such a discussion resolves itself into an exposition of different observers’ theories, with the reasons why they hold them—reasons based on laborious and technical studies. Pages might be written on the various theories, backed by pages more of chemical formulæ, to show why this view deserves deep consideration, while that, in spite of the obstinacy with which it is upheld, is absurd; but though such discussions take one nearest the secret of life, the general public is not unnaturally apt to stigmatize this side of physiology as dry. It is a matter which interests experts, not the casual reader.

Quite a different affair is the question of diet. That is everybody’s business, as the number of faddist societies and blatantly advertised ‘foods’ attest. And though the preparation of the food in the body up to the point where it merges into living matter and is lost sight of—in a word, ‘digestion’—is again a question of chemistry, it is one which may be approached without such an exhaustive knowledge of that science as the previous considerations would have required. It is, moreover, to judge from the way it is discussed, a topic of universal interest.

A casual glance at the animal kingdom will show that diet is a wide subject. A pigeon will eat peas; a tiger would not know what to do with the peas if he got them; while a monkey will eat almost anything he can lay hands on. A plant takes us still further afield, for it can use the atoms of substances with an extremely simple molecule—carbonic acid gas, for instance.

Our task, however, is simplified by our having only man to consider; and although most of the higher animals are so much alike that they might be considered in general and contrasted in detail, it is a great thing to get rid of the whole vegetable kingdom with bacteria and parasitic animals.

One of the first requisites for the maintenance of life, as was mentioned above, is nitrogen. Now, nitrogen is one of the commonest elements in the world, but it is the hardest to supply to the body. Four-fifths of the air is pure nitrogen, but pure nitrogen is useless as a food. We draw it into our lungs at every breath, and are none the better for it, for we breathe it out again unchanged; and if it were completely absent from the air we should not be so very much the worse. The Ancient Mariner exclaimed, ‘Water, water everywhere, and not a drop to drink’; a starving man might exclaim, ‘Nitrogen, nitrogen everywhere, and not an atom to assimilate.’

Animals have to get their nitrogen in the form of proteid, a substance whose molecule is composed of nitrogen, oxygen, hydrogen, carbon, etc., and might roughly be described as dead protoplasm. Plants on which animals feed, when they do not get their proteid by the simpler, though less moral, method of eating one another, are able to get their nitrogen in a simpler form; but with that we are not concerned.

The proteids are a group of substances which resemble protoplasm in the elements of which they are composed and in the complexity with which they are combined. The various proteids seem, however, to have a definite chemical composition, and therefore differ from protoplasm in being true compounds; moreover, if kept from bacteria they undergo no changes. One of the best forms of proteid for examination is white of egg; this, as is known, sets or coagulates when boiled, dissolves in water, from which it may be precipitated by boiling, and displays various other chemical properties common to all proteids. There is, however, a good deal of difference between the several varieties of proteids, and the more complex ones have to be converted into the simpler before they can be absorbed. Hence the necessity for digestion.

Now, as proteid resembles dead protoplasm, it might be supposed that a diet of proteid alone would be the most economical; but this is not so. If it were possible to live without work, i.e., without movement of any kind, it might be; but to do work, more carbon must be oxidized than the proteid molecule contains.

Carbon, the next item on our list, is familiar to everyone in the comparatively pure form of coal, charcoal, and the ‘lead’ of pencils. It is commonly used to burn—i.e., oxidize—that heat may be obtained to boil water and to work machinery. This is precisely what it is required to do in the body, where it is burnt by oxygen taken in by the lungs, that heat and energy may result. It is a commonplace that severe exercise causes laboured breathing, and the reason of this is that the carbon in the body is being oxidized, and the product, carbonic acid gas, has to be got rid of. The more work is being done, the more oxygen is required to burn carbon in the muscles. The more carbon is burnt, the more heat is evolved, and the more necessary it is that the blood should be cooled by drawing cool air into the lungs. Hence the more rapid breathing. The air normally breathed out is always warmer than that taken in, and always contains extra carbonic acid gas. After exercise the quantity is increased, and its increase on the normal amount given off can readily be demonstrated by analyzing samples of the air taken in and given out.

But carbon, like nitrogen, cannot be taken in in the crude form. No one would try to make a meal of charcoal. A certain amount is contained in the proteid molecule, enough, no doubt, to secure the basis of the protoplasmic structure; but unless one is prepared to eat an excessive quantity of proteid, a proceeding entailing waste and exhaustion of the digestive apparatus, the balance must be made up by eating carbohydrate.

The forms in which people are most familiar with carbohydrate are starch and sugar. Sugar is the better food, as it is so much more soluble than starch; and, in fact, starch is always turned into a kind of sugar before it is used by the body. The common cane-sugar, which everyone knows so well, is about the most useful food we have, owing to its purity, and therefore concentration, and its simplicity. A very small amount of digestion is necessary to convert it into the simplest of all carbohydrates, a substance easily stored, as glycogen, till wanted, which is present in muscle after a meal, and is used up when the muscle is active, being oxidized to carbonic acid gas, sarcolactic acid, and alcohol.

The importance of carbon in the diet is therefore obvious; and people who intend doing extra muscular work should take extra sugary food rather than extra proteid. A locomotive which is about to make a record run takes in more coal, not more engine-drivers, and our athletes now follow the same principle. We shall, however, have a good deal more to say about athletes presently.

There is yet another point to be considered in respect to carbon. Carbon need not be taken in the form of carbohydrate, the alternative being fats and oils. Fats and carbohydrates are both composed of the elements carbon, hydrogen, and oxygen, but the proportions in which they are joined are different. Fats are not such useful foods as carbohydrates, nor to most people so pleasant—compare a spoonful of olive-oil and a lump of sugar. But there is one important point to be urged in their favour: they yield twice as much heat as either proteids or carbohydrates; so their position among foods is assured.

The other chemical necessities of the body we need only mention here. Hydrogen is one of the components of proteid, carbohydrate, fat, and water; and if it does not enter in the last form, it—at any rate, most of it—leaves as such, being oxidized in the tissues. Sulphur and iron deserve honourable mention; common salt is required by the blood; lime and phosphates go to make bone; but important as they all are, they need not detain us further at present.

With regard to the amount of these elements which is required per day, and which is ascertained by collecting and weighing all that is given off, it is found that about ½ ounce of nitrogen and 10 ounces of carbon are necessary to an average man—i.e., weighing about 10 stone. The ½ ounce of nitrogen and about 2 ounces of the carbon are contained in 4 ounces of dry proteid, which leaves a balance of 8 ounces of carbon to be made up; and this is usually obtained by eating 4 ounces of fat and 18 ounces of carbohydrate.

Roughly speaking, these principles are contained in ¾ pound of ordinary butcher’s meat and 2 pounds of bread; but it would be well to defer considering diet for the present, until we have examined the apparatus by which the body extracts what it wants from the raw materials, and which of these offer it the least resistance.

The way in which protoplasm gets its chemical requisites for growth is doubtless simply by absorbing them. Some of the lower structureless forms carry this to an absurd extreme, for when two individuals meet they fuse, and each no doubt claims to have eaten the other. As, moreover, the first thing which a cell does when it grows is to divide, the whole proceeding looks rather futile. But ready-made protoplasm of an assimilable shape is rare, and it is not often that a cell, unless it be a plant or a parasite, finds itself in a substance which can be handed straight to the nucleus without further elaboration. Usually the cell has to discharge from itself a reagent, which will develop the right chemical qualities in the matter it wants to absorb. This substance is known as an enzyme, or ferment. Ferments, however, are an expense to the cell, requiring a certain effort for their production; so, in order that they may be economized, they are, in the higher forms, poured over the food while it is in an enclosed cavity, or stomach. In the simplest animals, consisting of a single cell, the protoplasm simply flows round the particle of food, and it is ‘ingested’ with a drop of water. Into this ‘food vacuole’ the ferments are secreted, and when all that is useful has been dissolved out and absorbed, the bubble moves to the surface and bursts; or, to put it differently, the cell flows on its way, and the vacuole, with any shell or refuse it may contain, gets left behind. (See Diagram 1.) In other cells which are constant in shape there is an opening leading to the interior of the cell. Round this there are little projecting threads, which beat the water regularly. In some positions these threads enable the cell to swim, but here their duty is to cause a current and wash particles of food down the primitive throat into the interior, where, as in the preceding case, they become enclosed in a vacuole. (See Diagram 2.)

Moving a stage higher, we find animals consisting of several cells. Of these it is only natural to suppose that some have greater enzyme-forming powers than others.

A step higher in the animal scale, or a further advance in the development of the schematic embryo (depicted in Diagrams 3 to 6), and we find that these special digestive cells are losing their sturdier qualities and being placed in a position protected by cells which have specialized in another direction. This is shown in Diagram 4, where the hollow ball of cells which resulted from the repeated division of one cell is represented in section. One side of the ball is pushed in, and now the beast consists of two layers of cells, an outer protecting and an inner digesting (Hydra and sea-anemone). Soon, however, it is found more convenient to have a tube for digesting food, for then different substances can be digested and absorbed in different parts; and the refuse, of which the animal can make no use, need not be brought back to the mouth to be got rid of.

This, however, requires a number of other changes in the structure of the animal, which are roughly shown in Diagrams 5 and 6. It is not to our purpose here to discuss the development of animals or an animal; but the figures are worth glancing at, as they show not only how certain of the cells are set apart for digesting food, but also that a large body consists really only of a mass of protoplasm, composing kindred cells of common origin.

Now, for obvious reasons, the longer, within certain limits, this tube is the better. All sorts of different food-stuffs have to be acted upon in it, and some offer considerable resistance to digestion; and the further they have to travel in the tube, the more chance there is of their being successfully treated. Besides, different parts have different functions, and the longer the tube—again within necessary limits—the greater scope is there for division of labour, and consequent economy. The comparative length of the alimentary canal is not the same in all animals by any means. Carnivorous animals, like the cat, whose food is soft and easily digested, have a fairly short one. Herbivora, like the sheep, whose food is difficult to digest and mixed with much husk, which is wholly indigestible, have a comparatively very long one. Man, who is omnivorous, but eats less and more judiciously chosen food than either of the above classes, has one of medium length. But in all cases among the higher animals there is an attempt made to obviate the necessity of increasing the length of the animal by coiling the tube within the body. The annexed diagram (7) illustrates this principle. It shows a schematic animal whose digestive canal is much longer than itself.

The digestive canal has, however, another function. The cells which compose it have not only to secrete juices, to convert the food into a usable form; they have then to absorb it. The nearer a particle of food is to the wall of cells, the sooner it is reached by these juices, and the less chance there is of useful material being swept away and lost. In view of this fact, along certain tracts the digestive canal is folded inwards, and there are projections, which increase the number of cells to secrete and their opportunities of absorption. (See Diagram 8.)

Here again we have an illustration of a constantly recurring need, with a device for meeting it—increase of surface without increase of bulk. We met with it before in the cellular system; we shall meet with it again in glands, lungs, and brain, at least. The importance of a device for gaining this end is apparent when one remembers what the comparative value of surface and bulk is to an animal, and that, while surface increases by the square, bulk increases by the cube.

The principle is pressed to an extreme, together with the allied principle of division of labour, in glands. The object of these is to increase the number of secreting cells, and, as they are delicate, to keep them protected from contact with coarse particles of food. And, in order that nothing may interfere with their efficiency, they are absolved from the duty of absorbing. Hence tubes grow out from the cavity of the alimentary canal lined with the same cells, but, as no food ever enters, the cells which line them devote themselves entirely to pouring out digestive juices. Glands differ considerably in structure and in the liquids which they secrete. Some are very small; some, like the liver, very large. In some the tube is very short, in some long, coiled and branched, and sometimes the gland is connected with the surface by more or less of a duct. Some glands only secrete one enzyme, some several. In each, however, the principle is that shown in Diagram 9, no matter how its structure is masked by the bloodvessels and supporting cells or connective tissue which envelop it.

After a meal, or, rather, when the process of digestion is over and the animal is beginning to think about its next, the gland cells start preparing their enzyme. There is great activity in the nucleus, and granules stream out from it towards the lumen of the gland in much the same way, to take a homely illustration, as bubbles in some effervescing drink form at the bottom of the tumbler and rise till the surface is covered with foam. At the right moment these granules are discharged, just as the bubbles on the surface of a liquid break at a slight jog. They are usually not the ferment or enzyme, but its precursor, a substance which only turns into the ferment when it gets outside the cells. The ferments, when formed, are very peculiar substances about which we should like the chemist to tell us more, though great advances have been made in our knowledge of them lately.

Among other peculiarities, one may mention that, though they will keep indefinitely if bottled, they are easily destroyed by too extreme a temperature or too acid or alkaline surroundings, that their composition is entirely unknown, and, strangest of all, that they do not become used up. A given amount of rennet will clot any amount of milk within reasonable limits, and yet remain rennet. The clergyman has been quoted as an illustration of the action of a ferment, and he makes a good one. He can make any number of suitable men and women into married couples, and yet his own state is unchanged.

In man, the digestive process may be divided into three stages. They are arranged progressively, so that each clears the way for the next, and take place in the mouth, the stomach, and the upper part of the small intestine, the rest of the canal being mainly occupied in absorption.

By far the largest proportion of the food is carbohydrate, in some form, so one naturally expects the first stage of digestion will deal with the constituents which represent this class. This is the case. The food is taken into the mouth in small quantities and ground up with the teeth, during which process it is subjected to the action of the saliva. This fluid, which is the secretion of three pairs of glands, converts a large proportion of the carbohydrates, starch, cane-sugar, etc., into a very simple sugar which is absorbed directly it reaches the stomach.

One of the most sensational discoveries of the physiologist has been that the saliva leaving the gland does not contain the ferment necessary to effect this change until it has been subjected to the action of putrefactive bacteria. These, fortunately for us, it is pleasant to know, simply swarm in the mouth.

When the food is swallowed, it passes very rapidly down the first part of the alimentary canal, which is straight, and is then kept for some time in the stomach. The stomach differs from the rest of the canal in several particulars, among them the following: it is a large cavity, and is closed at each end by a valve to keep the food in until it has been thoroughly treated, and it deals with the whole mass of food taken at a meal at one time, and yet has no contrivances for increasing its surface.

Here the food is subjected to a most important and searching examination. Enclosed in this bag, it is thoroughly mixed with weak hydrochloric acid, secreted by numerous glands, and kept churning round and round by the muscular action of its walls, that the contents may be kept well mixed. The acid is just strong enough to kill protoplasm, and hence the putrefactive bacteria which were necessary in the mouth, but would be a very doubtful blessing in the interior of the body, are disposed of. Other things are also killed. Not only does the stomach execute intruding bacteria, but it also kills a good deal of our food. Fruit and salad consist largely of still living cells, and occasionally there is bigger game, e.g., oysters. One thing, however, the acid does not kill, and that is the cells lining the stomach, and it may as well be said here that the parts of the body exposed to ferments have the very necessary power of resisting them, so that a normal animal does not digest itself.

The stomach, however, is a kitchen as well as a slaughter-house. The gastric juice, or secretion of all the glands opening into it, contains, besides the acid, two important ferments, both of which act on proteids. Carbohydrates are absorbed, but not digested, in the stomach, as acid destroys saliva. One of the ferments is rennet, an article familiar to the culinary profession, which solidifies milk. The other acts on proteids generally, converting them ultimately into a very simple form, peptone, which is absorbed at once. How much of the proteid in the stomach is converted into peptone is not known, for the action of acid alone is sufficient to enable it to be absorbed. A solution of proteid, e.g., white of egg, is quite altered if made slightly acid; it no longer coagulates when boiled, but the change of the most practical interest is that, if injected into the veins, it seems to become part of the blood, while ordinary proteids act as poisons.

The peptonizing ferment, however, has one very important function: it digests the collagen of the connective tissue, the substance which becomes gelatin when boiled. The reason why this is so important is not only that nothing else in the body affects it, but that fat is enclosed in it, and if it were not thus set free would pass through the body unabsorbed.

The final stage is the digestion by the pancreatic juice. After the food has been exposed for some time to the gastric juice, it is allowed to escape a little at a time from the stomach, and continues its way along the alimentary tube. Before it has gone many inches it comes to the openings of two ducts, those of the liver and the pancreas, and immediately the acid stimulates them, and the glands pour out their secretion. That of the liver is largely excretion or refuse from the blood without direct action on the food, but it enables the pancreatic juice to do its work by making the food again alkaline, and stimulates the muscular coats of the intestine to force its contents along. That of the pancreas is the most important digestive fluid in the body, containing many ferments; it acts alike on proteids, carbohydrates, and fats—in fact, digests everything—so that the rest of the long tube is freed from any more laborious duty than absorbing them as they pass.

Note.—The digestive ferments are now prepared for examination by chopping up the gland and placing it in glycerine; this extracts the ferment and preserves it from the action of bacteria. The first experiments on digestion, however, constitute one of the romances of physiology. A Canadian named St. Martin got into trouble with Red Indians whilst in the United States, America, and was shot through the body. The surgeon who attended him was unable to make the wound close, and when it healed there remained an opening in the man’s body communicating directly with his stomach. The surgeon, Beaumont, saw possibilities in this, and, obtaining gastric juice from his patient, made those classical experiments which entitled him to a place among the fathers of physiology. Americans do well to be proud of Beaumont, for it cost him many sacrifices, and his patience and courage are above praise. Not only was he devoid of all but the crudest appliances out in the backwoods, but his subject proved intractable and mercenary. No sooner did he discover his value than he crossed the border, and refused to return except upon exorbitant payment. Even after this had been arranged, he repeated the performance whenever he thought fresh extortion possible. In spite of these difficulties, the investigations proved wonderfully accurate and complete.

Of the absorption of the materials thus prepared it is not necessary to say much in a work of this compass, but the absorption of oxygen is too important to be passed over.

Oxygen is required by the body pure, and, as it is uncombined with anything in the air, it needs no digestion to free it. A special organ, however, is necessary to absorb it. This is the lung. The lungs originate, just like a gland, by a pouching of the alimentary canal near its origin, but differ from a gland in their cells being very much flattened, to offer a large surface to the air on one side and to the bloodvessels on the other. Incessantly during life air is being drawn into the lungs; that the cells to which it is there exposed may transfer its oxygen to the blood; and then, after the cells have also transferred the carbonic acid gas from the blood to the air, driven out again to be replaced by fresh.

(The mechanical means by which the lungs are filled and emptied come under another heading.)

Food having been absorbed by cells set apart for the purpose, the next problem is, How is it distributed to those specialized for other work? The medium for this distribution is a liquid called lymph. All the spaces in the body are filled with lymph, all the organs bathed with it, every cell moistened with it; yet it is comparatively stagnant, and the food has to be conveyed from the walls of the alimentary canal to the lymph in the neighbourhood of the cell requiring nourishment by a more expeditious agent. This is done by the blood.

The blood is a fluid akin to the lymph, but confined in a system of tubes. Through these tubes it is driven at a considerable velocity, and in the course it takes passes within a reasonable distance of every cell in the body. As it passes the cells of the alimentary canal, they discharge the nutriment they have absorbed into it; as it passes through the other organs of the body, it discharges the requisite materials into the lymph bathing the actual cells: these are then able to help themselves.

The lymphatic system is very simple. Lymph is practically fluid which has exuded through the walls of the bloodvessels, and is like the plasma of the blood, a thin solution of proteids in water containing just enough salt to hold them in solution. From different parts of the body a series of tubes run towards the heart, going up with increase in size and decrease in number as they near it. Into these tubes the lymph is forced with every movement of the body. At a slow rate, but varying with the activity of the animal, it is forced to flow along these tubes, regurgitation being prevented by valves at intervals, until it reaches the place where the lymphatic vessels join a large vein, and it is poured back into the blood-stream, thus completing its cycle.

The blood is entirely confined in a closed system of tubes, along which it moves always in the same direction. The main principle of the system is that of a ring. One side of the ring is split into a vast number of fine tubes to give a large surface for absorption and discharge of food among the cells; the other side is a single tube, with an enlargement in which the blood from different parts is mixed (see Diagram 11). This enlargement, which is contractile and fitted with valves, rhythmically draws the blood in from one direction and pumps it out in another. (The mechanics of the process we shall study later.)

As a matter of fact, this system is twofold, as in Diagram 12. In passing through one-half of its course the blood absorbs oxygen in the lungs; in the other it yields oxygen to the tissues, and absorbs, whilst passing over the alimentary canal, proteid, carbohydrate, water, and salts, which are duly distributed to the other organs. Fat is absorbed by the lymph direct, but poured into the blood for distribution.

The blood which passes over the alimentary canal on its way back to the heart goes through the liver. In this gland it leaves the carbohydrate which it has taken up, and a large store is laid down there after a meal, to be doled out as it is wanted. Blood also passes through the liver from the spleen, where it has been, so to speak, overhauled for repairs.

As the medium for chemical communication throughout the community of cells, the blood has another all-important and obvious function, viz., that of clearing away the waste products of life. Of these there is, of course, the same quantity as of new material introduced. Carbonic acid gas is discharged into the lungs, but all the nitrogen and most of the other elements in the new combinations which protoplasm has made them assume leave by the kidneys, plus a little water by the skin as sweat and a few items discharged into the last part of the alimentary canal amongst the unabsorbed portions of the food.

In their constituents, blood and lymph resemble one another, being both weak solutions of salts and proteid material; but the blood is distinguished from the lymph by the presence of innumerable extremely minute bodies, which give it its red colour. These corpuscles, to give them their proper name, are the vehicle by which oxygen is transported from the lungs to the tissues. They consist of an envelope of protoplasm filled with a red fluid (hæmoglobin), which combines loosely and easily with oxygen. In shape they are discoid, with a thickened rim and biconcave sides, another device for increasing surface and reducing bulk. (See Diagram 14.)

With one more fact we may now conclude the chemical survey of the body. The blood has to pass through certain glands, or it becomes poisoned, and this quite apart from whether the gland secretes healthily or not.

Disease of the thyroid (a ductless gland in the Adam’s apple) causes goitre; of the suprarenal, Addison’s disease; of the pancreas, diabetes. Whether these organs secrete some substance into the blood which counteracts poisons formed in it, or whether they remove injurious elements from it, is not certain, but they are necessary to keep the great means of chemical communication in order.

Note.—The thyroid gland no longer secretes anything into the alimentary canal, and its duct disappears at an early age. If, however, it become diseased or is surgically removed, the distressing symptoms of goitre supervene. Such a patient may be completely cured by grafting a thyroid, excised from another animal, anywhere in his body. Doctors usually, however, give the patient extract of sheep’s thyroid either in pills or injections.

ESSAY III. THE MECHANICS AND PHYSICS OF THE BODY. — I. — II. — III. — IV. — V. — VI. — VII.

In the preceding essay we regarded protoplasm as a chemical factor in the universe.

We have seen how it is always changing, always taking in food, always giving off waste materials. We have seen, too, that it grows and that it does work, and that in a large mass the cells which compose it share the labour instead of each component cell performing all the vital functions. We have now to consider the work which protoplasm does—in a word, the mechanical effect of the chemical actions just described.

The simplest movement of protoplasm is to be seen by the aid of the microscope in certain vegetable cells, where granules seem always streaming about in different directions. A step higher, and we find this streaming movement converted into movements of the whole cell. In the simplest unicellular animals the fluid protoplasm is contained in a membrane, or denser bounding layer, to which are attached fine filaments springing from a minute body known as the centrosome. These centrosomes—for there are sometimes several in a cell—seem to control the mechanical department, just as the nucleus does the chemical. Along the fibrils at intervals are minute globules, and by watching the distance between them it is seen that the fibrils undergo changes in length, pulling in the membrane when they shorten, and letting the cell flow out in any direction when they relax. By adjusting these two movements to balance one another, the cell can move in any direction, surround and engulf particles of food, and assume a strange variety of shapes. (See Diagram 1.)

In some cells, probably in all, the centrosome presides over division. Cells, however, do not always divide in the same way. Some simply lengthen, the nucleus also lengthening inside, become constricted in the middle like a dumb-bell, and separate. (See Diagram 15.)

Others manage differently. In them the nucleus simply bursts, and turns its essential elements, a number—always a constant number—of coarse threads, adrift. Meanwhile, two centrosomes have moved to opposite ends of the cell, and there anchored themselves by fibrils; other fibrils springing from them become attached to the nuclear threads, and when all is ready pull them apart, equally divided, to their respective ends, where they re-form into two fresh nuclei. (See Diagram 16.)

Unicellular animals, which are constant in shape and swim instead of flowing when they want to get anywhere, have at first sight nothing in common with those which do the latter. From their surfaces spring fringes of free protoplasmic threads, called cilia, from their fancied resemblance to eyelashes, which serve as motor organs, and beat the water like oars. (See Diagram 2.) Waves of movement, as they lash one after another, all in the same direction, seem to pass over the cell, and it is propelled through the water; while others, which are situated in the neighbourhood of the cell’s mouth, stir the water into eddies, and drive food particles into it.

These cilia are important, as they are adapted for many purposes in large animals. The cells which line the cavity at the back of the nose, the tubes of the lungs, and other parts of the body, have a few cilia on their free surface, and it is in them that the structure of these organs can best be made out. At the foot of each cilium is a minute globule, from which a fine fibril passes into the cell, and the fibrils, collectively forming a leash, are attached to its opposite end. (See Diagram 17.) It seems highly probable that the globule is a centrosome giving rise to two fibrils, one attached as described, the other passing up one side of the cilium, and fast to its apex. The result of this arrangement is that when the fibrils contract the cilium is bent over with a jerk to the side up which the fibril runs, and when they relax it slowly straightens itself. There is, therefore, no fundamental difference between this and the other mode of progression; both are dependent upon the centrosome.

Finally we have muscle cells. These are only found in a fairly complicated animal, since they are a product of the division of labour principle, and their sole business is movement. There are two varieties of muscle, but the principle is the same in both—a long thin cell, with fibrils traversing its length whose contraction causes the cell to shorten and thicken, thus reducing the distance between its two ends. At present the development of muscle and the way in which it ‘contracts,’ to use the word accepted in this case for describing a redistribution of bulk, are little understood, and there are accordingly many opinions; but I think careful study will eventually show that some modification of the centrosome, with its contractile fibrils, is responsible for the movement.

The two varieties are: the smooth, or involuntary, and the striped, or voluntary, muscle. Smooth muscle consists of spindle-shaped cells with one elongated nucleus. (See Diagram 18, Fig. 1.) It only contracts very slowly, and is not under control of the will; but it is very abundant in the body, since it effects practically all the movements of the alimentary canal and bloodvessels. Voluntary or striped muscle, so called from its appearance under the low power of a microscope, consists of long fibres, each containing many nuclei. (See Diagram 18, Fig. 2.) Its protoplasm is rich in hæmoglobin, and in it, under powerful microscopes, can be made out two kinds of fibrils: Rutherford’s fibrils, the complicated structure of which gives muscle its striped appearance; and Marshall’s fibrils, which are much finer and more difficult to see. The muscle of the heart, though not under control of the will, is striped; but it differs from ordinary striped muscle in being made up of small branched cells with only one nucleus.

The way in which the three elements of striped muscle contribute to a contraction is practically unknown, and the subject of much dispute. In fact, one could hardly wish for a better soil for theories, and some which grow in it are very wonderful indeed. We have reason for supposing that there are two contractile substances—one which gives a sharp twitch, the other a slow, hard pull; and on the whole there seems good reason to believe that Rutherford’s fibrils give the sudden movements, while Marshall’s give the more forcible ones; and that the ordinary protoplasm of the cell is restricted to the duty of nourishing the fibrils.

The muscle cells are modified from among those of the bud forming the middle layers of the embryo. (See Diagram 5.) Other cells of this bud form connective tissue, by, so to speak, spinning long fibres of the substance called collagen, which turns to gelatin when boiled. (See Diagram 20.) This connective tissue permeates the whole body, affording a firm foundation for the many layers of cells which form the skin and the single layer of digestive cells; supporting the other organs throughout, and keeping the different parts of the body in their places, in doing which, however, it is assisted by other fibres which are not collagenous, but elastic. It also forms tracts which become lymph and blood vessels.

In parts of the animal which require special support it forms solid rods, the collagen combining with calcium salts to form a clear, hard substance—cartilage. At one period in the development of an animal or animals we find the only solid support is cartilage, but cartilage is not sufficiently rigid for a very large beast, especially on land, so is only used for outlying parts, the main framework being bone.

Bone is formed very much as if Nature were rectifying a mistake. When a rod of cartilage is unequal to its work it is eaten hollow, and fresh connective-tissue cells immigrate and fill up the cavity, eventually laying down a fine network of cells in its place, the meshes of which are filled with inorganic calcium salts, chiefly phosphate of lime. Nature then benefits by experience, and the last bones to be formed are not preceded by any makeshift cartilage, but built up straight away in ordinary connective tissue.

This brings us back again to muscle, for the object of nearly all the voluntary muscle is to cause movement among the bones. For this purpose the muscle cells or fibres are arranged parallel to one another, and bound up together by connective tissue, the whole bundle being known as ‘a muscle.’ The two ends of a muscle are attached to two bones by connective tissue, which sometimes forms a short cord, or tendon. Then, when the muscle contracts, the two places of its attachment are pulled towards one another, and something has to move. But before saying more about the way in which the bones are jointed and muscles attached—in fact, what movements are possible in the human body—it would be as well here to describe the chief properties of muscle and the way in which they are studied.

The way in which voluntary muscle is studied is very simple. A frog is killed by thrusting a probe into the brain and down the spinal cord, and a muscle is then dissected out and attached to a piece of apparatus (see Diagram 21) in such a way that on its contracting it raises a lever, and draws a line on a moving surface. The rate at which the surface is moving is ascertained, so that the nature of the curve, which is a graphic record of the contraction, can be analyzed. (See Diagram 22.) For instance, when an electric shock is used to make the muscle contract, we find that a slight shock causes a small contraction, as shown by a low curve, while a stronger one, up to a certain point, causes an increase.

But having described how muscle is studied, it is only necessary to state a few facts concerning it; to discuss muscle, fully describing the experiments by which its more obscure properties have been elucidated, and the devices by which causes of error have been eliminated, would fill volumes.

Muscle is thrown into a state of contraction by an impulse reaching it from a nerve, but it contracts quite as readily if excited directly by a mechanical or electrical shock. A second shock causes a second contraction, or, if the muscle is still in a state of contraction owing to the first, causes it to contract still more. (See Diagram 23.) If a number of stimuli are applied to a muscle in such rapid succession that the effect of the preceding one has not passed off by the time the next arrives, it will contract as far as possible, and remain contracted—a state known as tetanus. (See Diagram 24.) A muscle is therefore kept in a state of contraction by a continuous nervous effort, not arranged and then left contracted.

Various conditions alter the character of a muscular response. With repeated stimuli at short intervals a muscle fatigues, and each contraction becomes smaller in extent and longer in duration. (See Diagrams 25 and 26.) If the muscle has to lift a load it has a certain check on its contraction, and its relaxation time is shortened. Temperature also affects muscular contraction, moderate increase causing a sharper, and moderate cooling a slower, rise and fall of the lever on stimulation. (See Diagram 27.) Lastly, we have drugs which exert an influence, but the only one of these which it is necessary to mention here is veratria, which makes the slowly contracting fibrils continue their activity after the quick ones have subsided. (See Diagram 28.)

Finally, there are the electrical changes in muscle. These, again, may be passed over briefly, since they are not easily understood or described. To put the facts in a nutshell, the part of a muscle which is in activity is negative to all other parts. Thus, if a muscle be dissected out and cut across, the activity at the seat of the injury, while it lasts, causes a current to pass through a galvanometer from uninjured parts to the wounded. (See Diagram 29.) Again, if a muscle be dissected out without injury, connected at two points with a galvanometer, and then stimulated at one end, as the wave of contraction passes along it, first one, then the other, contact becomes negative. (See Diagram 30.) S, Stimulating electrodes; N, contraction which marks the wave of excitation passing along the muscle; G, galvanometer which shows that the seat of activity (N) is negative to the rest of the muscle.

In passing, it may be mentioned that, as the heart is a muscle slung obliquely across the body, and waves of contraction are continually passing down its long axis, the whole body is affected by continual electrical changes. By very delicate instruments it can be demonstrated that with each beat the two hands alternately become electrically positive and negative to each other.

Whilst dealing with the electrical phenomena of muscle, it may be as well to state that nerve fibres, which are studied with very much the same apparatus, show the same electrical changes, the point of injury or of the greatest activity being negative to all the rest. Single cells are less easily investigated, but in glands it is possible to show that the same rule holds.

Undoubtedly the most curious fact about the generation of electricity by protoplasm is that, by a modification of muscle and nerve, which causes them to lose their ordinary properties, they are converted into a special organ for giving electric shocks. Armed with powerful batteries of this description, an otherwise rather helpless class of fish are enabled to defend themselves from their enemies, and deal unexpected death to their more agile prey.

Having now run over a few of the physical properties of protoplasm, we may pass on to a brief investigation of the movements we find in the body of man.

In describing the movements of the body, we shall have to treat them as several and distinct, as indeed they are; but the fact should not be lost sight of that they cannot really be isolated: one idea embraces the whole. Two kinds of movement may, however, be distinguished in the vital functions: movement of the actual cells, such as muscles; and movement of non-protoplasmic elements acted upon by the cells—e.g., lymph.

There is a parallel to this in the chemical side of life, where we find some phenomena peculiar to the living elements, and others, like digestion, going on in the living body, but outside the cells.

Taking the movements in the natural order—that is, proceeding from the simpler to the more complex—the first to be considered is undoubtedly that of the leucocytes, or general scavengers of the tissues. The body consists, so far as we have defined its anatomy, of three layers of cells, and its shape is that of a tube with hollow walls. (See Diagram 6.) Within the cavity of the body are various organs, such as the muscles, which are formed from the middle layer; and its space is largely reduced by glands, lungs, and other ramifications of the inner layer which forms the alimentary canal.

These organs hang more or less freely in the body cavity, slung to its walls by enveloping sheets of connective tissue, the whole being bathed in lymph. Now, in such an arrangement the products of wear and tear must accumulate. Cells here and there die for various reasons, and pieces of cells become detached even in adult animals. The interior of a bone is always being eaten away to decrease its weight, or in order that it may be replaced by fresh bone of a closer texture, and in young animals and embryos there are many structures which, useful for a time, have eventually to be removed; as an instance, we may quote the tadpole’s tail. In fact, if the tissues were left to themselves, the body would soon be choked with débris, and to avoid this it is supplied with an army of scavengers, the leucocytes.

The leucocytes are detached cells which owe their origin to the middle layer. In size they are, of course, very small, quite invisible to the naked eye. In appearance they resemble unicellular organisms of the amœba type, which we have had occasion to mention several times already (Essay II., Section II.; Essay III., Section I., Diagram 1). They are of several different varieties, some being larger and more active than others; but they all wander about in the lymph and blood like independent animals, creeping in and out between the cells of the organs, and devouring any foreign matter they come across. They sometimes multiply, like independent animals, by division, especially in the presence of inflammation, or when they have much work to do, and a rapid increase in their numbers is needed; and they have been induced to live, and feed, and multiply, outside the body (in which case they must be considered to have become independent organisms), thanks to the careful attentions of the experimenter.

Apart from their duties of devouring the inside layers of bones and clearing away dead tissue, they are supposed by some to assist in the absorption of food by creeping between the cells lining the alimentary canal, and, after throwing out arms to engulf particles of food, returning with their spoils into the body. Perhaps, however, the most interesting, or at any rate most romantic, of their many and important functions are what may be called their emergency duties. Frequently people, especially those who live in smoky towns, draw into their lungs particles of dust and soot, which if left adhering to the walls of the air cavities would cause dangerous irritation. As if by magic a leucocyte will discover the presence of such a nuisance, and, crawling between the cells forming the wall of the lung, in which, by the way, it is outside the body proper, will engulf it and carry it away with him. This exploit, however, pales beside the warfare which goes on in the body between leucocytes and invading bacteria. A bacterium thrives in the blood or lymph, since it finds itself in a warm alkaline fluid containing complex organic substances, by breaking down which it can easily obtain energy. Unfortunately, the products of such a process are frequently virulent poisons, the effect of which upon neighbouring cells produces the distressing symptoms which we associate with disease. No sooner, however, has the bacterium begun to generate poisons, than leucocytes, influenced by chemical attraction (Essay I.), swarm upon it. First come leucocytes of a small kind, full of zymogen granules, which crowd round the bacterium till they have covered it. After a time they creep away, leaving it dead. They are now in an exhausted condition, and no longer contain granules, having doubtless discharged them as a destructive ferment upon their enemy. Then a leucocyte of another kind moves to the attack, or, rather, to clear up the remains, for he is a large, non-granular, active fellow, and eats up the dead bacterium by the simple process of engulfing him whole. (See Diagram 31.)

A natural question arising out of the study of leucocytes is, What becomes of them? Particles of soot and similar refuse can hardly be considered nutritious, or even digestible, food, and one is rather drawn to the conclusion that the leucocyte performs its functions for the good of the body at large, not of itself, and that when its work is done it must die. Many leucocytes, probably, loaded with unconsidered and undesirable trifles, cast themselves into the alimentary canal, and are got rid of with the useless portions of the food; but they do not always have the luck or energy to get to a natural outlet. An unpleasantly familiar phenomenon is the boil. Here we have some irritating substance under the skin setting up inflammation, and leucocytes swarm up to remove the cause of the trouble. Before, however, this is done, many have perished in the fray, and they have collected in numbers to the formation of what is commonly known as pus, or matter. Their dispersal into the body is now neither easy nor desirable, and the surgeon usually lets them escape from the surface by a touch of the lancet.

Such, then, is very briefly the story of the leucocyte, neglecting such problems as the differences between those found in the blood, called white corpuscles to distinguish them from the red corpuscles, with which they have no sort of connection; those found in the lymph, called lymphocytes to distinguish them from those found in the blood; those caught in the act of devouring bone, called osteoclasts; and those found with bacteria inside them, therefore known as phagocytes; and without speculating on how long an individual lives, and whether the different varieties differ in origin or are merely at progressive stages of development. The study of leucocytes is one of the most fascinating in physiology, but we have many other things calling for our attention, and we have said enough about the part they play in the life of the body to justify our passing on to consider another essential movement.

Next in natural order for consideration come the movements of the alimentary canal.

So far we have considered this structure as a chemical laboratory, a tube consisting of a single layer of cells which secrete ferments into the lumen, where digestion takes place, and then absorb the products, and we have not yet accounted for the food travelling along the tube, without which its functions, as described in the earlier part of the book, could not be performed. That the passage of the food is not due to gravitation is obvious from the many directions of the tube’s coils—not to quote the old instance of a horse drinking, in which case the liquid first travels upwards. One must therefore conclude in favour of some muscular method of propulsion.

We have so far described the alimentary canal as a single layer of cells, but it must be obvious that these soft secreting portions of the tube are not capable of vigorous movement. The canal proper is surrounded by a tough sheath of connective tissue which prevents its being overdistended or ruptured, and, by means of a layer—or, rather, two layers—of non-striped muscle which it contains, produces the movements which result in the passage of its contents along the tube. These two layers lie well to the outside of the connective-tissue sheath. The fibres of the inner layer are arranged circularly, so as to form rings round the tube; those of the outer have a longitudinal direction, running, therefore, parallel with its long axis. When the former contract, the diameter of the tube is reduced, while contraction of the latter has the effect of enlarging it. (See Diagram 32.)

The movements of the intestine are what is known as peristaltic. Contraction of the muscle fibres is not simultaneous in all parts, but passes in waves along it. Just in front of the food the longitudinal fibres contract, and thus offer less resistance, while just behind the circular fibres reduce the size of the tube, and so get up a pressure. The result of a number of successive waves of contraction passing down the alimentary canal is that the food is propelled along it.

The arrangement of the muscle varies in places to suit special needs. Where the tube suddenly enlarges to form the stomach, and where the stomach suddenly narrows to the intestine, there are two strong rings of muscle, whose constricting influence converts the enlargement into a closed chamber during gastric digestion; while the coats which actually clothe it here run obliquely, and their activity causes the contents to be slowly churned about inside.

Thus it will be seen that it is not only the voluntary muscles which give the alimentary system its opportunities; without these unobtrusive non-striped cells we should toil for our bread and swallow it in vain.

Our next step, after having surveyed the principle of movement by which the chemical necessities of the body are exposed to its absorbing surface, must be to see how the fluid which transports them is made to pass along the tubes containing it. We have already had occasion to describe how these blood and lymph vessels ramify through all the organs, when we were dealing with the chemical influence of the blood and lymph.

The tubes through which the lymph is brought back to the blood-stream have thin walls, and no muscle of their own. They are subjected, however, to a constantly varying pressure by the movements of the limbs and trunk, and as, owing to valves inside them, the lymph can only escape in one direction, there is a constant flow towards the junction with the bloodvessels.

The bloodvessels are quite different. A far more certain and expeditious current is necessary—hence the steady circulation through a system of closed tubes.

In order to understand this passage of the blood, it is necessary to keep in mind the great principle with which hydrostatics supplies us, viz., that a liquid always flows from a region of high to a region of lower pressure. The problem of the vascular system is, therefore: How can the pressure within a ring of tube be so arranged as to maintain a regular flow always in the same direction?

Let us begin with the structure of the system. The tube through which the blood first passes on leaving the heart is composed of four distinct and essential elements: A lining of endothelial cells, which we need not discuss at length; a main substance of tough white fibrous connective tissue; elastic fibres and muscle fibres, the two last arranged in the substance of the connective tissue. All these parts are present in the main arteries which leave the heart, but in the fine meshwork of capillaries to which the arteries give rise by repeated branchings there is nothing left of the outer coats, only the lining of endothelial cells separating the blood from the organ traversed. In the veins which these capillaries unite to form, the connective-tissue sheath reappears, and also some muscle; but the elastic coat is quite absent. The heart is really a double coil of the tube (see Diagram 12), in which the muscular coat is predominant, and is divided into four chambers by the valves, which insure the blood flowing in the right direction when it contracts. (See Diagram 33.)

The way in which these structures work is as follows: Two of the chambers of the heart (the auricles) receive blood from the veins, and when full suddenly contract, driving their contents into the other two chambers (the ventricles). The blood does not run back into the veins, although the pressure in them is very low and there are no valves to prevent it, because there is still less pressure in the ventricles, and also because the veins enter the auricles obliquely, and the tendency of the increasing pressure is to close their orifices. Having discharged the blood into the ventricles, the auricles relax, and the pressure within being a minus quantity, they are speedily filled with blood from the veins, blood not being able to return after entering the ventricles, as valves close automatically to prevent it.

Stimulated by the blood distending them, the ventricles then contract simultaneously like the auricles, only with much greater force: for the right ventricle has to drive the blood all through the vessels pervading the lungs back to the left auricle; whilst the left ventricle, which is proportionately stronger than the right, has to send its contents to the furthest extremities of the body. They then relax, in order that conditions of their internal pressure may favour another inflow from the auricles, return of blood from the arteries being, as in the preceding case, prevented by valves.

The pressure in the arteries during life is always fairly high; indeed, the ventricles have to get up a considerable force before the valves leading from them will open. The result of this is not only that the blood is driven along them with a rush, but also that they are slightly distended at each beat; and so, owing to the elasticity of their walls, the blood continues to flow forwards even between the beats of the heart. The rest of the journey is quite simple; the pressure in the capillaries is lower than in the arteries, and the pressure in the veins lower than in the capillaries, and lower in the veins, too, as they approach the heart, till, where they join the auricle, it is actually minus, and the blood has no other course open to it but to return to the auricle. It looks as though accidents might happen in the veins owing to there being so low a pressure there to direct the current, but this is prevented by the presence of valves at intervals, to stop any return.

The rate at which the blood travels is another point which has an important bearing on the nutrition. It does its work—i.e., gives out nutriment and picks up refuse—whilst flowing through the capillaries; so here one finds that it moves slowly. On the other hand, the sooner it reaches them the better, so it races fast through the arteries. Finally, its return to the heart need not be delayed, so it is quickened up again through the veins. The principle by which this variation in the rate of flow is obtained is simple and inevitable. If a tube through which liquid is flowing is not the same size all the way along, the liquid will be found to flow faster in the narrow parts than in the wider ones. Now, in branching, the arteries do not keep becoming smaller in regular proportion, and the result is that the capillaries have collectively a diameter five hundred times larger than the aorta; hence the blood flows through them only one-five-hundredth of the pace at which it leaves the heart. But in uniting again to form the veins their cross-section is reduced once more, so that that of the large veins near the heart is only two and a half times larger than that of the aorta, and hence a flow only two and a half times slower results.

The pace of the blood-stream must depend, obviously, on the pressure of the blood in the arteries. This pressure is altered either by changing the rapidity of the heart-beat or the diameter of the arteries, which are capable of considerable variation owing to their muscular coat. The regulation of the blood-pressure is managed by the nervous system, so does not belong here, and we may leave it after mentioning one or two facts. High pressure is due to a large quantity of blood being in the arteries, and this may be due either to the rapidity with which it is injected by the heart or to the reduced capacity of the bloodvessels themselves. High pressure, due to the latter cause, throws a great strain upon the heart, owing to the hard work it has in pumping blood into the arteries; with a low pressure the heart beats feebly, having less resistance to overcome.

Blood-pressure can be raised by stimulating the muscular coat and reducing the capacity of the bloodvessels, and lowered by causing the heart to beat more slowly or by removing blood from the body. This latter operation was a favourite way with doctors of the old school; but as our knowledge of physiology, and with it our control over the vital functions, increases, such crude and heroic remedies are able to be replaced by others which are less dangerous.

Comparisons are rightly regarded as objectionable, so it would hardly be safe to say that the group of movements whose primary object is filling the lungs, and which we must study next, is the most important in the body, especially when we have just been speaking of the circulation, which, however, would be of but little use if the blood could not be oxidized; but we can at least say that its importance cannot be overrated, so far-reaching are its effects.

The lungs are, as we have described them above, a pair of delicate membranous sacs connected by a tube, the trachea, with the alimentary canal, from which they originally budded out. They are subdivided, though how we need not describe in detail, into a vast number of small compartments, so as to give the maximum surface in the space accorded them, and the whole somewhat resembles a cluster of grapes, the stalks being the branches of the trachea. The membranous parts are pervaded by an elastic network, enveloping the compartments in such a way that it would reduce them permanently to the resemblance of a bunch of raisins rather than grapes, were it not that they are enclosed in an airtight box—the thorax—from the walls of which they cannot shrink without causing a vacuum. Owing, however, to the latter arrangement and the trachea being open to the external world, they are always more or less distended with air.

The thorax, which they thus must always exactly fill, is a conical-shaped box, its walls being the ribs, and its floor a sheet of muscle known as the diaphragm. It contains, besides the lungs, only the heart and large bloodvessels. The problem, therefore, of drawing air into the lungs and (after the gaseous interchange described in Essay II., Section IV., has taken place) of expelling it again, becomes solely a matter of increasing and decreasing the capacity of the thorax. (See Diagram 34.) This can be done in two ways: the diameter through the ribs can be increased, or the diaphragm can be pulled down, increasing its depth. Actually, both these methods come into play together. Diagram 35 will probably give a better idea of how this is done than could easily be conveyed by a verbal description. An attempt is here made to show the action of the ribs and the diaphragm—first, of each separately, then of the two combined. The elasticity of the lungs themselves is sufficient to drive out the tidal air if the diaphragm and the muscles of the ribs are relaxed, though in hard breathing a muscular movement may depress the ribs and a contraction of the abdominal muscles force up the diaphragm.

But though the primary object of raising the ribs and depressing the diaphragm may be to fill the lungs, its secondary influence upon the trunk as a whole is hardly less important. The effect upon the circulation is profound. The compartments of the lungs are enveloped in innumerable capillary bloodvessels, and, as these lie around and between them in the cavity of the thorax, they must, when breath is drawn in, be subjected to a negative pressure before the lung itself, and be the first to experience a positive pressure when the air is expelled. Here, again, a diagram is the best explanation. (See Diagram 36.)

The pulmonary vessels, moreover, are not the only ones influenced. The reader who attentively examined Diagram 13 must have been struck by the peculiarities of the circulation through the spleen, intestine and liver, and the obstacles which this repeated breaking up into fine vessels must offer to the flow of blood, as described in Section V. of this essay.

The liver forms the crux of the situation. (See Diagram 37.) A vein carrying blood from the intestine and spleen is broken up into fine capillaries to pass through that organ, and the pressure in this vein is extremely low. How is a sufficiently rapid flow of blood to be maintained? The answer to this riddle is best given by Diagram 38, which shows how, by the contraction of the diaphragm at each breath, the large veins entering the heart are subjected to a negative pressure which draws blood out of the liver, while, simultaneously, that organ is squeezed and the blood it contains forced out. Obviously this natural pump influences not only the flow of blood, but also that of the lymph, and what was said about the hepatic vessels also holds good for the thoracic duct, up which the lymph, rich with fat absorbed from the intestine, passes to be emptied into the large veins near the heart. So, though vigour in the action of the diaphragm is more favourable to health than necessary to life, deep breathing is an essential factor in the well-being of the body.

All the movements as yet described are absolutely necessary to the continuation of life; they are, moreover, independent of the efforts of the will. But there remains yet another kind of movement without which the body, left to itself, would die. This is the movement of the limbs—organs by which the body is able to move from one place to another, to capture its food and convey it, viâ the mouth, to its stomach—in a word, to satisfy its chemical and physical needs.

To understand how the limbs work requires a knowledge of their anatomy, for which we have not time or space here; but the principle throughout is that of a system of levers, the bones, worked by the voluntary muscles. Here, as before, a diagram will probably be found to convey more than could ever be expressed in words. (See Diagram 39.)

The diagram represents very roughly, but it is hoped very plainly, the main principle of the elbow-joint; but for an exact knowledge of the mechanism of the joint, and the comparative strain upon, and therefore strength of, each muscle, the reader must consult some work on anatomy. He will there find, if he goes on to read the description of the hand, what a wonderful precision, complexity, and amount of movement can be obtained by variations of this simple device.

Here, however, we must leave the study of the manner and object of the bodily movements, and proceed to investigate the far more intricate question of how they originate and are controlled.

ESSAY IV. THE NERVOUS SYSTEM. — I. — II. — III. — IV.

Now comes the final problem. Protoplasm forms a structure always changing, always making good its waste by chemical action upon raw material, always capturing raw material or in search of it, always, when it exists in large quantities, and the labour is therefore divided between many cells, economically apportioning the work and the spoils. How is it that all the actions, chemical as well as physical, of a vast number of cells composing a large body are, no matter how complicated, always harmonious, and always with purpose directed to the advantage of the whole animal?

In the first essay in this book we discussed the phenomenon of life, and described briefly the chemical and physical peculiarities of protoplasm. These in the two succeeding essays we have gone into more fully; but there is one characteristic of that interesting substance which yet remains for us to examine in specialized cells, viz., its extreme readiness to respond to changes in its environment.

In Essay I. we saw that chemical agents, light, heat, electricity, etc.—had a definite effect upon protoplasm, and that, though they might influence different kinds in different ways, the effect was nevertheless invariable; in a word, the response of protoplasm to circumstances is automatic. But the most remarkable thing about this is that the response is not confined to the protoplasm actually affected, but is transmitted to that nearest to the part stimulated, and again passed on to that beyond, so that a wave of excitation passes through the whole mass, not stopping till it has reached the extreme confines of the cell. It may even pass beyond these and set up activity in neighbouring cells. The power of conductivity once grasped, it may easily be seen that certain cells, by specializing in this direction and adapting their shape to the needs of the body, might by throwing out long threads to reach distant parts set up an organic system of telegraphy.

The organs developed for the control of the body owe their origin to the outer layer. (See Diagram 5.) This was only to be expected. In the second essay, in which we treated of the chemistry of the body, we, of course, touched upon all three layers from which the body is built up; but the one which chiefly occupied our attention was the innermost layer, which is so admirably arranged as a chemical laboratory. In the third essay we dealt chiefly with the middle layer, which both by its position and its bulk might have been guessed to be the foundation of most of the motor organs. Now that we have come to the organs of perception and transmission of impressions, it is only natural to expect that they should be specialized from the cells already in contact with the external world, and which, since they form the envelope of the animal, must allow all such stimuli as reach the subjacent motor layer to pass through them.

Hitherto we have not dealt at great length with the development of the organs whose functions we have been describing, either from the point of view of the embryologist or the evolutionist. Nor have we spent much time upon their gross anatomy. With the nervous system we must proceed rather differently; for to understand how its higher functions can be performed they must be traced from their origin step by step, while their complexity is largely vested in the structure of special organs.

The way in which the nervous system was evolved is shown in Diagram 5. Originally, no doubt, the cells of the outer layer, when the latter was in its simplest form—that is to say, only one cell thick, not several, as it is in our skin—would, when influenced in any way directly call forth the activity of the motor cells lying beneath them. (See Diagram 40, Fig. 1.) In Fig. 2, however, we see one cell of the outer layer becoming specialized. It has thrown out a process above the surface of the skin the more readily to catch impressions, and has sent another down into the body the better to distribute them. Diagram 41, Fig. 1 shows the nerve cell at a further stage. The principle is the same, but the cell is removed to a safer place. In Fig. 2 it is not exposed to the outside world at all, but by receiving its impulses second-hand from several cells the same work is done with greater economy and uniformity. Some of the special sense organs are still developed in this way.

Once the nerve cell is developed and safely shifted into the interior of the body, it is clothed with a protecting feltwork of connective tissue, and the nerve fibres are also surrounded by connective-tissue cells which secrete around them the fatty substance which makes nerves look white.

Such is the nerve cell or intermediary between the world and the muscles; but thence to harmonious movement in a body with complex organs capable of varied actions is a long step. To obtain precision and uniformity throughout the body, all the impressions received must be collected and balanced, and stimuli, the correct outcome of this balancing, must be transmitted to the muscles, glands, etc., whose activity circumstances require. The way in which cells of the outer layer become enclosed to form a central nervous system is shown in Diagram 5; but its development will be better seen in the figures of Diagram 42.

This diagram shows how certain cells of the outer layer are budded off and transferred to a safe place within the body. In this position the cells are further developed, throwing out one long fibre, which goes to some distant organ of the body, and short fibres, which, though they do not join those of other cells and become continuous, closely interlace and put them into communication. They are also separated from one another by connective tissue, which supports them, holding them suspended with only their fibres approaching one another (Diagram 43). Diagram 44 shows how the bone which replaces the supporting rod (see Diagram 6) throws an arch round the feltwork of connective tissue in which the nerve cells are suspended, giving them still further protection.

It will be noticed in the figures of Diagram 42, which is fuller than Diagram 5, that there are three of these buds—one central and two lateral. The central one becomes a tube running the whole length of the animal, while the lateral buds form solid clusters or ganglia, arranged in pairs at intervals beside it (see Diagram 45). Fibres from these ganglia go to the skin, and bring to the nerve cells information from the outside world, which they duly pass on to the cells of the central column. The cells of the central column, when set in motion by the ganglion cells, send out impulses to the muscles, whose contraction is necessary to perform the movement which circumstances indicate. A movement brought about in this way is called reflex.

The reflex movements are, however, not quite the simplest. For instance, the food is moved along the alimentary canal by the contraction of two sets of muscle fibres—an outer longitudinal coat and an inner circular one. Between these two coats are some nerve cells, which are thrown into activity by the presence of food and the iron compounds of the bile secreted by the liver in the tube. These sympathetic cells do not send their impulses to any centre for examination, but at once stimulate the muscle fibres between which they lie, thereby producing the peristaltic movements we have already described. Yet it should be remembered that, though these cells act independently of the central nervous system, they are under its control, and can, if need be, have their action modified for the benefit of the body as a whole.

For convenience’ sake, we had better here specify the chief kinds of nervous action. First there is what we may call the immediate nerve action, such as that we have just been describing; secondly there is reflex action, the centres for which are in the spinal cord and the base of the brain; and thirdly there is voluntary movement, which arises out of the interaction of centres in the hemisphere of the brain, where the most complex machinery of all is kept.

Of the first kind we need say no more. The instance of peristaltic movement illustrates it sufficiently; so we can at once begin a more careful examination of reflex action.

The simplest instance of reflex action may be taken from the schoolroom. If a boy suddenly sticks a pin into an unsuspecting schoolfellow, the latter invariably starts, and frequently lets fall an exclamation also. In this case the presence of an injurious agency is reported to the nearest motor centre, which is in the spinal cord, and this automatically convulses the body, jerking the limb out of danger.

This is reflex movement; the nerve fibre, which conveys an intimation of the injurious influence, is a prolongation, or really two prolongations, of a spinal ganglion cell. (See Diagram 46.) The near end of this fibre, which enters the cord, has several branches. Some run a little way up the cord, and some a little way down, so as to communicate with several motor cells; but one branch runs right up the cord, and sends the message on to the brain. Our outraged schoolboy starts a fraction of a second before he is conscious of the pain of being pricked, and this first response is involuntary and unvarying; the sensation, however, is reported to his brain, and the workings of that wonderful organ are less easy to predict. It leads to his taking stock of the aggressor, on the strength of which he decides whether it is safe to attempt a reprisal, and, if so, in what form it will be most effective and least likely to attract the master’s attention. This knotty point settled, the motor cells of the brain send down messages to the motor cells of different parts of the spinal cord, and these in turn set the necessary muscles in motion for delivering a surreptitious kick or aiming a splash of ink, as the case may be. This is voluntary movement.

The difference between reflex and voluntary movement is, as may be seen from the above instances, very much a matter of degree; but we had better leave a comparison between them, and any discussion as to the extent to which the manifestations of consciousness are automatic, until we have finished describing reflex movement, and set forth the little we know about voluntary movement.

Time and space forbid a complete list of reflex movements. The following are, however, a few typical examples of how the body is automatically made to perform such acts as are necessary, and of how such as do not require deliberation are brought about without taxing the intellect.

A reflex action which is unpleasantly familiar is the cough, also the somewhat similar phenomenon of the sneeze. In this case, a foreign body which obstructs the windpipe, or causes irritation to the membrane lining the nose, is, on being reported at the spinal cord, incontinently blown out by an explosive blast of air from the lungs.

An organ which is very important, and at the same time very sensitive—viz., the eye—has many protective reflexes. The external surface of the eye is covered by a very delicate membrane, which must be kept moist and scrupulously clean. Whenever this membrane gets in the least dry, or any dust falls on it, the eyelids are closed for a moment, thereby bathing it with the secretion of the tear glands. Few people are aware, I think, that they blink their eyes on an average twice every minute. The eyes are also closed quite involuntarily by a reflex when any danger threatens them—for instance, a sudden dazzling light, a strong wind, or a blow aimed at the face; and if any foreign substance—say a fly—does get into one of them, the secretion of the tear glands is enormously increased to wash it out.

The size of the pupil, again, is quite involuntarily, i.e., reflexly, altered in proportion to the strength of the light.

Reflex actions are, however, by no means only protective. The act of swallowing is reflex. So is the secretion of the digestive glands when the lining membranes of the stomach are stimulated by the presence of food. The very act of standing depends on the reflex principle, the tendency of the body to collapse and fall being unconsciously perceived and corrected by the spinal cord. Walking is also a reflex action. It may be objected that we think about walking, and do so with intention; but it is of common experience that we can walk along ‘thinking of something else,’ and the way in which an intellectual though absent-minded man will run into people, charge lamp-posts, trip over steps, and tread upon dogs, is sufficient to absolve the organ of thought and intention from any share in the performance.

The blood-pressure is also automatically regulated, both the diameter of the bloodvessels and the frequency of the heart-beat being under reflex control; and we may, as a final instance of reflex action, describe one of Nature’s most perfect and merciful contrivances—fainting. Suppose a man receives a severe wound—say, has his hand struck off by a sword—the shock to his system causes an immediate dilatation of the large bloodvessels of the abdomen; this results in a great fall of blood-pressure, and the heart, finding that it has much less resistance to overcome, slackens its beats so that soon the flow of blood is very slow indeed. Hence, it has time to clot over the wound, and the man does not bleed to death. Incidentally, the feeble current of blood is insufficient to keep the most delicate organ of the body, the brain, in its normal state of activity, and the man is relieved from his pain by unconsciousness, which passes off when the heart again quickens its beat. It is perhaps needless to remark that fainting fits are not always and only caused by flesh wounds; they may be due to weakness or other causes.

Now, if we consider the instances quoted above, we are able to deduce a few general principles from them. In the first place, it may be noticed that reflex action compels us to perform the movements necessary to our existence whether we like it or no. It is not for us to decide whether we will breathe or not. We must. The strongest-willed man who ever lived, no matter how much a philosopher, could not commit suicide by holding his breath, as Cato boasted he could. Directly he lost consciousness, supposing he managed to hold out till then, the tainted blood bathing the respiratory centre would awake it to activity, and he would start breathing afresh. Again, it is noticeable that many of these actions could not possibly be performed by a voluntary effort. We can, to a certain extent, regulate the depth and frequency of our breathing, and we can blink our eyes voluntarily; but an average man would be quite at a loss what to do if asked to make the pupil of his eye dilate and contract, the glands of his stomach secrete, or his heart alter its rhythm.

It is a familiar fact that some reflex actions can be altered by an effort of the will; in other words, an impulse from a brain cell will prevent a nerve cell in the spinal cord from discharging. But it is an equally familiar fact that with continuous stimulation the impulses accumulate and ultimately overcome this resistance. Most people have at some time or other striven to resist the inclination to cough, consequent upon a tickling sensation in the throat, and know that there comes a time when they can restrain themselves no longer. This is because the accumulated stimuli from the throat, having reached a greater strength than the prohibitive impulse from the brain, succeed in compelling the cells in the cord to discharge.

Lastly, reflexes can be learnt. When a young child first endeavours to stand upright, the sensation of falling is doubtless conveyed to the brain, and thought taken of how the erect position can be maintained. But it is not until after many experiments and failures that the brain-cells can send messages to the right cells in the cord, and these set the necessary muscles in motion. Experience teaches what must be done, and constant practice eventually enables the spinal cord to act for itself without referring for orders to the brain. It is on the same principle that we learn to ride the bicycle. At first we have to devote our whole attention to keeping our balance, but in a short time we find we are doing it with our mind free to contemplate the scenery.

What can be done by reflex action can only be appreciated by observing an animal from which the brain has been removed. A frog which has been treated in this way—the operation, it should be said, if performed under an anæsthetic can cause no pain, either at the moment or afterwards—will live for weeks—in fact, almost indefinitely—if proper precautions be taken. But it is an automaton pure and simple. Unless touched it sits absolutely still. If touched it hops once or twice straight ahead regardless of obstacles. If placed in water it swims, equally regardless of obstacles. If turned on its back it immediately resumes its normal position. If small chips of wood are placed on its back it kicks them off. If the table on which it is sitting be tilted it will crawl up the incline until it reaches a level. But it will starve in the midst of plenty, having lost all power of thought, memory and perception. If diligently fed by hand a frog, a fish, or a bird will live for a long time without any brain, since their repertoire of movements is small and mostly reflex, and their occasions for deliberated action comparatively few. But the higher we get in the scale of life the more the brain takes over the duties of the cord, the less automatic become the greater number of the actions, and hence the more open does the animal’s conduct lie to moral criticism.

We have now seen how protoplasm exists in a large body, sharing the work of living amongst specialized cells, and how it responds as a whole to the influences exerted upon it by its surroundings. The next thing to consider is how it is situated with regard to matter which does not form part of its own body; how protected from, and how put into communication with, the rest of the universe.

With regard to the former, we have seen that in the single cells, constituting unicellular organisms, there is always a bounding membrane of denser texture than the rest of the protoplasm. As the cell develops its capabilities, we have a shell or case of non-living matter secreted around it, with apertures for communication with the outside world, and increasingly effective protection is provided as protoplasm, whether in the single cell or the body, leaves the water, and has to face the inclemencies of terrestrial life.

In the schematic embryo (Diagram 6) and other diagrams contained in this volume, the skin has so far been represented as consisting of a single layer of living cells; but we must now admit that the skin of man is quite different. Such a covering would be no protection from heat, cold, or irritating chemicals, while, in order to prevent its drying up, it would have to be kept moist with slime, and we should look very like frogs. In order that an adequate defence may be provided for the body, this layer of cells divides tangentially, forming two layers. The inner of these two then divides tangentially again, and a second layer is interposed between the innermost and that first formed. The skin now consists of three layers, and so the process is repeated until it is several layers thick. (See Diagram 48.) It is the innermost and best-nourished layer which keeps dividing; the other layers, as they get pushed outwards, are only reached by a little lymph which filters between the cells, and are eventually starved even of that. As they get pushed away from the dividing layer, however, they set to work to surround themselves with a horny wall, which thickens and thickens, until eventually there is hardly any cell left. (See Diagram 49.) Finally the cells die and the horny envelopes form a dead cuticle, protecting the living layers beneath, and are ultimately sloughed off when their successors are ready to replace them.

Not even a horny layer of dead cells is, however, always sufficient protection, and the growing layer has sometimes to supplement it by hair or feathers. How hair is developed is shown in the accompanying diagram (50). The growing layer sends a strand straight downwards into the connective tissue, which forms the basement of the skin. The cells in the middle of this strand, which behaves like ordinary skin, are the least well nourished, and accordingly die and leave a tube. This tube, if no further development took place, might become a sweat gland; but if it is to give rise to a hair it becomes cup-shaped at the base, enclosing a small loop of bloodvessel. The cells just above the capillary, being better nourished than the rest, grow more rapidly than their neighbours, and the result is that a column of cells which we know as a hair pushes its way up through the tube. (See Diagram 50.)

This outer layer comes everywhere between the main bulk of the body and the outer world. Hair and sweat glands do not by any means represent its only modifications. Teeth are formed from it in somewhat the same manner as hair, while we have already seen that it gives rise to the whole nervous system.

The next thing which we have to consider is how knowledge of the external world reaches the central nervous system. Sensations of touch, temperature, and pain are fairly easy to understand, since the nerves which convey such impressions have numerous endings in the skin. End organs of nerves in the joints and muscles doubtless enable the animal to perceive and estimate strain and resistance in moving or lifting things. But the power of perceiving the chemical peculiarities of things; light, involving the formation of visual images, which we call seeing; sound; and position and equilibrium, it is not possible for the whole surface of the body to possess. The principle of division of labour is extended to the task of perception as well as to that of motion; and cells, with their property of responding to light, vibration, chemical stimulation, etc., are grouped together to form special organs, connected with the central nervous system by special nerves.

Perhaps the most important factor which can influence protoplasm is the chemical nature of its surroundings; and in the first essay, on the general nature of protoplasm, we touched upon the way in which it is drawn towards some substances, and repelled by others.

In the body there are two sets of cells deputed to act for the rest in this particular. One set is situated in the membrane lining the nose, over which the air we breathe passes; and these cells examine our gaseous surroundings, and warn us, by what we term ‘smell,’ whether the atmosphere is fit for us or we had better seek a purer. The other set is for the examination of liquids. Against these we are protected by our skin, and, as we do not absorb anything through it, it is devoid of the power of examining the things it touches. But with our food it is different; we must have the power of testing that. Accordingly, there are Customs officers in our mouth in the form of little groups of cells, which report upon the liquids and solids moistened by saliva, and enable the animal to reject pernicious imports. Thus, the stimulation of a small portion of the protoplasm composing a body is transmitted over the whole, and is able to awake in it the necessary response.

So much for the chemical sense organs; they are comparatively simple. But between a single cell, which always makes towards or always hurries out of a ray of light passing through the water in which it swims, and an animal with eyes capable of recognising the colour, shape, size, and distance of objects in space, there really does seem to be a wide gulf. It is not, however, too wide to be bridged.

After the single-cell stage has been passed, and we have beasts consisting of an inner layer of cells which is digestive in function, and an outer layer which is protective, motor, and sensory, the power of perceiving light is doubtless vested in the outer layer. When we get beasts consisting of three layers progressing along the straight path of development which leads to man, we find the outer layer becoming too opaque for this purpose, and the torch is handed on to the sensory tube derived from it. (See Diagram 5.) As more and more protection is required, the skin thickens, and the neural tube comes to lie deeper, as in Diagram 51. In order not to lose the light altogether, it has to throw out buds, which concentrate in themselves the peculiar faculty of perceiving it, and at the same time little pits are formed in the skin just over them to help the light to reach them. (See Diagram 52.) In Diagram 53 both the nervous elements and the integumentary are developing their possibilities; and in Diagram 54 a large surface has been prepared for the reception of light, and a lens formed to focus the rays upon it. Diagrams 55 and 56 give the concluding stages in the development of the eye: the formation of the cornea and its protecting eyelids. The two cavities are filled with clear liquids, and the whole eyeball supported by connective tissue.

So fascinating is everything connected with the eye that the temptation to describe it in detail is great; but in a book of rough outlines, and in consideration of the many important matters yet awaiting their turn, we must confine ourselves to briefly mentioning a few of the more important points concerning it. The light is focussed by the lens upon the nervous curtain at the back, and produces there a picture, as in the photographic camera. Thus we perceive the shape of objects. The different rays of the spectrum affect different elements in this curtain or retina, whereby we get sensations of colour. Finally, the clearness of the picture, its size, the degree of convergence of the two eyes, and the effort of focussing—for the curvature of the surface of the lens can be altered—enable us to estimate the size and distance of an object. And now, though it would take volumes to do justice to the physiology of vision, we must pass on to deal equally briefly with the functions of that no less important organ, the ear.

The essential part of the ear is a membranous bag, formed by the pouching in of the outer layer of cells—as shown in Figs. 1, 2, and 3 of Diagram 57—which comes to lie in a bony chamber beneath the skull, and assumes the somewhat complicated shape depicted in Fig. 4. We have not time, nor is it for our purpose necessary, to trace all the steps in the development of the ear, either external or internal, nor need we spend much time upon its structure, beyond indicating its position. But its position, which is shown in Diagram 58, must be grasped in order to understand how it is influenced by sound.

It will be seen that the membranous bag, which is fitly termed the labyrinth, is situated in a bony cavity which fits so closely as to be termed the bony labyrinth (C). The membranous labyrinth is filled with a liquid, called endolymph, and the bony labyrinth (C) is also filled with a liquid, called perilymph, in which the membranous bag swims. All this is called the inner ear. The inner ear communicates with a second cavity—the middle ear (B)—by two apertures in the bony wall, which are closed by membranes. The middle ear is full, not of liquid, but of air, and is separated from the external ear, the cavity marked A, which is open to the external world, by another membrane called the tympanum, or drum, of the ear. The middle ear is connected by a tube with the throat, so that the pressure of the air on both sides of the drum may be the same.

Now, the object of this arrangement is that the ear may be able to fulfil one of its principal duties, namely, the perception of sound. Sound, as the reader is doubtless aware, is transmitted through the air as waves of condensation and rarefaction, due to the swinging backwards and forwards of its particles; it resembles the passing on of a bump along a line of trucks on the railway when the engine runs up against the end one preparatory to coupling. The magnitude of this oscillation we perceive as the loudness, the frequency as the pitch of a note. Now, when the waves of sound strike against the drum of the ear, they cause it to vibrate backwards and forwards also. Supposing there was no middle ear, and the sound waves beat directly upon the membranous windows of the inner ear, these could not be made to vibrate, as there is liquid behind them, and liquids are incompressible; so, in order that the movements of the drum may be transmitted to the liquids of the inner ear, they are carried across the middle ear by a chain of small bones, by which their extent is curtailed, but their force increased, and brought to bear upon one only of the two openings. The consequence of this is that the membrane closing it is able to vibrate and pass on the vibrations to the liquid within, since when it is pushed in, the membrane covering the other hole is pushed out.

Exactly how the different parts of the membranous labyrinth contribute to our perception of sound we do not quite know. It appears as though the difference of pressure in saccule and utricle originally conveyed to the brain a sensation of noise without any idea of quality, while the cochlea was developed later to analyze sounds and give information as to pitch and tone. Whether the rest of the labyrinth has any longer a part to play in the perception of sound, we cannot say with certainty; but it seems pretty certain that the cochlea is the organ for receiving musical impressions. Here, again, though, we are at a loss, for we do not know with certainty how the cochlea acts. In shape it is a long tube, and in the head is coiled spirally—like a snail’s shell to look at. Along its whole length is a ridge of cells with short hairs projecting from their inner surface into the liquid it contains; and to the cells along this ridge a branch of the auditory nerve is distributed. But as to whether one of the cells along this keyboard responds to each of the notes we can distinguish, or whether they are affected as a whole, physiologists are not yet agreed.

At least one other important duty the ear performs; it tells us in what position we are, and how our whole head moves or is moved. On the top of the saccule, in Diagram 57, Fig. 4, there are shown three little loops which are called the semicircular canals. They are shown again more clearly by themselves in Diagram 59.

Fig. 1 shows their position with regard to each other. It will be seen that two of them are vertical, with their loops forming a right angle with one another, and that the other is horizontal—in fact, that they lie in the three planes of space. Fig. 2 shows the structure of one of them; it has a swelling at one end (a), and a knob projecting into it where the nerve joins it (b). In Fig. 3 is shown a section through this knob, which gives the key to the use of these structures. A little head of cells projects from the wall of the canal into its lumen, and from these cells hairs bristle out into a dome-like covering of jelly, weighted, to prevent its moving too easily, with small particles of lime. Now, if you take up a round vessel full of liquid—say a bowl of gold-fish—and give it a twist round, you will notice that, though the bowl turns, the water inside does not; the fish remain in their old position. If there were a rod projecting from the side of the bowl, it would, of course, move with it, and if a fish came in its way would strike against it. This is the principle of the semicircular canal. For if we turn our head, the tube of the canal turns, passing over the liquid in it, which of course does not move, though it appears to flow in the opposite direction. The consequence is that the hairs on the side of the knob in the direction in which the head is being moved are pressed upon by the dome of jelly, which, as it floats in the liquid, tends to remain where it is. The nerves, stimulated in this way, inform the animal generally of the movement.

These little organs are very important to us, though we have our eyes to correct our ideas of position, and they are still more so to the fish, which dart and turn in the wide expanse of the ocean, and the birds and bats, which wheel about in the air. There are, however, some occasions when we do not feel inclined to bless them; for, inasmuch as they faithfully report every roll and plunge of a ship to a person on board, it is they which are mainly responsible for sea-sickness.

And now that we have seen how the body lies with regard to the external world; how it is efficiently protected from its surroundings; how it is placed in communication with them; and have briefly examined the organs by which it makes its chemical and physical investigations, looks out into space, and is kept aware of what is going on therein, we may return to the means whereby it responds as a whole to the stimuli thus reported—the central nervous system—and try to learn how the right response is brought about.

There is but one thing more to describe in the mechanism of the body—the connecting link between the last two sections. In the last we saw how the body receives stimuli from the external world; in the one before, that when these stimuli reach the central nervous canal it in turn stimulates the organs to perform such movements as circumstances require. What, therefore, remains to be described is the working of that canal by which these necessary movements are ordered and controlled.

Now, in speaking of reflex action a few pages back, we said that the nerves which bring in stimuli from the periphery distribute them about the neural canal to those cells whose activity, by sending out fresh stimuli to the muscles, produces the requisite movements. These motor cells, however, are not scattered about the spinal cord anyhow. They are collected into clusters, or nuclei, as they are sometimes called, and each cluster has special duties—i.e., a special organ to control. Thus, we say that there are in the central nervous system centres—a nervous centre to control the leg; another to work the diaphragm; another for the muscles of the ribs; more for the arm, hand, etc. And these centres are in communication with one another, so that they may not pull different ways.

In the first example of reflex action given in Section II. of this essay, the sensation of a pin-prick was first conveyed to the centres controlling the limb injured, by whose activity it was drawn away from the danger. But the nerve which gave the warning which produced this elementary movement distributed the impression that something was wrong to the higher centres, so that the whole body was involved in protecting, doctoring, and avenging the outraged member; from which it would appear that the lower centres are under control of higher ones. And this is the case. If we may be allowed the metaphor, there are captains of tens, who are under the direction of captains of fifties, and the captains of fifties receive their orders from captains of hundreds. The nerve canal, the manner of whose formation as a simple tube is shown in Diagrams 5 and 42, has therefore different functions in different parts, and this to such an extent that considerable differentiation in bulk and structure is produced.

The neural canal may be roughly divided into two parts—a comparatively simple tube, running the greater part of the animal’s length, containing many centres from which nerves run to the organs they control; and a complicated bulbous enlargement at one end, with thickened walls, in which are the centres controlling those in the cord, and thereby managing not so much organs as the whole animal. The former is called the spinal cord, the latter the brain.

This division, accustomed as we all are to take it for granted, offers plenty of food for reflection. Why should an animal have such a brain placed in its head? Why, indeed, should it have a head, regarding that member as a group composed of eyes, nose, mouth, ears and brain? The mouth gives us the key to the riddle; the mouth is the essential organ, and all the rest are its accessories.

In the first essay we saw that the basis of life was chemical, and in the second that the materials necessary for the chemical action, or food, must, in the higher animals, be taken into the digestive tube through the opening which we call the mouth. Therefore, as it is highly important that only the most beneficial substances shall be received into it, and that all which are actively injurious shall be excluded, it is plain that the organs of chemical perception must be placed in its neighbourhood—the organs of smell to enable the mouth to find its food, and the organs of taste to aid in selecting it. As, moreover, our humble ancestors, the fishes, move literally mouth foremost, it is not surprising to find the organs of space perception, the eyes, also situated in its neighbourhood, especially when one considers that their food is often of a lively character, and requires precision of movement to secure it. The inevitable consequence of thus grouping the more important organs of perception under the fore-end of the neural canal is that it grows and develops more highly here than elsewhere along its length, and soon is in a position to dictate to the rest of the body. Another reason why it must develop is that it must contain centres for turning its impressions to practical account, not only by producing complicated movements in the jaws, eyes and gills, but also by ruling the centres in the cord, and instructing the body to carry the mouth whither it needs to go.

In the preceding diagram (60) the origin of the brain is shown as a dilatation of the end of the neural canal into a bulb with thickened walls, which has already become constricted in places, so that it is subdivided into three. The next diagram (61) is intended to give, in no matter how crude and schematic a way, some idea of the lines on which the development continues. We do not show all, or even half, the structures which go to make up the brain. To do so would be out of place in a book like this. Further, we shall endeavour as far as possible to speak of the brain in general terms, avoiding the five-syllable bastard Græco-Latin names with which the early anatomists have endowed almost every square inch of its substance, and confine ourselves to summing up its functions as briefly as can be done with justice.

In pursuance of this method, attention must be drawn to the fact that only the foremost of the three original bulbs (marked A in the diagram) and the hindermost (C) continue to grow. The middle one (B) remains comparatively simple. From the foremost lobe buds grow out to form the eyes in the manner which we have already described, and other buds push forwards to meet the nerves from the nose. The latter have, even in the early stages shown in Diagram 61, reached an extraordinary size; and when we come to trace them further, we shall find that they become very complex, and acquire remarkable and unexpected powers, considering their humble origin. Strange changes also take place in the hindermost bulb. It splits along the top, so that the cavity it contains is open like a saucer, though bridged over by a three-lobed body called the cerebellum.

Following the spinal cord up into the brain, we are conscious of no sudden line of demarcation separating the one from the other, only of an increasing size and complexity. The lower parts of the brain send out and receive nerves much as the cord does; three pairs go to the muscles which turn the eyes; other pairs bring in sensations from the face and throat; others control the muscles of the face, tongue and throat. But the brain differs from the cord in being directly connected by nerves, not only with adjacent parts, but also with the distant and more important organs in the interior of the body—heart, lungs, etc.; in containing groups of cells which have stimuli sent on to them from all over the body viâ the cord; and in possessing centres which control those lower down in the nervous system. It therefore not only receives and balances stimuli from all over the body, but, by governing the centres which preside over the bodily movements, is able to wield and direct the body as a whole.

The hinder divisions of the brain, which we shall consider first, have no connection with consciousness or volition. They only produce reflex movements, which, however, owing to the wealth of material they have to work upon, are wonderfully complex and far-reaching.

Let us take a few examples. In the hindermost division of the brain (C in the diagrams) there is the centre which presides over the oxygen supply, the importance of which we saw in the essay on vital chemistry. This centre perceives when the lungs have been filled with a gas, and causes them to be emptied; it perceives when they are empty, and again does not allow them to remain too long in that state, before ordering an inspiration; it notes the quality of the air which is passing through the nose, and it notes the quality of the blood which bathes its own cells. The condition of the blood, indeed, is closely watched. An excessive quantity of carbonic acid gas, poverty of oxygen, even temperature, all produce through it an effect upon the rhythm of the breathing.

Close by the respiratory centre is the centre which controls the circulation. But enough has been said in the section on reflex action, wherein the process of fainting was described, to give an idea of the part it plays in the body; so it need not detain us here.

We cannot, however, pass over its neighbour, the centre of temperature, so briefly. Its methods not only afford one of the most striking and interesting examples of harmonious regulations by reflex action, but the subject of temperature itself is so important that we must describe in some detail how that of the body is kept level.

As we said when discussing protoplasm generally, life—that is, the change always going on in the protoplasmic substance—is influenced by temperature: the single cell becomes less active at a low temperature, and dies at a high one; so obviously there is a temperature at which its functions are most easily carried on. Inside the body the cells are all kept at the temperature best for them by the circulation of the blood; but the absolute temperature of the whole body depends upon the heat which is generated within it by chemical action, and the heat which it loses to, or receives from, its surroundings. Under normal conditions this temperature in man is 98·4° F., when the production of heat from its own metabolism is balanced by the loss of heat by radiation. If, however, the atmosphere be very hot, less heat is developed in the body, the general metabolism being slower; and more heat is lost, since by reflex action the skin is bathed in sweat and cooled by its evaporation, and the small bloodvessels under the skin are dilated, so that more blood being brought to the surface, its chance of being cooled by radiation is thereby increased. If, on the other hand, the atmosphere is cool, the loss at the surface is minimized by constriction of the cutaneous bloodvessels, and a checking of the perspiration and consequent evaporation; while internally more heat is generated by increased metabolism. The cells which are mainly responsible for the production of heat are those of the muscles; and when much heat is required they increase in activity, not only in their general tone, but even by a visible movement, which we describe as shivering. So, within reasonable limits, whatever the temperature of its surroundings may be, that of the body remains the same, and though we may raise or lower our temperature by lying in a hot or cold bath, reflex adjustment of the sweat glands, bloodvessels and muscles brings it quickly back to normal when we emerge.

With a passing mention of the cerebellum, the three-lobed organ shown in Diagram 61, and seen again in a more advanced stage in Diagram 63, we may dismiss the two hinder divisions of the brain.

The cerebellum lies on the upward path of fibres from the cord to the higher centres in the fore-brain. It is a somewhat complicated organ, and its functions are not yet fully known. The older physiologists took a very extreme view of its importance, assigning to it, among other romantic duties, that of providing a habitation for the soul. This opinion on the strength of later research we can hardly endorse. The cerebellum really seems mainly concerned in co-ordinating the action of the muscles, especially in maintaining equilibrium in standing and walking.

Our knowledge of the whole brain is very far from complete. We should like to know the peculiar function of each little group of cells that can be made out under the microscope, and the paths of all the fibres connecting the different parts of the nervous system. As it is, we have to wait with the best patience we can while they are being investigated, and hope. In few departments, however, have the labours of the physiologist proved more fruitful and interesting than in the study of the fore-brain (A in the diagrams).

In the simpler form, as shown in Diagram 61, A, and Diagram 62, Fig. 1, A, the fore-brain is remarkable in that it throws out buds for the two most important sense organs—those of sight and smell. So important are these senses, especially in our humble ancestors, as we have already pointed out, that it is not surprising to find the impressions of the other senses brought on up from the hinder parts of the brain to be compared with them. The fore-brain is, in fact, a sort of terminus whither the whole of the afferent or incoming stimuli are brought, and whence, since information is only received in order to be acted upon, the supreme orders to the body issue.

In the fore-brain there are centres for specially governing all the motor organs; but by a strange arrangement the main root of the brain is overwhelmed by its own offshoot, the hemisphere, or lobe which gives rise to the olfactory bud. In fact, so great is the importance of the sense of smell to an animal whose one object in life is to find food, that, instead of the hemisphere being subordinate to its parent, it seems to take over most of the latter’s business, receiving a report of the sensations collected by it, and sending out orders upon its own initiative. Yet, unimposing though the history of this division of the brain may be, it ultimately becomes the seat of consciousness, whereby the mental processes are carried on, and whence all voluntary movements spring.

Of course, in order to do this, the hemispheres have to grow considerably, and thus we find them enveloping the rest of the fore-brain and swamping it in structure as well as in function. Diagram 62 indicates how this is done, while Diagram 63 shows roughly the proportion and position the different parts of the brain ultimately attain. Finally, Diagram 64, which is rather more realistic, but still much simplified, presents a view of the organ in the head.

The size of the cerebral hemispheres, compared with the rest of the brain, is especially remarkable. So, too, is their endeavour to increase their surface still more by throwing it into deep folds. (See Diagram 64.) These two features vary with the position of the animal in the scale of development; in man, who stands highest in intelligence and dexterity, the hemispheres are very large indeed compared with the other organs, and seamed all over with a maze of winding furrows. Another remarkable feature is the extreme degree to which specialization is carried out. Different parts of the body are represented, each by a small area of the cortex, or surface layer, and we know at what spot on the cortex such sensations as sight and hearing are perceived, and from exactly what little patch the impulse to move each limb emanates. In the accompanying diagrams (65 and 66) these areas are mapped out, their locality being fixed by the principal folds which act as landmarks on the surface of the hemisphere.

There is another important fact which we must not omit to mention in speaking of this localization: each hemisphere presides over the opposite side of the body. Early in development the nerve fibres from the eye cross over to the opposite side of the brain, and the afferent fibres from the lower parts of the body have accordingly to follow suit. Then, as the efferent fibres—i.e., those which set the muscles in motion—have to bring about the movements in response to information received, they must also cross to get back to the side from which it came. So, if a tumour grows inside the head on the right side, it is the left eye which becomes sightless, or the left hand which grows numb and powerless, according to the part of the cortex which is pressed upon.

Perhaps the most interesting part of the whole body is that little band of the cortex running upwards from behind the temple to the crown of the head, in which (cf. Diagrams 64, 65 and 66) the motor areas of the limbs, and the perception of those sensations which we have grouped together and called ‘touch,’ are situated. The minute structure of this region is roughly shown in section in Diagram 67, as it has been made out with the microscope; but only a few of the nerve cells are shown, the connective tissue of feltwork in which they are suspended, and the bloodvessels by which they are nourished, being left out. All the structures represented are of course very, very small; the large black patches which represent cells would really be invisible, and the whole field of the diagram only a mere speck, to the naked eye.

A represents the nerve by which impulses are brought in. It runs straight up to the surface of the cortex, and there its branches end, interlaced with those of a many-branched distributing cell (B). The two cells (C and D) shaped like pyramids, which send up branched processes from their apexes, receive an impulse from the distributing cell, and transmit it along the fibre which runs downwards from the middle of their base. Where the fibre from the smaller one goes to we are not sure—probably to another part of the brain to insure harmonious working—but the large pyramidal cell sends its fibre right away through the lower parts of the brain, passing the cell-stations they contain, on into the spinal cord, till it reaches the centre there, which immediately works some particular limb.

Supposing we anæsthetized somebody, throwing him into deep unconsciousness, and then opened his skull, laying bare the brain as is done in Diagram 64, only not quite in such a wholesale manner. If we then stimulated the part of the brain we are now considering at different places with electric needles, using a weak induction current, we should see him moving different members according to the different regions touched—now an arm, now a leg, now the whole head. If we were to place the electrodes in the centre for the hand, and then gradually increase the strength of the current, the activity of the hand centre would throw other centres into activity. The arm would move next, raising the hand towards the face. Then the eyes would turn, and the whole head to meet the hand. Lastly the mouth would open. The movements are those of putting something into the mouth—the ruling passion strong in unconsciousness.

Such experiments were, of course, first made upon animals, but they have been fully verified on the human subject. The story of how this was done is not, however, a romance with a martyr or a criminal for the central figure. The corpus vile was not provided by a volunteer, or kidnapped and bound in a dark cellar, but treated as a patient in the airy wards of a hospital. With increasing knowledge of the brain, it was found that epilepsy was cortical in origin. A little piece of the cortex becomes diseased and hyperexcitable. The sufferer suddenly becomes acutely conscious of one of his members—a hand or a foot, say—not because there is anything the matter with it, but because the corresponding area in the brain is morbidly active, and he refers the sensation to the part from which it receives its nerves. The next moment the limb begins to twitch, and the excitement spreading, as in the experiment we described above, to other centres which are not diseased, they, too, become morbidly active, and the whole body is thrown into convulsions. This is a disease which must be checked as soon as possible. The surgeon accordingly lays bare the part of the brain affected, knowing now where to look; finds the exact spot which is diseased by reproducing the first twitchings of a fit by electric stimulation, and removes the source of the trouble.

Returning to general considerations, an important point is the way in which the different centres are connected by fibres, which put them into relation. The brain may consist of many centres, just as the body consists of many organs, but both body and brain must live as a whole. If the heart and lungs get out of harmony there is trouble, and if the bridge which connects hearing with motion in the brain breaks down, as occasionally happens for a time in an overworked man, he is mentally at a discount. He can hear and understand, but he cannot write or talk sense: he is sane, but quite helpless, and generally very frightened.

Still more important are the intermediate stations and sidings on these lines of communication, for it is here that the most exhaustive weighing and comparing of incoming stimuli is carried on—the final balancing before a voluntary action; in a word, thought.

These courts of inquiry are called association centres. It used to be believed that they were all in the fore-part of the brain, under the forehead; but this is evidently not the case. Several men in war or by accident have had the frontal lobes of their brain damaged beyond repair; and when they have been discharged from hospital, where, thanks to the advance made by surgery since anæsthetics and antiseptics were discovered, they have been successfully treated, they have gone back to their work seemingly in no way different from men whose brains were whole. In some cases they have even been reported as having become quicker and sharper than before, probably owing to there being fewer association centres, and thought being accelerated by simpler machinery: facts are thenceforward shaken through a larger-meshed sieve.

A few general considerations, and we have done. There is no centre for memory in the brain. The facts which we remember are not stored as in a box, nor can one imagine how they could be, considering that the physical basis of an idea is molecular change. The whole nervous system is probably concerned in memory, a particular change, which has momentarily occurred in its tissues, being more likely to occur again under certain circumstances than a fresh one, and certain tracks becoming well beaten and more permeable than others. Pleasure and pain are other general phenomena: they are not to be localized in the brain like vision or hearing. Pleasure is the consciousness that the whole body is under favourable conditions; and pain, the knowledge that the protoplasm of certain cells of the body is being acted upon by injurious agents, chemical or physical. There seems to be good evidence that separate nerves convey impressions of injury, distinct from those of touch and temperature; but it is the revolt of the whole body against conditions affecting a part which constitutes pain.

Amidst the maze of perplexities which lies between physiology and psychology, there is, however, one fact which stands out clear and bold: the brain can create nothing. We have seen how matter is taken into the body and matter is cast off from the body. We have seen how energy is released in the body from chemical compounds, and made use of by the body. So now, after a moment’s thought, it must be plain that every stimulus which goes to the brain must have its effect there, and that a man’s thoughts and conduct are entirely dependent on what has, at some time or other, come in from the external world. The association centres can evolve wonderful thoughts, but they are structurally derived from the grosser sense organs, and must get all the material they work upon from them.

The nervous system puts the body into relation with the external world as a whole, but for convenience it is subdivided into the afferent system, by which impressions come in, and the efferent system, by which the muscles are set in motion. Of the two halves, the afferent system has a just right to priority, for the efferent system is merely its consequence. Sights, sounds, smells, etc., reach the brain by afferent paths from the external world, and are there moulded into thoughts. Their effects we see in poetry, architecture, sculpture, or laundry work, according to the method of the brain in treating the raw material it receives, and of a quality corresponding to the fineness with which the brain examines them, and can control the motor organs of the body.

Whatever goes in at the afferent door, and some people’s sensory apparatus is much more easily affected than others, produces its effect within. Sometimes the energy is expended in thought, sometimes in action; sometimes it trickles away as laughter. But all these phenomena have a material basis: matter producing changes in matter. ‘Those delicate tissues wherein the soul transacts its earthly business,’ as Stevenson so picturesquely describes the brain, stick to their earthly business. There is no astral department opened yet. A man may evolve a great idea from the data he receives, but he must give it a material coefficient if he does not wish it to be lost to his earth-bound brothers. He may write it in a book, or he may sculpture it in marble; but the most convenient means of communicating with his fellows is by sound, which he can command by expelling the air in his lungs over vibrating cords in his throat. These cords are adjusted at the position and tension to give a desired note; and the cavities of the chest, throat and mouth acting as resonators, a noise is produced, which is shaped by the tongue, lips and teeth into words.

By means of language the human body is enabled to co-operate with others of its kind for the development of the resources of the earth, the shaping of society, and the forming of individual character. But here physiology ends and other sciences begin.

ESSAY V. THE BODY. — I. — II.

Such, as far as it can be compressed into four short essays, is the nature of protoplasm. We have sketched out its powers; described how it exists only in the form of a cell; and shown how cells, by forming a community and sharing the work, simplify the business of living, and secure great advantages for themselves individually. But now we have something fresh—the body.

The body is an organic whole, like the cell. It is composed of cells, but these cells only develop one of their many powers to its utmost that they may justify their existence in the community; they do not acquire fresh properties. So really the body is merely a mass of protoplasm in which—though in a greater quantity—the same changes are going on that we find in a single cell. Yet how utterly different is the body from the cell! what a wide gulf yawns between a man and an amœba!

The body has powers of its own, distinct from those of protoplasm; and the protoplasm may still be alive when the body it helped to compose is dead. A few thousand pounds of protoplasm could not have built Westminster Abbey, but a few hundred men did; for just as out of protoplasm arises the body, so the body gives rise to the mind, a thing as much above it as it is above the cell.

So far we have taken the cellular units as our starting-point in discussing life; but a bird’s-eye view of physiology would be incomplete which contained no mention of the major tactics of protoplasm—the life of the body. We must consider the needs of a man as such.

A man requires, as we have described before, air and food. The air must contain the proper amount of oxygen, and the food must consist of liquids and solids.

The important liquid is water. More than half by weight of the whole body is water, and we are always losing it: through the skin, through the lungs, and through the kidneys. People may drink alcohol with water, but not instead of it. Indeed, the more alcohol they take, the more water they require, for if they take their spirits in an undiluted form, they take water out of the body. If you dip a piece of wet cloth into alcohol for a minute, it dries with remarkable rapidity, because the water has been absorbed out of it. In the same way, if you drink neat spirits, they pass into the blood and stimulate the nervous system, ultimately being excreted by the kidneys; but on their way through the tissues they absorb a great deal of water, which must be replaced.

Milk is often spoken of as the ideal food, and so it may be for very young animals; but it lacks one important constituent—iron. A young animal is born with enough iron in its body to do without any in its food until it can take something better than milk. If it is weaned late it becomes anæmic. An adult animal requires iron and also a certain amount of solid food. Its alimentary canal is provided with a good deal of muscle; and this muscle, to be kept healthy, must have something to work upon—in fact, be exercised.

A man’s food should contain a certain amount of coarse material—cellulose, for instance, which forms the envelope of vegetable cells. And here we see a distinctive feature of the body. Protoplasm can make no use of cellulose, there is no digestive juice which will act upon it; but its presence in the alimentary canal in the form of husk and small seeds stimulates the walls by contact, and produces peristaltic movements.

In Essay II., which dealt with the chemistry of the body, we said that if we were only to live upon meat we should tax our digestive apparatus severely by having to eat more proteid than we required in order to get enough carbon. The converse, however, is equally true: if we fed only upon vegetables, we should again have to over-eat. Plants most of them contain large stores of carbohydrate; potatoes and rice are rich in starch, onions in sugar; but an exclusively vegetarian diet would necessitate our consuming huge quantities, as its proteid-supply is bad. It is defective not only in amount—for sometimes, as in beans, the proportion is fairly large—but in being so indigestible that a good deal of it passes through the body unabsorbed.

Both science and experience teach that we live most economically upon the carbohydrates of vegetables and the proteid of animals, and that our food is the better for being cooked. In cooking, parasitic animals which are strong enough to survive the ordeal by acid in the stomach are killed, and the food itself is made more accessible, the indigestible cellulose envelopes of the vegetable cells being burst open, and the collagen of the connective tissues converted into gelatin.

No less important than the quality of our food is the quantity; and here, again, we get a good illustration of the necessity for regarding the body as a whole. A healthy man’s appetite is his best guide, and if he follows it he cannot go far wrong. People who arrogate to themselves a wisdom superior to that of Nature little know the harm they do when they force food down an unwilling throat. The cells of the alimentary canal digest and absorb what is sent to them, minding their own business, which is not to criticise the appetite.

So the digestive and excretory systems embark on hard and profitless labour, and the whole body suffers.

Passing on to another subject, we find that the body eats that it may work, and works that it may eat. This cycle comes naturally enough to animals which have to go and find their food, but men with a sedentary occupation have, in view of the artificial conditions under which they live, to take constitutional exercise.

There are many reasons why the numerous and bulky muscles with which the body is endowed must be constantly used. In the third essay in this volume we saw that the flow of the lymph and the blood in the veins is largely dependent upon the movements of the limbs. Muscular exercise, therefore, must be taken to prevent the circulating streams from growing sluggish. Obviously, many evils must arise if they do so. Not only would the muscles be starved by the slowness with which they received their food, but they would also be poisoned by the slowness with which the products of their own metabolism were removed. The blood-stream would become tainted, and the brain, which requires pure blood, would suffer.

In other ways, however, than by their action on the vessels themselves do the muscles help the circulation. Exercise has secondary effects upon the circulatory and respiratory centres in the base of the brain, and makes the heart beat more strongly and the diaphragm contract more forcibly. The influence of the latter upon the circulation we have already described; but its vigorous action is required not only to aid the circulation through the liver and viscera, but to inflate the lungs to their fullest extent. In the breathing of a man who takes no exercise only a small part of the air which the lungs hold is pumped out at each breath, the greater part remaining stagnant in chambers which are practically unused. Thus, not only is the revenue of oxygen diminished, but there are numerous little crannies in the body filled with still, warm air which are ideal nurseries for bacteria. The devil of consumption does not allow such dwellings to long remain swept and garnished.

Without exercise the sweat glands of the skin will not act, and its pores get closed up. The muscular coats of the alimentary canal, too, reflect in their state of health the condition of the voluntary muscles; laziness is followed by constipation, for if the voluntary muscles rust, so do the involuntary.

The muscles, moreover, must be well developed and kept in a healthy condition for their own sake. They form a large part of the whole bulk, and no healthy man can have unhealthy muscles. Ignorant people sneeringly say that they have no ambition to lift weights or bend pokers; but they should remember that they are dependent upon their muscles for their bodily warmth, and also to save their internal organs from being oppressed by their own weight.

The bones of the skeleton do not rest one upon another; they are jointed, and kept slung in position by springing bands of muscle attached to their levers. If these muscles are not properly developed, they tire under the strain of holding the frame up, and a disastrous rearrangement of the organs is made to save labour. The chest is drawn in, the hips and knees thrust forward, and the man stands with cramped chest, compressed viscera, and his diaphragm under dire constraint. The result of the redistribution of weight is that his bones tend to rest upon one another like a column of bricks, and his whole weight is upon his heels. Such an individual cannot walk; he stumps along, jarring his whole body at every step.

A pleasant contrast is the athlete. The athlete is a man who endeavours to develop the latent powers of his body to the utmost; and in the achievement of this desirable object the physiologist takes great interest. Physiology has revolutionized our ideas of training, as well as many other things, during the last half-century. We now recognise two kinds of training—the preparation which a healthy man makes for an occasion on which unusual exertions will be expected of him, and the slower and permanent strengthening of the whole body, now usually called physical culture. The former is a comparatively short process now that athletes no longer think it de rigueur to live in bestial intemperance when they have no contest in immediate prospect. A little extra exercise, to stimulate excretion and clear away any waste products that may have accumulated in the tissues; a little extra proteid in the diet, since there is at first a slight inclination to growth; a good deal of extra carbohydrate, since the muscles want extra fuel; rest—and the man is ready. Many athletes live continually in training, and are ready at any moment to ‘fight for their lives.’

The second kind of training is for those who are weakly or those who wish to excel. Its object is not only to improve the health, but to increase the absolute strength and size of the body, and its effects are permanent. It necessitates careful diet and constant exercise for a long period, and proves equally beneficial to both sexes. This book has been written in vain if the reader has not grasped by now that the activity of the muscles implies the activity of all the organs in the body. Accordingly, the whole muscular system is by appropriate methods given frequent exercise: gentle at first; never exhausting; but constantly increasing as the strength grows. The result is a general development of the organs throughout the body, which will in time work a complete metamorphosis in the individual’s physique.

Yet by strength alone no athlete can excel; success depends upon skill. He must have the strength to work with, but he must have the knowledge to apply it without wasting energy, and the ability to do this with precision. He must practise well the sport he intends to adopt—in other words, train his central nervous system.

Here, again, we must hark back to the main idea—the unity of the body. We have already dealt in this essay with the bodily needs in the way of food and exercise, and we must now consider the needs of its nervous components. The chief of these is education; but education of the nervous system means, of course, education of the whole body. There are still people who cling to the old fallacy that the mind can be developed at the expense of the body, but a visit to a hospital or a lunatic asylum will afford many opportunities of seeing how Nature avenges ill-treatment of ‘those delicate tissues wherein the soul transacts its earthly business.’ Physical culture must come before mental: Mens sana in corpore sano—hackneyed, but true.

I do not, of course, say that a man must develop equally both his body and mind; only, that the former must be functionally competent. The absurdity of supposing that the brain can benefit by forming part of an unhealthy body is, surely, obvious to all. Determined invalids may produce splendid work, as Darwin did, in spite of ill-health, but not because of it, and men of great mental energy will sometimes wear themselves out prematurely by their restlessness; but starvation and maltreatment of the body will not create intellect, however morbidly it may stimulate the imagination.

Granting the tenement of a healthy body, the education of the central nervous system must proceed along four distinct lines. A child must learn useful reflex actions, such as walking; have its association centres trained, that it may reason quickly and correctly; be endued, if it is not to live upon a desert island, with a sense of moral responsibility and ethical principles; and have its head stored with useful facts, from the meaning of words and the A B C to the value of the coinage.

Few people seem to realize how much a child has to learn before it gets to the A B C. It begins life with very little beyond a capacity for learning, and even its sense organs tell it little until it has had practice in using them. If baby is so unfortunate as to get a scratch from a pin, he wriggles, and makes the whole house aware of it; but he does not seem to have a clear idea at all as to where he is hurt. He has to learn the way about his own body. He passes his hand over his face, and learns that he has features with a definite position and magnitude; he then waves his arms in the air, and learns that there is such a thing as empty space; finally, he knocks his knuckles against the edge of his cradle, and learns that there are other things in existence besides himself. Of course, his eyes help him considerably to form his ideas of things, but his eyes tell him nothing until he has learnt how far to believe them by correcting their impressions by touch. He learns the properties of matter by experiment, not intuition.

Very interesting experiments have been made upon people who have been born blind, and to whom sight has been given late in life by an operation. They generally take some time to appreciate their good fortune. Things, they say, are all pressed up against their eyes, and they are afraid to move. Objects with which they have carefully been made familiar before the operation—wooden spheres, cubes, cones and prisms—they have been absolutely unable to recognise by sight until they have handled them. They have mistaken sparrows for tea-cups, and it is sometimes only after weeks that they have suddenly discovered that pictures are something more than a mixture of irregular splashes of colour on a flat surface.

Babies have to learn to interpret what they see in much the same way, and take longer about it. The child who cries for the moon is probably not so unreasonable as people think. He focuses his eyes upon the little, bright, sharply-defined disc, and it appears to him, if not actually within arm’s length, at any rate near enough to be caught with a butterfly-net. It is only after he has seen it sink behind a large tree on the distant horizon that he gathers a vague idea of its real size and remoteness.

The term ‘physical culture,’ as usually applied, is supposed only to mean the development of the muscles and viscera; really it only begins there. After the organs of nutrition have been got into a healthy state the motor organs are developed. Finally the nervous system should be trained. Mere muscle will not make even a good runner. He must practise carefully till he can take his full stride, and do so without wasting energy by any needless movements. Then he must make the action which his brain has decided is the most effective for his build the property of his spinal cord, that in a race he may use his strength economically, with his thoughts free to deal with the tactics of his opponents and the peculiarities of the course, or he will not make his supreme effort at the most advantageous moment. This is only one instance. Many men having a normal body develop organs of perception, not motion: the musician and the wine-taster, as well as the juggler and the athlete, are products of physical culture. Even the philosopher must foster the physical basis of intellect.

The education of the nervous system goes on all through life; and just as oft-repeated actions become automatic, so are habits of thought formed which are almost as regular; in fact, we might almost call them cerebral reflexes. Without constant exercise, men lose their flexibility of mind as well as of body.

But we have already passed the boundaries of our subject, and it is time for us to pull up, lest we trench further upon another science; for the study of the mind is the province, not of the physiologist, but of the psychologist.

Notwithstanding the strange powers of protoplasm, and notwithstanding that these are accumulated and intensified in the body, as we saw in the last chapter, there are immovable limitations to vital activity.

This is a fact familiar to all. We can trace diminishing vitality through a series of stages, from slight fatigue right up to death itself. Sleep is perhaps one of the most interesting, though it is little understood. During sleep and the hypnotic trance, we know that the cells of the hemispheres pause in their work and chemically recruit themselves; that there is an interruption of consciousness; and that changes occur in the respiratory and circulatory, and, in fact, in most of the functions. But exactly how these states are induced we do not know. It has been suggested that during sleep less blood passes through the brain; but this is unlikely, and still less probable is it that the nerve cells draw in their processes and shut up like sea-anemones, as another daring theorist supposed. We can only draw parallels between the cells of the central nervous system and any others; all need rest.

The simplest unicellular animals, which we have mentioned so often already, spend their lives in alternate spells of activity and rest. In the third essay we mentioned briefly the weakening of each successive response when a muscle, in which tissue fatigue has chiefly been studied, is stimulated. Before the muscle contracted it contained a form of sugar; when it is tired the sugar is gone, and has been replaced by the products of the chemical action by which the energy was evolved. A period of rest must then follow, for the muscle to be cleansed and replenished. The case of glands, described in Essay II., is somewhat similar. After the gland cell has discharged its ferment, it must spend some time secreting a fresh stock before it is ready to discharge again. In fact, a cell seems to load itself up with supplies, like a locomotive with coal, and, after working till the fuel is nearly exhausted, it has to stop to take in more.

All the cells in the body rest at times; even the cells of the heart, carefully as they are nourished and incessant as their work seems, rest between each beat, and the cells of the nervous system form no exception. The brain no less than the body requires periodic rests to renew its chemical stores, and these rests have to be all the longer, as during the waking hours the brain works harder and less intermittently than any other organ. It is only because the brain is the seat of consciousness and the source of voluntary movements that these phenomena are suspended during sleep.

Death may seem at first sight a very simple affair, the breaking up of protoplasm into simpler non-living compounds; but the death of the body is anything but simple—in fact, it is not always easy to say when the body is dead. Usually, however, it is considered dead when the central nervous system has succumbed, though the muscles may continue to live for several hours.

Death may begin in many ways. The loss of some organs will bring death only after a considerable time, while the failure of others disturbs its economy fatally, and causes an almost immediate cessation of the vital functions. Any interference with the normal conditions of the brain, heart, or lungs is very dangerous, and it is injury or disease of one of the three which puts an end to most men’s troubles. If the brain weakens so that it no longer keeps the heart beating or the muscles, which fill and empty the lungs, to their duties, the body, for obvious reasons, can no longer keep up the cycle of changes we call life. On the other hand, if the lungs cannot oxidize the blood, or the heart drive fresh pabulum to the brain, that organ collapses immediately, and, if a stream of pure blood is not quickly restored to it, dies. No return of the circulation can then restore it; the death of the rest of the animal must follow.

Being the most delicate, the cells of the central nervous system usually die first, and we then say that the man is dead. So the body may be, but much of the protoplasm of which it is composed—whole organs, in fact—remains alive; the muscles will respond to electrical stimulation, and in case some people may dispute that this is a sign of life, if pieces of his skin be removed and grafted into another person, they will grow there, produce hair, and become, in fact, a part of the new body. This they could not possibly do if they were dead; we cannot endow inanimate matter with life.

As death creeps on over the tissues, the leucocytes die, and in doing so form a ferment which solidifies one of the proteids dissolved in the blood, so that the familiar clotting takes place. By a similar process certain constituents of the muscles are also clotted, the muscles stiffening and passing into what is technically, but also pretty generally, known as rigor mortis. Rigor is said to set in soon after death if the body is kept in a warm place, or if death has been preceded by violent exercise; but death in this instance means only the death of the body. It is at the precise moment that a muscle fibre dies that it passes into rigor. By keeping it cool, so that the processes of life may go on slowly, especially if it be in a healthy condition, its death may be deferred for hours; while, on the other hand, at the end of a severe and protracted battle, exhausted soldiers sometimes die instantaneously on being shot, and are found fixed in the position in which the fatal bullet found them—on their knees, with gun to shoulder, in the act of firing.

But if the manner of death is not to be lightly dealt with, its causes are still more obscure. It seems natural enough that people should be killed by violence or by diseases with an external or septic origin, or even by one particular organ wearing out and involving the whole body in the fate of its part. But why should people die of old age? Why should their vitality ebb till they quietly go out? Life is a mechanical cycle of changes. For a time even after it has stopped growing, the body replaces what it wastes, and keeps itself in a condition of equilibrium. Why, then, without any apparent external cause, does it, after a more or less circumscribed period, enter into a decline? And, finally, could we, by taking the proper precautions, delay or prevent old age and death?

In the first place, regarding protoplasm as a chemical structure, why, if kept under favourable conditions, should it ever break down? We have no reason to suppose that it need. It is hard to see how the minute animals, consisting of only one cell, can die of old age, provided that no injurious influence be brought to bear upon them. When an individual has grown to a certain size, it divides in two, and each enters upon life afresh. Why, therefore, should not all the cells of the body continue to renew their youth?

The reason why the body can only last a certain time, in spite of the many quacks with recipes for immortality—recipes including such items as the avoidance of all trouble, worry, or work—must remain a secret until we know the chemical basis of life. It seems to lie in the cell. If a unicellular organism, as described above, be placed in a vessel of sterilized water and left to live alone under otherwise ideal conditions, it will start dividing and multiplying, as though it meant to reproduce itself indefinitely. After a time, however, the shoal begins to deteriorate; each successive generation is feebler than the last, and eventually all die. If, however, before this happens one of the effete cells be placed in another vessel with a similar individual derived from a different ancestor, the two will fuse and form a single fresh animal with entirely restored vigour, ready to multiply to the same extent as either of its original ancestors. A few individuals of a different stock will in this way revivify the whole brood.

There is, therefore, evidently something in the cell which wears out after it has divided a certain number of times—something which must be restored by blending with cells of another strain. What this is we do not know, and perhaps never shall. The most we know is that it seems to be something inherent in the nucleus, not the main body of protoplasm of the cell, for some unicellular animals do not fuse, under the circumstances related above, but exchange only pieces of their nuclei, and yet derive the advantages of mutually increased vitality. But if we apply the fact to our conception of the body as a vast colony of cells with a common origin, we find that it has an important bearing upon the duration of its life.

The single eggcell which gave rise to our schematic embryo in Diagram 3, Fig. 1, was formed by the fusion of two cells shed by two distinct animals. How this one cell grows and multiplies by division is roughly shown in the diagram and those immediately following it; but though the cells do not separate, but hang together and form a body, it is obvious that the colony only amounts to a shoal of unicellular organisms, like that described above as growing weaker with each successive division unless blended with individuals of a different stock. This cannot be done in the body; what would become of our individuality even if such a thing were possible? The body can help to give rise to new bodies, but its own tissues must wear out, and when the colony of cells is exhausted it must die. Careful diet and regular habits, the minimum of wear and tear, may enable the body to run its full term; but they cannot lengthen the lease of life.

So far only can the physiologist take us. Physiology may teach us how to develop our powers and economize our strength; it is already beginning to convert medicine from an art into a science; it will, it is to be hoped, shortly work a revolution in our at present barbarous ideas of how to rear and educate children; it may, in short, teach us how to make the very most of life and die easily; but not until, if ever, it understands the physical basis of life, and perhaps not even then, will it be likely to succeed in prolonging a man’s days much beyond the traditional fourscore years.

CONCLUSION.

While the physiologist is quietly working, making slow but sure progress, his critics, friendly and otherwise, buzz about him like bees. There are some who are in a chronic state of excitement, expecting a revolutionizing discovery from hour to hour; there are others who assure him that he has reached the limit of human powers of comprehension, and can never know much more than he does to-day; and, lastly, there are those who declare that he has done next to nothing, and that his utmost endeavours have failed to effect any real result, and leave all the important secrets of life untouched.

No one knows better than the physiologist how mistaken is the oversanguine class first mentioned. In no department of science, certainly not in physiology, is it possible to reach the top of the ladder by a bound; each rung must be mastered in order. In invading the unknown land the scientist must thoroughly explore and effectively occupy as he advances. He must annex as he goes along; the flying columns which try to reach the enemy’s capital by a dash are never heard of again. In physiology the publication of the various steps is sometimes withheld until the objective has been reached, but our knowledge of life is like Solomon’s temple: a David collects the material, and his successor raises the edifice. The world watches it grow. It is not like those bewildering and unstable palaces of the ‘Arabian Nights,’ built by genii in a single night, and often vanishing as mysteriously.

In every age there have existed people who declare that men can never know more than they do at the moment. There were plenty of them when the science of physiology was unborn, and there will be plenty more of them a hundred years hence; only then they will refer with tolerant amusement to the crude and elementary ideas of their predecessors at the beginning of the twentieth century.

The third class, who take such delight in minimizing the achievements of the physiologist, usually are found, if anyone takes them seriously, to know very little either about the science of physiology itself or the history of its growth. I leave the reader to form his own verdict upon the value of the results obtained from their exceedingly brief and sketchy description in this little volume, with the remark that the science is barely more than three-quarters of a century old, and the most important additions to our knowledge have been made within the last twenty years.

There were, paradoxical as it may sound, great physiologists before then; the work of Harvey, who three centuries ago discovered the circulation of the blood, is above all praise; but how nebulous must have been their ideas may be seen from the following facts: It was only at the beginning of the nineteenth century that the atomic theory of matter was formulated; it was not until twenty years later that the world was startled by a daring chemist who showed that organic compounds obeyed the same natural laws as inorganic; and not until ten years later was the cellular structure of animals, the groundwork in all study of life, recognised.

Even when the science was set upon firm foundations, progress was at first necessarily slow: the organic chemist took some time in examining and classifying the compounds met with in the body—he has not finished yet; and even when the cell theory was grasped, it required much ingenuity and long patience to devise ways of examining organs under the microscope, so that their structure could be made out. The microscope itself was a poor toy fifty years ago, magnifying a diameter ten times where now it magnifies a hundred, and giving only a dim and distorted image. The perfecting of the microscope, and the introduction of anæsthetics and antiseptics, have led to enormous strides being made within the last two decades.

The result of the advance in chemical knowledge, and the introduction of fresh aids to investigation, led to the discarding of vital force as a working hypothesis. Vital force was the bane of the earlier biologists. They made it accountable for all they could not understand, and with this restatement of their difficulties—a restatement which they called an explanation—refrained from further research. But when it was found that many of these inexplicable phenomena, though refractory, yielded to careful study, and could be explained by chemical and physical laws, the physiologist ceased to say of them, ‘They are problems connected with Life, and therefore explained by Vital Force, which is past man’s understanding,’ and frankly admitted that there were many things which he did not as yet fathom. Recently a vitalistic school has cropped up again, declaring that all that it cannot understand must infallibly be due to some occult agency. It shows remarkable vitality in surviving the shocks of successive discoveries.

Turning once more to the present day, we will conclude with a brief glance round a physiological laboratory, and see by what methods the physiologist is preparing future surprises. The chemical department first claims our attention. The imports and exports of animals are carefully balanced, and the changes produced in the food examined. The animal is enclosed in an airtight chamber, air of known composition being pumped into it, and the air which escapes analyzed. The animal most used for this experiment is man himself, since he will take rest and exercise to order, the latter usually on the treadmill, by which it can be also measured, and can be relied upon not to while away the tedium of his imprisonment by gnawing holes in the walls or upsetting his food.

All the substances used as food, found in or excreted by the body, are being thoroughly studied; but it should be remembered that this is chemistry, not physiology. Physiology is only concerned with protoplasm, and the physiologist who goes deeply into the chemistry of non-living matter has to discipline his mind against forgetting its ceaseless change, and trying to regard it as though it were constant. The actual chemistry of protoplasm will be a very hard nut to crack, and may defy us until we can depict molecules as well actually as we now can symbolically. Some idea of the difficulty may be formed if we consider that it is impossible to imagine a pure sample. From the restless activity which is the condition of its existence, it is always working changes in its surrounding, always mixed with raw material, and always masked by the products of its own metabolism. Even if we withhold the former, it consumes its own substance until the moment of death. It does not even look homogeneous under the microscope.

Before, however, we can pursue the chemical methods further, it will be necessary to describe the histological. The reader may have already wondered how we managed to find out so much about the cellular structure of the body. It is no easy matter to cut up soft tissue, of the consistency of an unboiled egg, into thin slices which can be examined under the microscope. It is done in the following manner: The bloodvessels of the freshly killed body are injected with a fluid which instantaneously kills and fixes the cells in much the same way as an egg is fixed by being hard-boiled. The natural shape of the cells is thus preserved, and the loss of any of their chemical constituents by putrefaction prevented. The piece of organ is then impregnated with and cast in the middle of a solid block of paraffin wax, which is put into a machine and shaved up into thin slices, about 40,000 to the inch sometimes. One of these shavings is then stuck upon a glass slide, and on the wax being dissolved away with some such substance as benzine, a section of the tissue, about one cell thick, is left on the glass ready for microscopic survey.

To do anything like justice to the histological methods would require a volume in itself. When the sections are fixed upon slides, they are treated with a number of reagents to show their chemical and structural peculiarities. One section is stained specially to show the nucleus; another to show the centrosome; another zymogen granules, etc. And, as all these cannot be shown at their best in one cell, the differently treated sections have to be separately drawn or photographed, and the typical structure compiled from several. By careful staining, the chemical composition of the different parts of the cell is being worked out, and the effects of rest, activity, feeding, and other influences, studied.

Take as an example the effects of a meal. A number of animals of the same litter are fed together out of the same trough. One has been killed before the meal, and the rest are killed at intervals dividing the time which must intervene before their next feeding-time comes round. Series of sections from their organs are prepared, one from each animal being mounted in order upon the same piece of glass, dipped in the same reagents, and examined under the same microscope. From a number of these sections the progressive effects of a meal upon each of the several constituents of the cell are traced out, and some of the chemical processes deduced.

Turning to the physical side of physiology, it is unnecessary here to say more about the means employed for studying the properties of muscle and nerve than that many of the phenomena occur with such extreme rapidity that they can only be perceived by the photographic plate. In the study of the large organs, the physiologist finds a fascinating employment in devising models in which, so far as possible, all the physical conditions are reproduced, and this not only for the benefit of his pupils, but to help himself in perceiving their meaning. Too much reliance must not be placed on these models, of course, but they have added considerably to our knowledge of the eye and throat.

It requires no great imagination to perceive the difficulties which lie in the way of studying the nervous system. Tracing nerve fibres under the microscope through interminable series of sections is a labour which can neither be hurried nor scamped. It is greatly aided by pathological specimens. An animal which has been through life with only one eye will obviously have central organs of vision showing wide contrasts. Those connected with the blind eye will be undeveloped, because never used, while the corresponding lobes of the brain connected with the other eye will show the effects of doing extra work.

Many of the problems which meet the physiologist can only be solved by experimenting upon a live animal, and these experiments form by no means the easiest part of his work. The animal must be kept, so far as possible, under physiological conditions—that is to say, free from pain and fright and unpoisoned by drugs. Thanks, however, to an extensive knowledge and skilful use of anæsthetics, the obstacles to this method of investigation have been overcome, and its results have proved very profitable. The absence of pain is a very important factor in an experiment, and even if the physiologist took the wanton delight in inflicting suffering which the imagination of his enemies attributes to him, he would have to restrain its indulgence in his laboratory, or forego the hope of even moderate success. In this country, moreover, the Government will not allow such experiments without its express permission, and the license is very rightly only granted to men whose researches promise an adequate return, and who are likely to conduct them humanely and successfully.

Physiological research is not a hobby to be lightly taken up. It is not one merry round of exciting tussles with tortured and infuriated cats and dogs; on the contrary, it entails arduous labour and needs infinite patience. The experiments, often tedious in themselves, have to be repeated again and again in as many different ways as possible, until every slight difference in result can be accounted for; and the certainty that both the methods used and the interpretation given will, when published, receive the closest, and not in every case the friendliest, scrutiny by other members of the profession serves as an admirable corrective to jumping at conclusions. It is, however, an occupation of absorbing interest, and the physiologist feels amply repaid if he can think that his labours have added, no matter how little, to that control over Nature which the severe conditions of modern life make every day more pressingly necessary.

INDEX

• A.
• Abdominal circulation, 54
• Absorption, 25
• Acid, hydrochloric, 23
• Afferent system of nerves, 92
• Alcohol, 95
• Alimentary canal, length of, 19
• movements of, 46
• origin of, 17
• structure of, 46
• Amœba, 16
• Amœboid movement, 31
• Amount of food, 15, 96
• Animalcula (unicellular micro-organisms), 5, 8, 16, 31, 102, 105
• Aorta, 51
• Arm, 57
• Artery, 48
• Association centres, 91
• Athletes, 98
• Atom, 2
• Auditory mechanism, 74
• Auricles, 49
• B.
• Bacteria, 23, 44
• Beaumont, 25
• Bile, 24, 62
• Blind, experiments with the, 100
• Blood, 26
• circulation of the, 48
• clotting after death, 104
• corpuscles, 29, 45
• course of the, 27, 55
• pressure, 51, 66
• Body, the, 9, 94
• Boils, 45
• Bone, 36, 56, 98
• Brain, 63, 79, 102
• Breathing, 25, 52, 82, 97
• C.
• Canals, semicircular, 77
• Capillaries, 48
• Carbohydrate, 14, 96
• digestion of, 22
• Carbon, 11, 13
• Carbonic acid gas, 13, 25
• Cartilage, 36
• Cavity of the body, 43
• Cell, 4
• a chemical laboratory, 6
• division of, 32, 105
• exhaustion of, 102
• movements of, 5, 31
• nerve, 60, 87
• spinal ganglion, 63
• Centres, nervous, 63, 78, 88, 91
• Centrosome, 31
• Cerebellum, 84
• Cerebral cortex, 86
• hemispheres, 85
• Chemical compounds, 2
• needs of body, 11
• Chemistry of the body, 8
• Chords, vocal, 93
• Cilia, 33
• Circulation, 27, 97
• course of, 28, 55
• mechanism of, 48
• Circulating fluids, 26
• Clotting of blood, 104
• Cochlea, 76
• Cold, 83
• Collagen, 24, 35, 96
• Compounds, chemical, 2
• Conductivity of protoplasm, 59
• Connective tissue, 24, 35, 96
• Conservation of energy, 92
• Contraction of heart, 49
• of muscle, 34
• Cooking, 96
• Cord, spinal, 63, 78
• Corpuscles, red blood, 29
• white blood (leucocytes), 45
• Cortex, 86
• Cough, 65, 67
• D.
• Death, 103
• Diaphragm, 52, 97
• Diet, 11, 95
• Digestion, 11
• by body, 22
• by cell, 16
• Doctor, ix
• Drum of ear, 75
• E.
• Ear, 74
• Education, 99
• Efferent system of nerves, 92
• Egg, white of, 13
• Electric manifestations in tissues, 40
• organs of fish, 42
• stimulation of tissues, 37, 88
• Embryo, development of, 17
• Endolymph, 74
• Enzyme, 15
• Epilepsy, 89
• Equilibrium, 66, 84
• Exercise, 97
• Eye, 73
• education of, 100
• protection of, 65
• F.
• Fainting, 66
• Fat, 14, 24, 27
• Fatigue, 40, 102
• Ferments, 15
• Fibres, connective tissue, 35
• muscle, 34
• nerve, 42, 60
• Fibrils, muscle, 35
• Fish, electric, 42
• Food, 10, 95
• amount of, 15, 96
• vacuole, 16
• Forehead, 91
• Frog experiments on muscle, 37
• reflexes, 68
• G.
• Ganglion, spinal, 62
• Gastric juice, 23
• Gelatin, 24, 35, 96
• Gland cells, 21
• Glands, origin of, 20
• salivary, 22
• sweat, 71
• tear, 65
• H.
• Hæmoglobin, 29
• Hair, 70
• Harvey, 108
• Head, 79
• Hearing, 74
• Heart, 48, 66
• Heat, production of, 13
• regulation of, 83
• Histological methods, 110
• Huxley, 7
• Hydrochloric acid, 23
• I.
• Internal secretion, 29
• Intestine, movements of, 47
• Involuntary movements, 65
• muscle, 34
• Iron, 95
• K.
• Kidneys, 29, 95
• L.
• Labyrinths of ear, 74
• Leucocytes, 42
• Limbs, 56
• Liver, 24
• circulation through, 27, 54
• Living matter, 1
• Localization of function in the brain, 86, 88
• Lungs, 52, 93
• absorption by, 25
• Lymph, 26
• circulation of, 27, 48
• M.
• Marshall’s fibrils, 35
• Meat in diet, 15, 95
• Medicine, ix
• Medulla (hind-brain), 82
• Memory, 91
• Micro-organisms, 5, 8, 16, 31, 102, 105
• Microscope (histological methods), 110
• Milk, 95
• Mixture, 3
• Molecule, 2
• Mouth, 79
• Muscle, 34
• how studied, 37
• of alimentary canal, 46, 95
• Muscles, 97
• of limbs, 56
• stiffening at death of, 104
• N.
• Nerve cells, 60
• centres, 63, 78
• fibres, 42, 60
• Nervous system, 58
• Nitrogen, 12
• Nucleus, 4, 21, 32, 106
• O.
• Olfactory lobe of brain, 85
• sense organs, 72
• Oxygen, 11, 13, 25, 82, 95
• P.
• Pain, 91
• Pancreas, 24
• Paramœcium, 16
• Peptone, 24
• Perilymph, 74
• Peristaltic movements, 24, 63, 95
• Physical culture, 98, 101
• Physiological methods, 37, 88, 109
• Physiology, ix, 107
• Pleasure, 91
• Pressure, blood, 50, 66
• Proteids, 12, 23, 96
• Protoplasm (living matter), 1
• Pulmonary circulation, 53
• R.
• Reflex action, 62, 65
• centres, 82
• Removal of refuse, 27
• Rennet, 21, 24
• Respiration, 25, 52, 82
• Ribs, 52
• Rigor mortis, 104
• Rutherford’s fibrils, 35
• S.
• St. Martin, 25
• Saliva, 22
• Salt, 11, 14, 29
• Scavengers of body, 43
• Sea-sickness, 78
• Secretion, 21
• internal, 29
• reflex control of, 66
• Semicircular canals, 77
• Shivering, 83
• Sight, 73, 100
• Skin, 69
• Sleep, 102
• Smell, 72, 84
• Sneeze, 65
• Sound, 76
• Speech, 93
• Spinal cord, 63, 78
• Spirits, 95
• Spleen, 27, 54
• Standing, 66, 84
• Starch, 14, 96
• Stomach, 23, 47
• Sugar, 14, 96, 102
• Sympathetic nervous system, 62
• T.
• Taste, 72, 84
• Tear glands, 65
• Temperature, 83
• Tendon, 37
• Tetanus, 39
• Thorax, 52
• Thought, 91
• Thyroid gland, 29
• Trachea, 52
• Training, 98
• U.
• Unicellular animals, 5, 8, 16, 31, 102, 105
• V.
• Valves of heart, 48, 50
• Varieties of protoplasm, 6
• Vegetable food, 96
• Veins, 48
• Ventricles, 49
• Veratria, 40
• Vision, 73
• Voluntary movement, 56
• muscle, 34, 56
• W.
• Walking, 66, 84
• Warmth, 83
• Water, 95

Ballière, Tindall and Cox, 8, Henrietta Street, Strand