Though it is impossible to refer every
particular case of fever to a distinct class, on
account of the mixed and anomalous symptoms
that arise, yet there are certain distinguishing
features which afford sufficient
ground for dividing them into different
kinds, and such a division will at least serve
to facilitate description, and to afford room
for laying down the outlines of practice.
The fevers which occurred most frequently
on board of ships, and at naval hospitals
belonging to the fleet in which I was employed,
were the infectious ship fever,
(which is the same with the jail and hospital
fever) the bilious remitting fever, and
the malignant yellow fever.
This does not occur so frequently in hot
as in cold climates, both because it is the
disease of ships newly fitted out, which they
seldom are in the West Indies, and because
there is something in the warmth of a climate
which prevents the production of contagion,
as has been formerly remarked. But
as great fleets arrived from time to time in
the West Indies from Europe, with numbers
of men labouring under this fever,
there were sufficient opportunities of making
observations upon it.
It has been so well described by Sir John
Pringle, Dr. Lind, and other writers, that
it is unnecessary to enter into a minute detail
of all its different appearances in its
several stages; and I shall content myself
with recounting some of the most distinguishing
symptoms, and with marking the
peculiarities that arose from the influence of
the climate.
This fever is extremely various in its
symptoms and in its degree of malignity
and fatality. We are told in some of the
histories of the jail distemper, that, upon
its first attack, few escaped that were seized
with it; but that afterwards it grew more
mild; and it has been already observed, that
the contagious poison of fever differs from
that of small pox and other specific infections,
by varying in its degrees of virulence.
There are, however, certain characteristic
symptoms pretty constant in this fever in all
its forms.
One of the most remarkable of these is a
greater degree of muscular debility than what
takes place in other fevers, and it deserves to
be mentioned first, as being one of the most
constant. It is also a tolerably true index of
the degree of malignity, the danger being
in proportion to this symptom. In the more
advanced stages of the fever, a tremor of the
hands, and of the tongue when put out, is
a constant symptom, and seems to be connected
with this weak state of the muscular
fibres. I have seen, however, extreme debility
without tremor in cases too of the
greatest danger, and it was observable in
these that there was little or no delirium.
Another striking character of this fever is
the delirium of a particular kind which usually
attends it. Sensation and reason are here
in a state uncommonly depraved; and it is
in this sort of fever oftener than any other
that we find a total deprivation of them in
the symptom called coma. The delirium is
seldom of a wild, ungovernable kind, such
as occurs in inflammatory continued fevers,
in the violent paroxysms of intermitting and
remitting fevers, or in inflammations of
the brain. It is, however, connected with
great suffering; and this consists in anguish
rather than pain, shewing itself by outward
tremor, agitation, and what is called the
floccorum collectio; also by sighing, mumbling,
and moaning, symptoms always indicating
danger.
Delirium is a symptom, to the nature and
appearances of which I have been particularly
attentive, in consequence of a painful
and diligent attendance upon some cases in
which I was particularly interested from
friendship and affection, and in which this
was a remarkable symptom. It seems chiefly
to consist in a false reference of our sensations,
whether external or internal; and
this is in no sort of fever more evident
than in this. When any painful impression, for instance,
is made by an external
body, the patient, if in a state of delirium,
does not refer it justly to the part affected;
but the general agitation and incoherence of
sentiments will be aggravated for the time.
I have known a degree of heat applied to
the extremities sufficient to blister them,
yet the part did not shrink, though the raving
and general uneasiness were increased.
In like manner, with regard to internal sensations,
when an irritation is excited to expel
the urine or feces, the mind does not recognize
it as such, but from a sense of uneasiness,
probably mistaken for something else,
an effort is made to relieve nature, which
is done without a proper consciousness, and
certain symptoms are produced which are
well-known marks of danger in this fever.
In watching those who have been under the
influence of delirium, I have observed it increase
when any particular want of nature
urged, and this would continue for some
time, the patient being incapable of procuring
himself immediate relief on account of
the false reference of sensation that has been
mentioned; but he would become calm after
voiding the urine or feces, or after receiving
something to drink, according to the
particular want that was present at the time.
So great is the disorder in the common
course of sensation in this fever, that a person
ill of it has been even unconscious of inflammations
of vital parts, which, in the natural
state of the nerves, would have excited
the most acute pain, and would have been
distinctly referred to the part affected, but
were not discovered nor suspected till inspection
after death89. I remember one case in
which there were found large erosions, and
even holes in the intestines, without any
preceding complaint that could have led to
suspect such an appearance. It would appear
that the motions excited in the brain
and nerves in such cases, instead of producing
the sensations naturally belonging to
them, serve to excite disagreeable emotions
of a different kind, in which delirium consists.
It seems to be from the same depraved
state of sensation, that when a phthisical
person is seized with this sort of fever, his
cough is for the time suspended. I have
seen the same circumstance occur in a maniacal
case. From a like cause it sometimes
happens in dangerous cases of fever, that
in the height of delirium the epiglottis loses
its natural irritability, so that liquids in the
act of swallowing are apt to get into the
windpipe, so as to excite coughing and
threaten suffocation, as I have observed in
some cases that came under my care.
All these different forms of delirium are
signs of a body extremely disordered in its
functions, and forbode great danger.
The next symptom I shall mention as
most characteristic of this sort of fever is,
the spots known by the name of petechiæ
and vibices, which, though far from being
constant, are, perhaps, more peculiar to it
than any other symptom. They occur only
in the latter stages of the disease, and in
cases of considerable danger. The common
opinion concerning their cause is, that the
blood is in such a dissolved state, that the
red part of it is effused into the cellular
membrane. The appearance in such bodies
as I have inspected, seems to favour this
opinion; for there was hardly any coagulation
of the blood in the great vessels, and
instead of those firm substances, called polypi,
in the heart, there were only soft grumous
bodies, which were so tender in their
consistence, that, upon being handled, they,
as it were, dissolved. Since the improved
method of treating these fevers has been
generally adopted, this symptom seldom
occurs; for in most cases it may be called
an artificial symptom, chiefly arising from
close apartments and the heat of bed clothes.
It may be considered as a peculiarity of
this fever, that it is more indefinite in its
crisis than most others. In continued fevers
of the inflammatory kind, there are frequent
attempts at remission, there are certain periodical
exacerbations, and there is generally
a distinct crisis marked by a freedom of the
secretions and turbid urine: but in the fever
of which we are treating, though the patient
is generally somewhat worse towards
the evening and during the night, its course
is more equable, and the transition from
sickness to health is insensible and gradual,
being seldom marked with any perceptible
crisis.
The symptom next to be taken notice of,
though a minute one, is very constant and
characteristic in this sort of fever. It is a
peculiar heat in the skin, communicated to
the hand of another person. It is usual to
grasp the wrist of the patient after feeling
his pulse, in order to examine the state of
the skin in point of heat and moisture; and
in doing this a glow of heat is impressed on
the palm of the hand, which lasts for some
hours, if one should neglect so long to wash
the hands. I have never met with this
symptom in any of the sporadic fevers of
England, though I am informed it sometimes
occurs in these.
The fever we are treating of differs also
from the sporadic nervous fever of England,
and from most others of the continued
kind, in being attended with a more copious
secretion of bile, which, when thrown up,
is generally green, or, as it is otherwise
called, of a porraceous colour. This symptom
takes place in all climates; but is more
remarkable in a hot climate, as might be
expected.
These are the chief characteristic symptoms
of this fever. I shall next point out
such modifications of it as occurred in the
West Indies from the influence of climate.
In the first place, when this fever prevailed
on board of any ship that arrived from a
northern climate, it was soon after succeeded
by, or, as it were, converted into, a dysentery;
for those ships that arrived either
from England or North America with the
greatest stock of feverish infection, were the
most subject to fluxes, after being two or
three months in the West Indies. This
was formerly made use of as an argument,
to prove that the dysentery proceeds from
the same cause with fever, taking a different
determination, from circumstances of
climate and constitution.
Secondly, It sometimes happens that men,
under the influence of this infection, are
more apt than others to be affected with
symptoms peculiar to the climate upon their
first arrival. A very striking instance of this
has been mentioned in the case of men that
were pressed into the Formidable at New
York, some of whom had the common ship
fever on the passage; others, upon our arrival
at Barbadoes, were seized with the yellow
fever, and were the only men in the
fleet who had it at that time. There was
another instance in the recruits brought
from England by the Anson, who were
seized with a fever on board of the Royal
Oak; and in this fever the skin and eyes
were yellow, though without any symptoms
of malignancy90.
Thirdly, It happened in some ships91
that the infection was kept up for several
months after arriving in the climate, from a
neglect of cleanliness, or the want of an opportunity
of removing those who were infected
to an hospital. It did not in these
take a dysenteric turn, as in most of the
other ships, but differed from the ship fever
of colder climates, as above described, in
some particulars, which I shall here enumerate.
All the symptoms were milder:
it was more protracted, and less dangerous.
In the beginning there was but little difference,
only the symptoms were less violent;
but in the succeeding period of the disease
the pulse deviated very little from the natural
standard, and the skin felt cold and clammy.
The tongue was white; and this did not
seem so much owing to any fur covering it,
as to its being itself of a pale, lifeless colour,
as well as the face, and it appeared larger in
size than natural. The teeth were clogged
with a white fur. Those affected with this
fever were subject to faintings, and had a
constant uncomfortable languor and listlessness.
Most of them had a deep-seated pain
in the occiput, and an oppression at the
stomach, but without any inclination to
vomit. The unfavourable symptoms were
coma, delirium and a yellowness of the skin.
I never remember to have seen petechiæ in
any of them. The favourable symptoms
were a warm moisture, or a miliary eruption
on the skin, and a gentle diarrhœa,
which, however, if neglected, was in danger
of degenerating into an incurable flux.
A great number were seized with this fever
in the Alcide, in July, 1783, and what is
remarkable, most of them had the tape
worm, as I was informed by Mr. Telford,
the surgeon of that ship, who frequently
obliged me with valuable remarks; and he
observed also, that it was evidently infectious,
and that the skin communicated the
same disagreeable feeling to the hand as was
mentioned above.
Though the inflammatory fever does not
often occur in hot climates, yet, as it is of
great consequence to distinguish it in all
cases from the infectious fever of which we
are treating, it may not be improper, nor
uninstructive, here to point out the most
remarkable differences. There is more resemblance
in their symptoms, especially towards
the beginning, than might at first be
supposed; and as it is very material to avoid
error with regard to the practice, which, in
these two sorts of fevers, ought to be very
different, and even opposite, I have taken
particular pains to discriminate them.
The continued inflammatory fever is very
uncommon in the West Indies; but in the
form in which I have met with it in North
America and England, there are cases in
which the blood is sizy during the whole
course of the disease, even without local
affection, though, in general, there is more
or less rheumatism, or pulmonic inflammation.
The symptoms which chiefly distinguish
such cases from the fever before described
are, a greater degree of muscular
strength, a more violent delirium, pale
urine, a more parched tongue and skin,
greater heat and thirst, and a pulse more
frequent and strong, with a particular sharpness.
There is another symptom sometimes
occurring, which I consider as strongly characteristic
of a fever of an inflammatory nature.
This is a watery diarrhœa, without
fæces and without gripes, the stools consisting
chiefly of the drink as it was taken in.
There seems here to be a suspension of the
power of absorption as well as secretion in
the bowels, in consequence of a general
spasm on the extreme vessels; for there
is hardly even bile or mucus in the stools.
There is also a particular appearance of the
mouth connected with this type of fever,
which is better learned by the eye than by
description. It consists chiefly in a want
of moisture on the lips, and a dryness and
shining appearance of the teeth. With
these symptoms, it will be found that the
patient will bear the lancet in very advanced
stages of the disease. These fevers seldom
occur but in a sporadic way, unless when
there is some peculiarity of season, as at
New York in autumn, 1782. They are
also more frequent among the better than
the lower sort of people.
By comparing these symptoms with those
of the infectious fever above described, there
will appear an obvious difference in their nature,
and evident reasons for varying their
treatment.
When the body is thrown into disorder
by an attack of fever, the first step to be
taken is to clear the stomach and bowels of
their crude and acrid contents, consisting
either of the food imperfectly digested, or
the depraved natural secretions. So great
is the disturbance produced by such offending
matter, that, when nature is freed from
this embarrassment, the functions of the
body are frequently by this alone restored to
their proper exercise, and a remission produced.
It seems probable also, that this
evacuation proves salutary not only by removing
the morbid stimulus, but by preventing
the absorption of corrupted or ill-concocted
juices into the mass of blood,
which would tend still farther to derange
the functions of life. But perhaps the circumstance
that first suggested the utility of
evacuating the stomach, as the first step in
the cure of fevers, was the nausea so common
in the beginning of them, which may
be considered as a natural indication of this
practice. It farther appears rational, that,
as acute diseases generally come on suddenly,
and find the body in a state of repletion
from the recent ingesta, the most obvious
means of relief should be to free the bowels,
and particularly the stomach, from what is
foreign and oppressive to it. It seems also
probable, that the nausea and the act of vomiting
have a salutary effect independent of
evacuation; for I have seen relief produced
from these when nothing was evacuated.
Such, indeed, is the great and universal influence
and sympathy of the stomach, that
the operation of vomiting affects every fibre
of the body, and has been known to resolve
tumours in the most distant parts. An early
administration of an emetic is therefore the
first step to be taken in the treatment of
this as well as most other fevers.
If it is given in small divided doses, it will
most probably evacuate the bowels downwards;
and the most convenient form for
this purpose is a solution of emetic tartar. If
it should not have this effect, some brisk
purgative medicine should be given soon after
the operation of it.
I mention these evacuations before blood
letting; for though this ought to be first in
those cases in which it is proper, it is here
seldom necessary, and we may pronounce it
to be a remedy very ill adapted to this sort
of fever, particularly in a hot climate. It
sometimes happens, however, that there is
violent head-ach, pain of the back and limbs,
with a throbbing pulse; and these symptoms
may in the very beginning not only
justify, but require the losing some blood
before the administration of the emetic or
purgative.
The next means of relief I shall mention,
and also the most probable means of cutting
short the disease, is to excite universal
sweat. This being an imitation of nature,
is founded on reason as well as experience;
for it is by sweating that the fit of an intermittent
is relieved and terminated; and continued
fevers in general, if not always, begin
with a fit of the same kind. A dry skin,
accompanied with heat, is one of the most
constant as well as troublesome and uneasy
symptoms in all fevers; and it would appear
from the peculiar heat of the skin in this
sort of fever, that there is either a more
than common acrimony of the matter of
perspiration, or something peculiar in the
mode of circulation on the surface of the
body. Sweating does not seem to operate
entirely by the evacuation of acrimony, for
no relief is procured by it if it is partial;
and it is evident from a number of facts
that the state of the brain and viscera depends
on that of the external surface of the
body; for a free state of the pores of the
skin, provided it is general, tends more than
any other circumstance to relieve internal
pain, and also to take off delirium. The
good effect of sweating seems, therefore,
chiefly to depend on a general relaxed state
of the small vessels on the surface of the
body; and it ought to be effected, if possible,
by gentle, soothing means, and not by
such regimen and medicines as heat the body
and accelerate the circulation. This intention
is best answered in the beginning by moderate
doses of antimonial medicines, and
either James’s powder or tartar emetic may
be employed. The first is a more certain
sudorific, being less apt than the other to
run off by the bowels; and its effect will
be still more certain, if accompanied with a
mild opiate, rendered diaphoretic by Spiritus
Mindereri, which will both prevent the antimonial
from acting roughly, and will determine
its operation to the skin. A sweat
kept up by these means, together with plentiful
warm dilution, from twelve to twenty-four
hours, is the most probable means
of bringing about a complete remission of
the fever; and in this case a fresh accession
is to be prevented by the immediate administration
of the bark.
These are the means proper for stopping
the fever in the beginning, or tending to
render its future progress more safe; and
though, with this view, free evacuations
have been recommended, yet, if the fever
should go on, great caution is necessary in
this respect in the future treatment, debility
being the symptom chiefly to be guarded
against. Purgatives may, indeed, be occasionally
necessary, in consequence of accumulations
of bile taking place; but, in general,
the evacuations by stool should not
be more frequent than in health; and some
of the cases which were most unmanageable
and fatal, were those in which there was a
spontaneous diarrhœa. With regard to blood
letting, it is always hurtful after the first
two days, unless some inflammatory affection
of a vital part should arise.
The natural evacuation, which may with
most safety and advantage be solicited and
encouraged in this disease, is, that by perspiration;
and it is observable, that in those
cases for which nature does most, there is a
universal warm sweat, which has generally
a very offensive smell, and seems to be a salutary
effort of the constitution to cure the
disease. Where this takes place, little medical
assistance is necessary, except to keep
it up chiefly by warm dilution; and there
is no circumstance in which the judgement
of a physician is shewn more than in discerning
those cases in which his chief business
is to look on, where nature, being
equal to the task, ought not to be disturbed
by the active and officious interposition of
art. We should not, however, aim at producing
a profuse sweat, except with a view
to effect a remission immediately after the
first evacuations. In the course of the disease,
it is only necessary to keep up a gentle
moisture or softness of the skin.
The head being particularly affected in
this sort of fever, the patient is extremely
restless and delirious, especially at night;
and there is a medicine which has a most
pleasing effect in procuring both rest and
perspiration. This is a combination of an
opiate with an antimonial medicine, which
was administered in the evening with great
success; and the sudorific effect is rendered
more certain by the addition of some saline
neutral, especially Spiritus Mindereri92. I
tried pure opiates in the early stage of this,
fever, but found them not to answer;
though in the low93 fevers of England, and
in the advanced stages and convalescent state
of this fever, they are extremely safe and
useful. Pure laudanum is also given by Dr.
Lind, at Haslar, with great success in the
height of the disease; but in the West Indies
there is a greater tendency to acrid excretions,
and the effect of pure opium in
causing a retention of these, seems to be
the cause of its disagreeing in that climate
in the first stage of this fever.
It may here be observed, that the addition
of a little neutral salt alone will sometimes
so qualify the operation of opium, as
to prevent its bad effects, such as the increase
of febrile heat and delirium, and the
stupor and head-ach which, when given
alone, it frequently induces the following
day. I have generally employed nitre with
this intention; but this does not seem so
well adapted to this disease as some other
neutral salts, as it tends too much to lower
the powers of life.
But with a view to perspiration, the Spiritus
Mindereri is the most effectual neutral
medicine when conjoined with an opiate,
and there is not, perhaps, a more safe and
pleasing diaphoretic known than a combination
of it with syrup of poppies94. There
is some neutral salt in Dover’s powder, and
this has more effect than could be expected
from so small a quantity of an inert medicine;
for I know from trials of my own,
as well as those of others, that ipecacuanha
and opium given together, in the proportions
prescribed in that powder, will not
have the same effect as when joined with the
neutral salt. This is an instance of those
useful combinations of medicines which can
be discovered only by experience, but which
every physician ought gladly to adopt in
practice upon good testimony and fair trial,
though he may not be able to account for
their effects, nor to explain their mode of
operation.
There is nothing more important than
plentiful warm dilution; and the infusion of
sauge, or any such light aromatic, is rather
more proper than farinaceous decoctions, or
any compositions in which there is wine or
spirits. Success in this, as well as other
diseases, depends on attention to nursing as
much as upon medicine; for what would it
avail here to administer medicines for promoting
perspiration, unless they were assisted
with fluids to allay thirst, to dilute the
acrimony in the first passages and in the
vessels, and to furnish the materials of free
perspiration?
But however desirable it may be to procure
sweat, this is not to be attempted by close
rooms and bed clothes, nor by hot medicines,
such as volatile salts, serpentary, spirituous
tinctures, or aromatics. These, according
to the testimony of Sydenham, tend
to increase the heat and delirium, and to
produce petechiæ, miliary eruptions, or local
inflammations. In the intervals of the anodyne
diaphoretic above described, Spiritus
Mindereri and small doses of camphor, with
proper dilution, may be safely employed to
procure a soft skin.
The only other means I shall mention
with this view is, the application of warm
moisture to the surface of the body, which
may be done by soaking the feet and hands
in warm water, or by fomenting the feet
and legs with stupes95. These operations
have the effect of bringing on a general relaxation
on the skin, thereby taking off febrile
agitation and delirium, and inducing
sleep. I sometimes, with seeming benefit,
ordered cataplasms to be applied to the feet,
merely of the emollient kind, without mustard
or any other acrid substance, being intended
to relax, and not to stimulate.
In the use of pediluvia and fomentations,
there is a difference worth attending to between
the practice in this fever, and that in
the inflammatory fever before described, for
they are as hurtful in the latter as they are
beneficial in the former. I have observed,
in general, that they have a bad effect in all
cases where there is sizy blood, particularly
where the breast is affected.
Delirium is one of the most constant and
alarming symptoms in this disease, and the
removing of it depends much upon the attendants
as well as the physician. It has
been said before, that it depended on a false
apprehension of the impressions or natural
sensations. When a person, for example,
labours under delirium, and is affected with
thirst, the minds is either so agitated with
other objects, that this sensation is overlooked,
or, instead of producing a craving
for drink, it excites some other disagreeable
emotion in consequence of the disordered
state of sensorium. This last seems to
be probable from the cessation of delirium,
which will take place upon any natural want
being satisfied; I have seen a temporary
stop put to the patients raving by making
him drink, or upon his discharging his
urine or feces; for he is then unconscious
of thirst and other natural wants, is therefore
ignorant of the means of satisfying
them; and when he does so, he fancies he is
about something else which is the subject
of his delirious thoughts. This observation
leads to a material practical purpose; for it
follows from it, that unremitting attention
should be given to the patient’s feelings and
all his possible wants, as those natural notices
and instinctive cravings which occur in
health are now wanting, in consequence of
the depraved state of sensation.
Most of the remarks that have hitherto
been made apply to the earlier stages of the
disease. The principal remedies applicable
in the more advanced stages are, blisters,
Peruvian bark, opium, and wine.
I have found what Dr. Lind says concerning
the efficacy of blisters confirmed by my
own experience, especially in those fevers in
which there was great delirium, coma, and
head-ach; but I have not experience enough
to say whether they were as useful in the
beginning of the disease in the West Indies
as he found them to be in England.
The men that were brought from the
ships to the hospitals were affected with the
disease in various stages; but as we had in
general a very inaccurate history of the several
cases, the method of treatment upon
their first admission was pretty nearly the
same in all; and it consisted, in the first
place, in washing their face, hands, feet,
and legs, with warm water and vinegar,
from which they derived the greatest comfort,
being commonly very dirty. There
ought to be a 96warm bath at every naval hospital
kept in constant readiness; for there
are so few conveniences on board of a ship
for preserving bodily cleanliness among the
sick, that the surface of the body becomes
loaded with filth, so that the operation of
the warm bath could not fail to be highly
comfortable and salutary as the first step to
their cure when brought on shore. We had
generally very indistinct information about
the state of their bowels, as well as other
circumstances, on account of their delirium;
but it was at any rate useful, or at least
safe, to give them a clyster. They were
enjoined plentiful dilution; and if they
were low, some wine and water was allowed.
In the evening, the anodyne diaphoretic
medicine was administered, and a
blister applied to some part of the body. In
consequence of this method, we seldom failed
to find the patients better next morning;
and it was tried in such numbers, that the
efficacy of it was sufficiently ascertained. It
happened in some cases, that these means
were omitted, and a comparison of these
with the others served to ascertain the true
efficacy of the medicines; the stationary
state of the symptoms, when the disease
was thus left to itself, sufficiently proving
the propriety of the treatment above described.
It is an important question to what circumstances
of this fever the Peruvian bark
is adapted. An early and indiscriminate use
of it is recommended in some late publications,
upon the authority of which I tried
it without regard to the stages or symptoms,
and without any prejudice either for or
against the practice; but I found that this
powerful remedy was in danger of doing
much harm, unless great attention was paid
to circumstances, in order to ascertain the
proper seasons for giving it. The symptoms
that forbid the use of bark are chiefly
foul bowels, hard pulse, sizy blood, great
delirium, dry tongue, a hot and dry skin,
and inflammatory affections of the viscera.
It was found extremely pernicious in an
early stage of the disease previous to evacuations;
and the object of practice at this time
should be to relieve the habit by means of
these, in order to produce a general relaxation
of the secretions, and to render the skin
cool and soft, thereby paving the way for
the bark.
It is not necessary, however, especially in
the advanced stages of the disease in this
climate, to wait for an absolute remission,
in order to administer the bark. In a cold
or temperate climate it will seldom be found
advisable to give it in any period of this
fever; but in a hot climate it is sometimes
admissible where there are symptoms
of general debility, such as a small pulse
and muscular weakness, even though the
frequency of the pulse, delirium, and a dry
skin and tongue, should indicate some degree
of fever. It may be remarked, by the
bye, that a dry tongue is a fallacious symptom,
for it may happen in consequence of
the patient’s breathing through the mouth
instead of the nose, without any fault in the
secretions of the fauces. The symptom
which forbids the use of the bark more absolutely
than any other is an inflammatory
or dysenteric state of the bowels, in which
cases it seems to be invariably pernicious.
Where it happens that we are extremely
anxious to throw in the bark, as we usually
are in the West Indies, where fevers are
very rapid and dangerous, and yet the
symptoms seem hardly to admit its use, it
was very commonly tried either in conjunction
with some antimonial medicine or neutral
salt, or these were given alternately
with it, in order to soften and qualify its
effects by preventing it from heating or
otherwise aggravating the symptoms. Antimonial
wine or Spiritus Mindereri were conveniently
employed with this intention.
With regard to the quantity of bark to be
given, it may be proper in doubtful cases of
this kind to begin with small doses, in order
to feel how far it agrees or not; but in general
it may be laid down as a rule with regard
to this medicine, that, where it is
really proper, and the medicine to be depended
on, it is to be given in as large doses
and as frequently as the stomach will easily
bear it.
The next remedy mentioned was opium.
It is a medicine more admissible and useful
in this than any other kind of fever. The
same cautions nearly apply in the administration
of it as have been given with regard
to the Peruvian bark. The caution with
regard to foul bowels is particularly necessary
in a hot climate, where an over secretion
of bile is so apt to take place. When,
the Boreas frigate arrived from England in
March, 1783, there was a very bad fever of
the infectious kind on board, some cases of
which being sent to the hospital at St. Lucia,
were treated unsuccessfully with bark
and opium, which I had been induced to
try upon the authority of the authors above
alluded to. I attributed this want of success
to the neglect of previous evacuation;
for, upon inspecting the bodies, the intestines
were found full of bilious feces. I profited
from this, and was more successful in the
other cases. It were to be wished that physicians
could oftener bring themselves to confess
their errors in practice, and their writings
would be more instructive; for it is of
consequence to know what we are to avoid
as well as what we are to follow.
It has been mentioned that the best effects
arise from the conjunction of an antimonial
with an opiate; but, in this sort of fever,
antimonials, and even most of the neutral
salts, are hurtful after the first stage, and
opiates may after this be given alone or
combined with camphor. With regard to
the precise period of leaving off antimonials,
it must be left to discretion, and the constitution
of the patient is the best guide.
There is so great a difference in patients in
this respect, that all practical precepts should
be qualified by a due discrimination of constitutions.
Absolute and dogmatical rules
are so far from applying in the practice of
physic, that there are some cases of the
same disease that require a treatment even
opposite to what is in general most adviseable.
This may be very aptly illustrated
by the small pox, of which there are cases
that ought to be treated very differently from
the general method laid down by Sydenham,
and in which cordial medicines are highly
proper and necessary. This difference in
diseases themselves seems to be one great
cause of the difference of opinion among
physicians on practical points, each party
finding some countenance in experience for
their general doctrine, do not make allowance
for the varieties that exist in nature;
so that, in one sense, both may be said to be
in the right. If the patient is not very
much sunk, and if there are bilious symptoms,
or an obstinate dryness in the skin, a
few grains of James’s powder may be given
with advantage even in an advanced period
of the disease. If a hot and dry skin should
at this period be the only troublesome symptom,
it will be more safely and effectually
removed by camphor combined with something
opiate and the Spiritus Mindereri, which
is the only neutral now admissible, than by
antimonials, which, at this time, would be
in danger either of ruffling the patient by
their operation on his stomach and bowels,
or of weakening him too much either in
this way, or by exciting profuse sweats.
Evacuant medicines of every kind being
then improper, clysters are the only laxatives
to be employed in case the state of the
bowels require them.
Having mentioned camphor, it may be
proper here to remark, that it is a medicine
of which I have found it extremely difficult
to ascertain the virtues and effects; and in
consequence of this ambiguity, I believe
there are few articles of the materia medica
more abused in practice. In all inflammatory
affections, and in the beginning of all
fevers where there is much heat and thirst,
I think I have observed it to aggravate the
symptoms. It seems in no case to be more
proper than at certain periods of this fever,
and especially when there happens to be
spasmodic pains of the stomach, or tremors
and cramps in the extremities.
In this advanced stage of the fever, in
which the most common symptoms are weakness,
restlessness, tremors, and low delirium,
no medicine was found so much to be trusted
to as opium, which here acts as a cordial as
well as an anodyne and antispasmodic. It
may be given, in the camphorated julep, in
the form of tincture, from five to ten drops
every six or eight hours, or some of the officinal
compounds, such as the theriaca or
mithridate, may be employed with advantage.
I have thought also, that, at this period,
castor conjoined with opium seemed to
improve its virtue. This was first suggested
to me by Mr. Crudie, an ingenious German
surgeon, whom I employed as an assistant at
the hospital at St. Lucia; and since I have
been physician to St. Thomas’s hospital, I
have found the most pleasing effects, in similar
cases, from a composition used there,
the principal ingredients of which are opium
and castor97.
In this state of the fever I have also used
with advantage the decoction of Peruvian
bark and serpentary, as recommended by
Sir John Pringle; and when the skin is cold
and the circulation is very languid, as is
sometimes the case, volatile salts and powder
of serpentary may very properly be employed.
But in the advanced state, and in the
worst forms of this disease, there is perhaps
no medicine superior to wine. This was
given either pure, or diluted with water for
common drink, and sometimes to the quantity
of a quart in twenty-four hours. In
delicate people, such as we meet with in
private practice, the quantity ought to be
less.
There is this caution necessary with regard
to the use of wine, that when the fever
is gone off, and only extreme debility remains,
the free use of it is not safe nor proper;
for, in a weak and exhausted state, a
person is more apt to be 98heated and intoxicated
by any fermented liquor, than in
health, or even in the preternatural and disturbed
state of actual disease, such as occurs
in this fever.
After the disease is removed, a long state
of weakness is apt to succeed, especially in
a warm climate. The most proper remedies,
then, are bitters, such as decoctions of Peruvian
bark, infusions of quassia bark, gentian,
or camomile flowers. These answer
better than the bark in substance, which is
now apt to nauseate and load the stomach,
and the patient is apt to take an aversion to
this and whatever else he took in a state of
sickness. The best strengthening medicines
are such as comfort the stomach and create
appetite; and we may mention Huxham’s
tincture of bark, in small doses, and a moderate
use of wine, as the most proper for
these purposes. Where colliquative sweats
take place, elixir of vitriol is serviceable,
and with this intention I have joined it,
with evident advantage, to the evening anodyne,
which, without such a corrector, tends
rather to aggravate this symptom. I have
known assafœtida prove a useful stimulus to
the stomach at this time, and it may even
be used while the fever subsists, especially
where the secretions of the fauces are scanty.
This medicine is recommended by Sir John
Pringle in the same circumstances. But I
consider the prudent use of opiates, particularly
at bedtime, as the most effectual cordial
and strengthening medicine in this convalescent
state.
But with regard to the management of
the sick at this time, as much depends on
diet as medicine. Nothing has been said
concerning this in the acute state of fever,
because no nourishment is then necessary.
In that state there is a loathing of all food,
and the powers of digestion and assimilation
seem to be then suspended, so that alimentary
substances become not only an useless
load, but offensive and hurtful by turning
acid or putrid. It is likewise evident from
fact, as well as reason, that nature, in this
situation, does not require sustenance; for
we frequently see people labouring under
fevers who do well and recover, though
they have been entirely without nourishment
for a length of time in which the like abstinence
in a state of health would have
proved fatal. The friends and attendants
of the sick, from a prejudice not unnatural,
but not considering the difference between
health and that state of derangement which
takes place in fever, are for ever wishing to
supply the patient with nourishment, and
every physician meets with trouble in counteracting
this officiousness. Nevertheless,
when the fever draws out to a considerable
length, and the principal symptom is that
state of weakness which, in low fevers, runs
insensibly into that of convalescence, then
it is necessary to pay the utmost attention
to nourishment, and nothing tends more to
insure and hasten recovery than the assiduous
administration of light and nourishing
food, the same cautions being observed which
have just been mentioned with regard to
cordials. One of the greatest hardships of
a sea life is the want of those articles of diet
that are suitable to a recovering state, and
many lives are lost from this circumstance,
after the force of the disease has been subdued99.
With regard to the peculiar form, before
described100, which this fever assumes a few
months after ships have been in a hot climate,
we found camphor, volatile salts, and serpentary,
the best remedies. As there was a
remarkable coldness of the skin, I was induced
in one case to try the hot bath, and
with good effect, from which it seems probable
that a short stay in a bath, of a heat
from 96° to 100°, so as to have its warming
and stimulating, without its relaxing
effects, would answer well in fevers of this
kind.
This is peculiar to tropical climates,
and arises in the same situations in which
intermitting fevers arise in temperate and
cold climates. It seldom arises at sea, unless
where there has been previous exposure
on shore, of which some examples have
been mentioned in the first part of the work.
It may generally be traced to the air of
woods or marshes; and in our fleet hardly
any men were attacked with it but those
who were employed in the duties of wooding
and watering.
The most distinguishing symptom is a copious
secretion of bile which attends it. Its
course, in general, is shorter than that of
the fever before described; and though the
symptoms are more violent, they are not so
equal and steady, owing to the tendency
there is to remission. The symptoms are
particularly violent at the beginning, in so
much that some of the men, after being exposed
upon duty to the heat of the sun and
the air of marshes and woods, would become
frantic, being seized almost instantaneously
with delirium resembling madness.
This fever, when it arises merely from the
effluvia of woods and marshes, has a natural
tendency to remit; nay, some fevers at St.
Lucia, proceeding from this cause, were of
the pure intermitting form from the beginning.
But in many of those that arose at
Jamaica little or no remission was to be perceived;
and it was distinguished from the
ship fever by the bilious vomits and stools,
more violent delirium, and head-ach, and
by being attended with less debility. The
greater tendency to the continued form at
this time was probably owing to this circumstance,
that the men who were exposed
to the land air in wooding and watering,
were then exposed also to such causes as
naturally produce continued fevers, such as
infection, the foul air of the French prizes,
intemperance, and hard labour. There was
in some cases a yellowness of the eye, and
even of the whole skin, but without the
other symptoms that characterise the yellow
fever, properly so called.
In cases that proved fatal, the symptoms,
for some time before death, resembled very
much those of the fever before described at
the same stage. There was either coma or
constant delirium, great seeming anguish,
the mouth and tongue very dry, or with
only a little ropy slime, a black crust on the
teeth, picking of the clothes, and involuntary
stools.
The measures proper to be taken in the
beginning of all fevers are pretty nearly
the same. There is little difference in
the first treatment of this from that of the
ship fever, except that blood letting is here
more frequently proper, and that a more
free evacuation of the bowels is necessary
on account of the more copious secretion of
bile.
In full and athletic habits the disease very
commonly begins with pains in the limbs,
back, and head, with a strong throbbing
pulse; in which case it is proper first of all
to let blood at the arm. This is also highly
proper and necessary in those cases mentioned
above, in which the patient becomes suddenly
frantic. But though the cases requiring
blood-letting are more frequent in this
sort of fever than that already treated of,
yet great caution and nice discernment are
necessary with regard to it, in all cases, in a
hot climate. As fevers in such a climate
run their course faster, the symptoms succeeding
each other in a more close and hurried
manner, greater expedition, as well as
discernment, are required in timing the different
remedies than what are necessary in a
cold climate. Blood letting unseasonably
and injudiciously employed either endangers
life, or has a very remarkable effect in protracting
recovery, by the irrecoverable weakness
it induces.
With regard to the evacuation by the
bowels, it has already been mentioned in
another part of the work, when on the subject
of prevention, that, before the fever
comes on, there is a languor and general
feeling of indisposition, and that then an
emetic and a purgative, followed by some
doses of the bark, were the most likely
means of preventing the attack of the disease.
If the fever has properly begun, which
is announced by a rigor taking place, then
no time is to be lost in procuring evacuation;
and, after blood letting, if the symptoms
should require it, the best medicine is tartar
emetic, which, if given in small divided
doses, at short intervals, will most probably
evacuate the whole intestines by vomiting
and purging, and may even prove sudorific.
But it will nevertheless be proper to administer
a purgative medicine soon after; and
what we found to operate with most ease,
expedition, and effect, was, a solution of
purging salts and manna, either in an infusion
of sena, or in common water, or barley
water, with some tincture of sena added
to it.
The next step towards procuring a remission
is, to open the pores of the skin,
which is best done by small doses of James’s
powder or emetic tartar, assisted by the common
saline draughts, which will be given
with most advantage in the act of effervescence,
or by Spiritus Mindereri, together
with plentiful warm dilution. I once, by
way of comparison, tried the two antimonial
preparations above mentioned in a number
of men ill of this fever, who were sent
to the hospital at one time, giving emetic
tartar to one half, and James’s powder to
the other, and their effects were so similar,
that I could perceive no reason for preferring
the one to the other. Antimonial medicines
seem better adapted to this than any
other sort of fever, and may be more freely
given in it.
These are the most likely means of bringing
about a remission; and if this is effected,
nothing remains to be done but to throw in
as much Peruvian bark as the stomach will
bear.
But whether from a fresh accumulation
of bile, or some other circumstance, it may
happen that the fever is kept up; and in
this case there is commonly a sense of weight
or uneasiness about the hypochondria, which
seems to indicate that the redundant bile is
in the gall bladder or ducts of the liver. In
this case a repetition of evacuants is necessary,
and calomel will be found to answer
remarkably well as a purgative, its stimulus
being so extensive as to loosen and bring
away bile when the saline purgatives, such
as that above mentioned, had failed of having
that effect. I have known these to
pass through the intestines without relieving
the uneasy sensation about the stomach as
calomel is found to do; and it will be still
more effectual for this purpose, if given alone
in a dose, from five to ten grains, and followed
some hours afterwards by some other
purgative. After this, antimonial medicines
are again to be had recourse to; and these,
as well as purgative and neutral medicines,
are safe and useful in a more advanced stage
of this fever than they are in the ship fever;
for the strength is not so apt to sink, and
the state of the bowels requires them more.
Antimonials, however, are to be used sparingly
and cautiously as the fever advances;
for I have known them, when given only a
few days after the first attack, to have the
effect, in some constitutions, of making the
stomach swell, and of producing a general
sense of heat and uneasiness.
After the evacuations of the bowels, the
anodyne diaphoretic may be very seasonably
given in the manner formerly mentioned;
for it will not only tend to sooth and procure
sleep after the commotion that has been
excited, but by its gentle sudorific effect will
assist in completing the remission.
The principal point of management in
the fevers of this climate is, to throw in
the Peruvian bark in proper season. I formerly
took occasion to differ from the opinion
of those who alledge that little or no
discrimination is necessary with regard to
the circumstances in which bark is proper
in continued fevers. I made fair and unprejudiced
trials of this, but always found that
some sort of remission, especially towards
the beginning of the disease, was necessary,
in order to make the use of this medicine
safe and proper. The greatest vigilance is
indeed required that the administration of it
be not omitted when it is at all adviseable,
as the course of fevers is very quick and
critical in this climate. I have watched
many nights with some friends in whose
health I was particularly interested, to catch
the hour when it might be allowable to give
it; and where the propriety of it was somewhat
ambiguous, it was usual to qualify it
either by conjoining some antimonial or neutral
salt with the first doses, or by giving
them alternately with it, as has been formerly
mentioned.
Under the use of these means, the favourable
symptoms are, a warm moist skin, a
strong steady pulse, with the pulsations under
a hundred in a minute, a natural countenance,
and being free from delirium. But
if the fever should not yield during the first
week, but takes an unfavourable turn, the
pulse then becomes more small and frequent,
there is a general agitation, the tongue is
tremulous when put out, there is great thirst
and delirium, with a dry and hot skin. In
these circumstances, besides the continuation
of the antimonials in smaller doses,
with the anodyne diaphoretic, and the occasional
use of purgatives, blisters now become
proper; and we found also camphor combined
with nitre an excellent medicine at
this period of the disease.
Should the patient survive to the end of
the second week, the treatment then comes
to resemble more and more that of the infectious
fever already described. Bark may
be given, though there should be no proper
remission, and cordials and opiates may be
more freely used. Attention to the state of
the bowels will still be necessary, since repeated
accumulations of bile are apt to occur
even in the most advanced stage, and
gentle emetics of ipecacuana, as well as
laxatives, may be necessary. For the same
reason also, greater caution is requisite in
the use of pure opiates than in the infectious
ship fever before treated of. In order to
keep the bowels soluble, it was a very usual
practice, and found very useful, to conjoin
a few grains of rhubarb with each dose of
the bark.
The fever last treated of may be said to
be peculiar to a hot climate; but the hot
seasons of temperate climates produce something
resembling it. That now to be described
never occurs, so far as I know, except
under the influence of tropical heats.
Such a fever is indeed known without the
tropics; for it is very common in Carolina
in the hot season; but there the heat is
even greater than that of the West Indies.
In order to produce it, there must be, for
some length of time, a heat seldom falling
below seventy-five degrees on Fahrenheit’s
thermometer.
Though it differs from the fever last described,
both in its causes and symptoms, it
is not meant to say that it is so distinct as to
form a separate species of disease, like the
measles and small pox. Unless the characters
of fevers are strongly marked, it is difficult,
and even impossible, to refer them to
any particular species; and the different concurrence
of causes and constitutions is so
various, that great numbers of ambiguous
cases occur.
With regard to the cause of the yellow
fever, it differs from the bilious remittent
in this, that the air of woods and marshes
is not necessary to produce it; for it most
commonly arose from intemperance or too
much exercise in the heat of the sun. It
was observable, however, that it was more
apt to arise when, besides these causes, men
were exposed to unwholesome air, particularly
the foul air of ships, whether from infectious
effluvia, or proceeding merely from
the putrefaction that takes place in neglected
holds.
It is also remarkable with regard to it,
that it is confined almost entirely to those
who are newly come from a cold or temperate
climate. The same remark is made by
the French, who therefore call it fievre de
matelot101, considering it as peculiarly incident
to those who have newly arrived from a long
voyage. It would appear also, from what
has been formerly mentioned102 that those
men, who have been exposed to that sort of
infection that prevails in ships in cold climates
are more particularly the subjects of
the yellow fever when they arrive in a hot
climate. It is farther in proof of the same
opinion, that there are medical gentlemen,
natives of the West Indies, who have hardly
ever seen it, their practice lying at a distance
from any sea-port town where strangers
usually arrive. Of these strangers, those
who are young, fat, and plethoric, are most
apt to be attacked; and more of our officers
in proportion were seized with it than common
men.
It has been said, that it never attacks either
the female sex or blacks. This is in
general, though not absolutely, true; for I
knew a black woman, who acted as nurse to
some men ill of this fever at Barbadoes,
who died with every symptom of it.
This fever assumes various forms, according
to the peculiar constitutions of different
men, and other circumstances; but in the
following description I shall enumerate the
most common appearances:—In general it
begins with short alternate chills and flushes
of heat, seldom with those rigors which
constitute the regular cold fit, and with
which most other fevers begin. These are
immediately succeeded by violent head-ach,
pain in the back, universal debility, sickness,
and anguish at the stomach. There is
commonly, in the beginning, a good deal of
bile on the stomach, which is thrown off
by vomiting, either natural or excited by
an emetic. Those men who were taken ill
of this fever in the Alcide, in the end of
the year 1781, had a sore throat in the beginning;
but this is not a common symptom.
In the course of this disease there is by
no means a free secretion of bile, and least
of all in those cases that are most violent,
and prove the soonest fatal. In cases that
are more protracted, and less desperate, there
are frequent accumulations of it, as appears
by the vomits and stools103.
The eye in a few hours takes a yellow
tinge, which soon after extends more or less
over the face and whole skin. This is a
symptom so striking and constant, that it
gives name to the disease, though it is not
absolutely either peculiar or essential to it.
There is something contagious in this symptom,
which seems somewhat singular, and
difficult to be accounted for. It was observed
in the Royal Oak and Alcide to extend
to men who were but slightly indisposed;
and at the hospital it spread to men
in the adjoining beds, without imparting
any malignity to their diseases.
There is something very peculiar in the
countenances of those who are seized with
it, discernible from the beginning by those
who are accustomed to see it. This appearance
consists in a yellow or dingy flushing
or fullness of the face and neck, particularly
about the parotid glands, where the
yellow colour of the skin is commonly first
perceived. There is also in the eye and
muscles of the countenance a remarkable
expression of dejection and distress.
One of the most constant and distinguishing
symptoms of this fever is an obstinate,
unremitting, and painful pervigilium, which
is the more tormenting, as the patient is
extremely desirous of sleep. It is seldom
that even a delirium comes to his relief to
make him forget himself for a moment;
but he continues broad awake, night and
day, with his reason and senses sound, in a
state of the most uneasy agitation.
But the most distinguishing symptom, and
that which is expressive of the greatest danger,
is, an unconquerable irritability in the
stomach, which can be brought to bear nothing.
An almost incessant retching takes
place, which commonly, on the third day,
ends in what is called the black vomit, the
most hopeless of all the symptoms attending
it. When this is examined, the colour is
found to be owing to small dark flakes, resembling
the grounds of coffee, and seems
to be blood which had oozed from the surface
of the stomach, a little altered. Indeed
pure blood is sometimes thrown up, and we
know that the red globules enter the smaller
order of vessels, and issue by them; for
bleeding at the nose is a common symptom
about this time; and some relate that it also
escapes by the ears and pores of the skin,
which I never saw, but can readily believe
it. At the same time, the stools grow
black, and the urine is frequently of a very
dark colour, which seem to be owing to
the same cause. I never remember to have
seen any one recover after these symptoms
came on.
There seems to be a general error loci of
the more tenacious and globular parts of the
blood into the smaller order of vessels, to
which the yellow colour is in a great measure
owing; and when any part of the skin
is ever so little pressed upon, a damask red
colour remains for some time, the small
vessels readily admitting the red globules.
It is certain that a yellow colour of the skin
may be produced by such an error loci, without
any suspicion of the presence of bile.
We have an illustration of this in the ecchymosis
which follows upon an external
contusion. In this case the red part of the
blood is mechanically forced either into the
smaller order of vessels, or into the cellular
membrane, which occasions a livid appearance,
and in the course of the recovery the
same parts become yellow, probably in consequence
of some of the gluten of the blood
assuming this colour after the red parts have
been removed by absorption or otherwise.
In the worst form of this disease there is
all along an uncommonly distressing sensation
of universal anguish, particularly about
the stomach, where there is a sense of
burning heat, which, as the miserable sufferers
themselves express it, becomes unspeakable
torture.
A sense of weight at the breast, deep and
frequent sighing, and a great failure of muscular
strength, are dangerous symptoms in
all stages of the disease.
Upon the first attack the skin is extremely
hot and dry, and the pulse hard and frequent;
but the external heat soon becomes
very little different from the usual standard
of health, and the skin feels soft and moist.
There sometimes happens an eruption of
small pustules, with white heads, on the
trunk of the body, which is a favourable
sign; and I have seen a head-ach disappear
upon this breaking out. The pulse does not
serve as an index of danger; for, after the
hurry of the first attack, it becomes very
moderate in point of frequency, varying
from eighty to a hundred pulsations in a minute,
and is natural in point of regularity
and strength.
In these circumstances this fever differs
from that which was last described; and it
also differs from it in being attended with
little delirium. I have seen cases in which
the senses were not affected from beginning
to end; and I never observed that violent
and incessant delirium which attends other
dangerous fevers.
The state of the fauces is also different
from that of most other fevers, for there
is no excessive thirst. The tongue is somewhat
white and foul; but I do not remember
ever to have seen it black and dry.
A want of action in the bowels, and an
insensibility to purgative medicines, indicate
great danger; and, next to the black slimy
stools, one of the most unfavourable symptoms
is, when the feces are like white clay,
as I have seen in some cases that ran out to
the length of a week before they proved fatal.
When the black vomit and stools occur,
death commonly happens on the third
or fourth day. A bilious diarrhœa spontaneously
coming on, is a very favourable symptom.
In more unpromising cases the urine is
scanty, and in the last stage of life it becomes
of a very dark colour, as was mentioned
before. A plentiful secretion of urine
is a very favourable circumstance, and seems
to be one of nature’s methods of curing the
disease; for such cases are observed to terminate
well. I remember one case in particular
in which several quarts were made
daily for several days together, and it was of
a very dark saffron colour, but looked green
where the surface was in contact with the
side of the pot. I inspissated a small quantity
of it, and found a large residuum,
which was very deliquescent, and seemed
to be all saline. In a hot climate the urine
does not shew that separation and deposition
which denote the crisis of fevers in cold climates,
and this is perhaps owing to there
being less mucilage and more alkali in the
former, on account of the more putrescent
state of the fluids. Upon adding a little
vinegar to the urine in the case above mentioned,
it became turbid like the critical
urine of the fevers of Europe.
At the approach of death, cold clammy
sweats come on; the pulse continues regular
and of a certain degree of strength, but
grows gradually slower. I have counted it
at forty pulsations in a minute. The patient
is frequently sensible to the last moment;
nor does the countenance sink into what is
called the Hippocratic appearance. In other
cases I have seen, at this time, coma, and
not infrequently convulsions. Broad livid
spots sometimes also appear on the skin.
Extreme muscular debility, a great difficulty
of deglutition, and a dimness of the
eye-sight, are likewise common symptoms
in the last scene.
The different stages which lead to dissolution
following each other thus rapidly, there
is not that gradual failure of the powers of
nature that usually give warning of approaching
death; but the springs of life run
down, as it were, at once, the wretched
sufferer expires, and is happily delivered
from the most extreme misery of which
human nature is capable.
Such is the general train of symptoms in
this fever, taken entirely from my own observation;
but great varieties occur both in
the symptoms and duration, so great indeed,
that it is hardly recognisable for the same
disease. I shall give specimens of such anomalous
cases in two that occurred at Port
Royal, on board of the Canada, in July,
1782.
A lieutenant of that ship had been subject,
for four days, to fits of retching, without
any bilious discharge or pain in the stomach;
and, except a white tongue, he had no
symptom of fever in that time, nor any
thing to prevent him from doing his duty.
On the fourth day, when I first saw him,
he began to complain of a fixed pain in the
pit of the stomach, which was not very
violent, and about the same time a yellowness
began to appear on the white of the
eye. He took a laxative medicine, which
had the desired effect, and some volatile spirits,
with some drops of thebaic tincture in
simple mint water, for the pain in his stomach.
He had a good night. Next day
the complaint of the stomach was better;
but there was great muscular debility. He
had several natural stools; and as there seemed
little indication but debility, he took nothing
that day except an infusion of some
bitters and aromatics in wine. As he did
not want for appetite, he eat some broth
and chicken; and nothing to give any alarm
happened this day, except a short qualm,
in which he was faint, with a sense of cold,
feeling to himself, as he said, as if he
should have expired. In the afternoon he
began to have black-coloured stools, which
was the first symptom that clearly betrayed
the nature of the disease. He was then ordered
as much Peruvian bark as he could
take with red wine, and these his stomach
bore. Decoction of bark was also given
him in clysters. He had a strong voice,
and was quite sensible, but grew weaker
and weaker with frequent returns of the
qualms, and he expired that evening before
ten o’clock.
I have not the least hesitation in ranking
this case with the fevers last described,
though so many of the usual symptoms were
wanting. This gentleman, though of a
lively, active disposition, was of a slender
make, and of a dingy, doughy complection,
and his case gave me the idea of a disease attacking
a constitution which, not having
powers to struggle with it, is overwhelmed
without making resistance105. In those robust,
plethoric habits, which are most commonly
attacked, there is a sufficient degree
of strength to excite the violent symptoms
before enumerated.
A few days after this gentleman’s death,
another officer of the same ship was taken ill
with the same sort of fever, and it was also
attended with several unusual symptoms.
Neither his skin nor eyes were yellow; the
skin was hot and dry throughout the disease,
and during the three first days there
was a diarrhœa, which was neither bilious,
putrid, nor mucous, but consisted in watery
stools. There were no gripes, nor any
local pains whatever; but I never remember
to have seen more suffering from that
general anguish, particularly about the stomach,
which attends this sort of fever. On
the third night he began to vomit and purge
blood, which soon terminated in that dark-coloured
discharge which is a symptom so
characteristic and fatal in this disease. He
continued sensible till within eight hours of
his death, which happened on the fourth
night. The pulse was full and pretty
strong during the whole course of the disease;
but there was all along great debility
and frequent sighing, symptoms that ought
always to create alarm.
I feel this as the most painful and
discouraging part of this work, the yellow
fever being one of the most fatal diseases to
which the human body is subject, and in
which human art is the most unavailing.
It seems hardly to admit of a doubt that
there are particular instances of disease, in
their own nature, determinedly fatal, that is,
in which the animal functions are from the
beginning so deranged, that there are no
possible means in nature capable of controlling
that series of morbid motions which
lead to dissolution. Of this kind appear to
be the greatest number of cases of the
plague, many of the malignant small pox,
and some of fevers, particularly of that kind
now under consideration. It is extremely
difficult to ascertain such cases from observation;
and it may be said that the opinion
of the existence of them is favourable to
ignorance and indolence. But, on the other
hand, it may be questioned if more harm is
not likely to arise in medicine by being too
sanguine and officious, than by a diffidence
of art and trusting to the powers of unassisted
nature? Were we thoroughly acquainted
with the animal œconomy, we should perceive
à priori in what instances the seeds of
disease would either operate so as necessarily
to terminate in death, or when they were
within the command of art. But we can
derive little or no information from this
source, on account of our great ignorance
of the secret operations of the living body;
so that the only grounds of judging are our
observation and experience concerning the
usual event of disease, and the effects of remedies.
Though these are circumstances
attended with great uncertainty and ambiguity,
yet I believe it will be admitted as
the opinion of the most chaste and experienced
observers, that there do really exist
diseases whose course cannot be diverted by
any means that can be employed. This
opinion, I have said, is, in one view, extremely
discouraging; yet, to the mind of
a feeling and conscientious practitioner, who
must often find his best endeavours baffled
in many diseases as well as this, and who
might be apt to look back and accuse himself
of some fault or omission, it affords
this satisfaction to his reflections, that the
want of success may have been owing to
something in the nature of the disease, and
not to his want of skill and attention.
But though the fatality of this disease is
discouraging, let us not despond, but rather
redouble our diligence in observing what assistance
and relief nature may admit of.
It is proper in this as in every other fever
of this climate, to begin the cure by cleansing
the first passages. This does not produce
the same relief as in the common bilious
fever, probably because there is a less
free secretion of bile, and therefore less oppression
from the collection of it.
With regard to blood-letting, the most
that can be said in its favour is, that if
there should be a hard throbbing pulse, with
violent pain in the head and back, it is safe
in the first twelve hours. This limitation
is necessary, at least with regard to common
seamen, who do not bear evacuations so well
as officers and others, who are used to a better
diet, and to whom the loss of blood has,
in some cases, been found useful in the
early stage of this fever. It is, however, in
all cases extremely dangerous, except in the
circumstances mentioned above. The blood
is said to shew a buff in the beginning of the
disease, but in the second stage, it is mentioned
by a French author106, that it hardly
coagulates or separates. But even the appearance
of a buff, without considering other
circumstances, does not always argue the
propriety of blood-letting107.
The great object in the cure of this fever
is, to bring the stomach to bear the bark.
There are here wanting most of the circumstances
that in the other cases forbid the
use of it; for there is no preternatural
quantity of bile in the stomach and intestines,
nor is there a hot and dry skin, nor
violent delirium. The only obstacle to its
administration is the great irritability of the
stomach, which is the most fatal symptom
of the disease; and the principal part of the
management of the patient consists in the
prevention or removal of this. The stomach
is to be treated with the utmost tenderness
and attention. One gentle emetic
at the beginning is all that is allowable;
and as fresh collections of bile are less apt to
occur, the repetition of it is less necessary.
It is best to abstain altogether from antimonial
medicines, and to render every thing,
whether food, drink, or medicine, as grateful
as possible. The liquid most apt to stay
upon the stomach is the juice of the acid
fruits of the climate, such as108 oranges and
lemons. It happens frequently, however,
that acids come to be loathed extremely, so
as to nauseate the stomach and to encourage
retching. In this case I have found a composition
of wine and water with lemon juice
and nutmeg, sweetened with sugar, and given
warm, to be a very grateful and salutary
drink. The patient sometimes prefers the
decoction of farinaceous substances to every
other liquid; and in one case in particular,
which did well, the patient was led by taste
to prefer warm water gruel to every thing
else, and the great quantity he drank seemed
to have a considerable share in his recovery,
by keeping up a warm moist skin and producing
a great flow of urine.
In order to check vomiting, the saline
draught, in the act of effervescence, has been
employed with evident advantage; but in
most cases this symptom is so obstinate as
to discourage all attempts to remove it. I
have known magnesia in mint water have a
visible effect in soothing the stomach, particularly
when given immediately after some
acid beverage.
I was informed by Dr. Young, physician
to the army, that he found an infusion of
chamæmile flowers one of the best medicines
in this vomiting; and a surgeon of one of
the line-of-battle ships informed me, that he
also found advantage from it in alleviating
this symptom. The French author above
mentioned affirms, that milk, boiled with
some flour or bread, given in the quantity
of a spoonful at a time, and frequently repeated,
had more effect than any thing he
tried in stopping the vomiting in this fever.
I have seen this symptom relieved by fomenting
the stomach with stupes wrung
from the decoction of bark, and sprinkled
with camphorated spirits and tincture of
bark109.
But nothing I have ever seen tried had so
great an effect in removing this irritability
of stomach as a blister applied to it externally;
and it is a remedy which, so
far as I know, has not been hitherto recommended.
In other fevers, when the
head was not particularly affected, I preferred
this part for the application of a blister,
for it is in some respects more convenient
than between the shoulders, and the
stomach is the part more affected perhaps
than any other in all fevers. But in this
fever I was led to apply it to this part, both
from its being affected in an uncommon degree,
and from observing, upon inspecting
the bodies of those who died, that the only
morbid appearance that could be discovered
was an inflammatory suffusion on the inner
membranes of the stomach.
I have employed opiates both externally
and internally to allay this symptom, but
without the effect that might have been expected
from so powerful a sedative.
As the stomach will seldom, even in the
most favourable cases, bear such a quantity
of bark as to subdue the disease, it must be
exhibited in every other way that can be
thought of, such as by clyster and by external
fomentation, both of which I have
employed with good effect. I used to order
a pint of decoction of bark to be injected
every three or four hours, and the fomentation
to be employed nearly as often. I have
heard of the decoction of bark being used as
a warm bath with success; but I cannot
decide concerning this practice from my
own experience.
I have no other internal remedy to recommend;
for whatever power of retention the
stomach may have should be employed in
taking bark. If it should become tolerably
retentive, camphor will be found of service;
and if given in the evening with an
opiate, perspiration and sleep will probably
be procured, by which the patient will be
greatly relieved.
Blisters to the thighs and legs seemed to
coincide with the general intention of cure,
and they appeared to be of advantage in the
cases in which they were tried.
It frequently happens in the West Indies
that intermittent fevers are so obstinate
as to resist the common means of cure by
the Peruvian bark; so that these complaints
become extremely distressing to the medical
practitioner as well as to the patient. Indeed
this was a difficulty that occurred so
often, that I was sometimes tempted to
think, either that the great reputation of
this medicine is not so well founded as is
commonly believed, or that the bark generally
in use in these times is not of so good
a quality as that employed by the physicians
who first established its character.
But, in the first place, the experience upon
which its reputation was first built was in a
temperate climate, where very few agues
are found to resist it when properly administered.
In the next place, there is reason to
believe that, in fact, the medicine itself now
commonly in use is not equally powerful
with what was first employed; and a species
of it, called the Red Peruvian Bark,
has lately been discovered, or rather, perhaps,
revived, which is certainly of a superior
quality, and has been found to cure intermittents
in which the common sort had
failed110.
However this may be, it is an undoubted
fact that obstinate agues are much more frequent
in the West Indies than in Europe;
and something to supply the insufficiency of
the bark seemed to be a desideratum.
I was informed by Dr. Hendy, of Barbadoes,
that he had found the flowers of zinc
to answer in cases of intermittent fever, in
which even the bark and every other remedy
and mode of treatment had failed. It was
found very successful in the like cases, both
in my own trials at the hospitals, and by
the surgeons of the men of war to whom I
recommended the use of it. In order to
judge what may be expected from it, I shall
give a specimen of its success in some cases,
at the hospital at St. Lucia, of which I kept
an accurate account, in the months of February
and March, 1783.
About the time the fleet arrived there,
six cases of intermittent fevers were sent to
the hospital from different ships. One was
of six weeks continuance, and had been
some times of the tertian, sometimes of the
quartan type. Two were quartans; one of
which was of two months, the other of
eight months duration. Two were regular
tertians; of which one had only had two
fits, but was a relapse after a week’s exemption
from an attack of several weeks. The
other was of three months continuance, attended
with an eruption on the hands and
arms. The sixth case was a quotidian of
three weeks, attended with a cough of the
same standing, and joined with sea scurvy.
In all of them the bark had been given
at some period or other; and the flowers of
zinc were now tried in all, except the last.
In three out of the five this medicine had
the most visible good effects. In one the
disease was so speedily removed, that there
was only one fit after the first day of taking
this medicine, and the other two had recovered
perfectly after it had been used for seven
days.
In these cases there can be little or no
ambiguity with regard to the real efficacy of
the medicine, as the disease had lasted from
two to six months, and there was no other
circumstance of change in the situation or
treatment of the patients that could account
for their recovery.
Of the two cases in which it failed, one
was the tertian of three months, attended
with the eruption; the other was the relapsed
tertian of three days.
With regard to the dose, I began with
giving it in the quantity of two grains
thrice a day, which, in some, produced the
desired effect, and without the least sensible
operation on the stomach or bowels. If
this dose did not stop the fits after a few
days trial, it was increased to three grains,
which, in some, would produce a little sickness.
I found that four grains ruffled the
stomach a good deal; but if the patient is
gradually habituated to it, even more than
this may be given without inconvenience.
In those cases in which it was successful
it was not found necessary to give more
than two grains at a dose, except in one of
them, in which three were given the day
before the fit ceased. In the two unsuccessful
cases the medicine had a fair trial for a
fortnight; but one of them getting no better,
and the other seeming to get worse, it
was left off.
The cases to which this medicine is
adapted are those that have extremely distinct
remissions, with no symptoms of bile
nor any local affection. When agues come
to be long protracted, they are frequently
what may be called nervous; that is, consisting
of certain morbid motions that seem
to be induced by habit, after the original
cause is removed, and with a tolerable enjoyment
of appetite, sleep, and all the functions
of life, during the intermission.
The two cases in which the zinc failed
recovered by the use of the bark. This
had been unsuccessfully tried before, and its
good effects now might either depend on its
having been left off for some time, whereby
the body recovered its sensibility to its virtues,
or it might be in consequence of administering
it in ardent spirits with a few
grains of capsicum and ginger, additions
which I found to improve its effects in other
cases, and is a mode of giving it well suited
to this climate.
The zinc was not tried in the sixth case,
on account of the local affection and the remission
being short and imperfect.
The white vitriol, being a salt of zinc,
might be supposed to possess the same virtues;
and it would appear to do so from
some facts111 that were reported to me in the
West Indies, and also from some trials made
by me at St. Thomas’s hospital since I came
to England.
Though this is a medicine of very considerable
powers, I do not mean to put it in
competition with the bark, by proposing it
as a substitute for it, or by representing it
as superior to it in all circumstances; but
only to propose it as a valuable subsidiary in
particular cases. The account I have given
is faithfully extracted from a diary of my
practice; and were I to say more in its favour
than the future experience of others
may warrant, I should do more harm than
service to its reputation. Many good medicines
have had their characters hurt by being
over-rated by the first proposers of them,
who are naturally sanguine and partial, without,
perhaps, intending to deceive. But
when others find that their virtues do not
come up to what has been asserted, they are
apt to run into the other extreme, and explode
them altogether; so that what was
given out as good for every thing, is now
found to be good for nothing112.